Radiofrequency Radiation at 40kHz Induces Hepatic Injury in Long-Evans Cinnamon (LEC) Rats, an Animal Model for Human Wilson Disease

Abstract

ABSTRACT. In the present study, we examined effects of radiofrequency (RF) radiation at 40 kHz on hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model for human Wilson disease, which is a heritable disease of copper metabolism in the liver. The activities of ALT and AST in serum of LEC rats exposed to RF radiation for 2 weeks were approximately 3.8-fold and 2-fold higher than those in serum of sham-exposed rats, respectively. Although there were no significant differences in hepatic copper contents between LEC rats exposed to RF radiation for 2 weeks and sham-exposed rats, copper contents in the kidney and serum of exposed LEC rats were approximately 4.2-fold and 12.9-fold higher than those in sham-exposed rats, respectively. Relative O 2 --scavenging activities in the S-100 fraction of the liver of LEC rats exposed to RF radiation for 2 weeks were 1.6-fold higher than those in sham-exposed rats. No significant differences were observed in activities of AST and ALT in serum and relative O 2 --scavenging activity in the S-100 fraction of the liver of normal control WKAH rats that were sham-exposed and exposed to RF radiation. No significant differences were observed in copper contents in the liver, kidney and serum of WKAH rats that were sham-exposed and exposed to RF radiation for 2 weeks. The results show that RF radiation at 40 kHz induced hepatic injury in LEC rats.

Structural Changes Observed in Mice Liver Due to Chronic Exposure of 1900-2200 MHZ Radiations Emitted From Mobile Phone

“…Mohammed Fathy Assasa [25] observed a significant increase in SGOT and SGPT following exposure of rat to EMF from cellular telephones base stations with frequency of 900 MHz. Exposure of rats to radiofrequency radiation for 2 weeks at 40 KHz increased approximately 3.8-fold and 2-fold higher SGPT and SGOT respectively [26]. Our study observations are consistent with Ma HR et al [24] study.…”

Thermal build-up, decay and retention responses to local therapeutic application of 448 kHz capacitive resistive monopolar radiofrequency: A prospective randomised crossover study in healthy adults

“…Although the research is sparse, EPAs operating at significantly lower RF ranges (< 1 MHz) have also been reported and used in clinical practice to induce mild hyperthermia and other physiological effects [15][16][17][18]. An example for such EPAs currently used in therapy practice is Capacitive Resistive Monopolar Radiofrequency (CRMRF) that operates at a frequency of 448 kHz.…”

Radiofrequency-based treatment in therapy-related clinical practice – a narrative review. Part I: acute conditions

“…The authors of this review identified a limited number of articles pertaining to this area. [46][47][48]50,[64][65][66][67][68][69][70][71][72][73][74][75][76][77] The current literature (published in English) indicates that the RF used in therapy-related clinical practice is predominantly in the SWT band, and largely limited to PSWT as a delivery mode. 3,9,62,[78][79][80] Although several authors have reviewed the therapeutic effects of SWT as they are applied to various specific conditions, 56,62,79,[81][82][83] none covers all the therapy-related clinical literature in this frequency spectrum.…”