“…The CPAP studies included trials comparing CPAP versus sub-therapeutic (sham) CPAP [ 4 – 34 ], CPAP versus an oral placebo [ 33 , 35 – 43 ], CPAP versus conservative or no therapy [ 10 , 22 , 44 – 54 ], CPAP versus an oral appliance [ 4 , 5 , 36 , 51 , 55 – 63 ], CPAP versus postural therapy [ 64 – 67 ], and CPAP alone assessing different means to modify adherence (e.g., with vs. without a humidifying element) [ 8 , 21 , 30 , 68 – 79 ]. The surgical trials assessed a variety of single- and multi-stage procedures incorporating uvuloplasty [ 22 , 80 – 117 ], mandibular advancement [ 118 , 119 ], laser treatments [ 120 – 125 ], radiofrequency tissue reduction and other lingual procedures [ 117 , 125 – 134 ], and palate implants [ 135 – 141 ], in addition to five trials specifically evaluating the safety versus risks of OSA surgery, including its safety as an outpatient/same-day procedure [ 142 – 146 ]. The PRISMA charts seen in Figs.…”