Radiographic abnormalities of the duodenum in cystic fibrosis

Phelan, Margaret; Fine, David; Zentler-Munro, P L; Hodson, Margaret E.; Batten, John; Kerr, I.H.

doi:10.1016/s0009-9260(83)80168-8

Cited by 20 publications

(7 citation statements)

References 14 publications

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“…This low incidence of peptic ulcer disease is not ascribable to an absence of upper gastrointestinal acid-peptic disease, since severe acid-peptic esophageal injury is common (59,60). Furthermore, CF patients, who are frequently endoscoped for upper gastrointestinal symptoms, have characteristic duodenal mucosal abnormalities (61), and can be infected with Helicobacter pylori (62). These observations further support our "intracellular bicarbonate" hypothesis: diminished apical bicarbonate exit with intact basolateral bicarbonate influx increases the steady state intracellular bicarbonate/pH i in the vulnerable duodenal epithelial cells in these patients, protecting them from injury due to luminal acid.…”

Section: Figuresupporting

confidence: 60%

Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury

Akiba

Furukawa²,

Guth³

et al. 2001

J. Clin. Invest.

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Section: Figuresupporting

confidence: 60%

Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury

Akiba

Furukawa²,

Guth³

et al. 2001

J. Clin. Invest.

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“…Abnormalities of the duodenum are reported in over 80% of CF adults 2,17 . The duodenal cap or second part of the duodenum is usually involved 13,17 .…”

Section: Duodenal Abnormalitiesmentioning

confidence: 99%

“…Abnormalities of the duodenum are reported in over 80% of CF adults 2,17 . The duodenal cap or second part of the duodenum is usually involved 13,17 . The reduction in normal pancreatic enzymes exposes the duodenal mucosa to unbuffered gastric acid, which causes ulceration in some patients.…”

Section: Duodenal Abnormalitiesmentioning

confidence: 99%

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Abdominal manifestations of cystic fibrosis in adults: A review

Constantine

Slavotinek

2004

Australasian Radiology

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Gastrointestinal manifestations of disease are present in most adults with cystic fibrosis. Radiologists are familiar with the classical imaging characteristics of end-stage pulmonary disease and the radiological findings of meconium ileus in neonates. As most patients now live into adulthood, recognition of the imaging appearances of abdominal disease is important to enable prompt diagnosis and treatment. Accordingly, this article presents typical imaging appearances of the adult gastrointestinal manifestations of cystic fibrosis.

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“…Dyspepsia is frequently observed in patients with cystic fibrosis (CF) (22). Radiographic studies of the duodenum in CF patients with abdominal pain have revealed abnormalities such as thickened mucosal folds, effacement of normal folds, and peptic ulcerations in approximately 85% of the investigated patients (35,43). The epigastric pain might be caused by the intensive antibiotic treatment used in these patients or pancreatic insufficiency.…”

mentioning

confidence: 99%

Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori

Johansen

Nørgaard

Andersen

et al. 1995

Clin Diagn Lab Immunol

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Cystic fibrosis (CF) patients suffer from many of the gastrointestinal conditions which occur in non-CF individuals, e.g., dyspepsia and peptic ulceration. These symptoms may be caused by Helicobacter pylori but could also be due to either pancreatic insufficiency or the intensive antibiotic treatment used in CF patients. Since CF patients chronically infected with Pseudomonas aeruginosa produce antibodies against a wide range of antigens, including antigens common to many other bacteria, e.g., GroEL and lipopolysaccharide, we studied, by the Western blot (immunoblot) technique, the specificity of immunoglobulin G antibodies to H. pylori in Danish CF patients chronically infected with P. aeruginosa, CF patients without P. aeruginosa infection but with Haemophilus influenzae infection, patients with dyspeptic ulcers associated with H. pylori, and patients recovering from acute Campylobacter jejuni or Campylobacter coli infection. Sera from CF patients with chronic P. aeruginosa or H. influenzae infection and patients recovering from acute C. jejuni infection cross-reacted with H. pylori antigens. A strong cross-reacting protein antigen at approximately 14 kDa and minor cross-reactive antigens at approximately 27, 30, and 60 kDa (the heat shock protein GroEL is equivalent to the common antigen of P. aeruginosa) could be demonstrated. The results of this study show that high immunoglobulin G antibody titers against H. pylori in CF patients cannot be regarded as indicating present or past H. pylori infection unless their specificity is proven by absorption studies.

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Radiographic abnormalities of the duodenum in cystic fibrosis

Cited by 20 publications

References 14 publications

Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury

Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury

Abdominal manifestations of cystic fibrosis in adults: A review

Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori

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