Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck

Paola, Marco Di; Gatti, Davide; Viapiana, Ombretta; Cianferotti, Luisella; Cavalli, Loredana; Caffarelli, Carla; Conversano, Francesco; Quarta, E.; Pisani, Paola; Girasole, G.; Giusti, Andrea; Manfredini, M.; Arioli, G.; Matucci‐Cerinic, M.; Bianchi, Gerolamo; Nuti, Ranuccio; Gonnelli, Stefano; Brandi, Maria Luisa; Muratore, Maurizio; Rossini, Maurizio

doi:10.1007/s00198-018-4686-3

Cited by 66 publications

(92 citation statements)

References 36 publications

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“…Therefore, it is currently not recommended to monitor treatment response according to the International Society for Clinical Densitometry (ISCD) 24 , given the lack of large-scale studies outlining monitoring efficacy 29 . Quite recently, another ultrasound approach (Echographic Spectrometry) has been proposed 30 .…”

mentioning

confidence: 99%

Concept of a Radiofrequency Device for Osteopenia/Osteoporosis Screening

Makarov

Noetscher

Arum

et al. 2020

Sci Rep

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Osteoporosis represents a major health problem, resulting in substantial increases in health care costs. There is an unmet need for a cost-effective technique that can measure bone properties without the use of ionizing radiation. The present study reports design, construction, and testing of a safe, and easy to use radiofrequency device to detect osteoporotic bone conditions. The device uses novel on-body antennas contacting the human wrist under an applied, operator-controlled pressure. For the dichotomous diagnostic test, we selected 60 study participants (23–94 years old, 48 female, 12 male) who could be positively differentiated between healthy and osteopenic/osteoporotic states. The band-limited integral of the transmission coefficient averaged for both wrists, multiplied by age, and divided by BMI has been used as an index. For a 100 MHz frequency band centered about 890–920 MHz, the maximum Youden’s J index is 81.5%. Both the sensitivity and specificity simultaneously reach 87% given the calibration device threshold tolerance of ±3%. Our approach correlates well with the available DXA measurements and has the potential for screening patients at risk for fragility fractures, given the ease of implementation and low costs associated with both the technique and the equipment. The inclusion of radiofrequency transmission data does add supplementary useful information to the available clinical risk factors.

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mentioning

confidence: 99%

Concept of a Radiofrequency Device for Osteopenia/Osteoporosis Screening

Makarov

Noetscher

Arum

et al. 2020

Sci Rep

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“…The technique is promising because REMS-measured BMD values have shown good agreement with the corresponding DXA-measured values. 97 With regard to sarcopenia, to date most studies have focused on US evaluation of muscle size, echo intensity, and architecture. 98 However, no conclusive recommendation is currently available about its use in clinical practice, and US is then poorly utilized.…”

Section: Quantitative Ultrasound In Osteosarcopeniamentioning

confidence: 99%

Quantitative Musculoskeletal Ultrasound

Gitto

Messina

Vitale

et al. 2020

Semin Musculoskelet Radiol

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Ultrasound (US) imaging plays a crucial role in the assessment of musculoskeletal (MSK) disorders. Several quantitative tools are offered by US systems and add information to conventional US imaging. This article reviews the quantitative US imaging tools currently available in MSK radiology, specifically focusing on the evaluation of elasticity with shear-wave elastography, perfusion with contrast-enhanced US and noncontrast superb microvascular imaging, and bone and muscle mass with quantitative US methods. Some of them are well established and already of clinical value, such as elasticity and contrast-enhanced perfusion assessment in muscles and tendons. MSK radiologists should be aware of the potential of quantitative US tools and take advantage of their use in everyday practice, both for clinical and research purposes.

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“…In 2018, results of the first multi-centre study, evaluating the diagnostic usefulness of REMS in comparison with DXA, were published [23]. It included 1914 post-menopausal women aged 50-71, referred for a DXA scan of the femoral neck and/or the lumbar spine.…”

Section: Clinical Significance Of Rems Densitometrymentioning

confidence: 99%

“…According to the available literature, these values in DXA method are higher and equal to 1.47% and 1.07-1.34%, respectively. This suggests lower repeatability of DXA measurements and requires further verification in well-designed comparative studies [23].…”

Section: Clinical Significance Of Rems Densitometrymentioning

confidence: 99%

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in the diagnosis of osteoporosis

Iwaszkiewicz¹,

Leszczyński²

2019

Forum Reumatologiczne

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The paper summarises the present knowledge of the new bone densitometry method called radiofrequency echographic multi-spectrometry (REMS). This ultrasound-based approach enables the evaluation of bone mineral density (BMD) in the hip and the lumbar spine. During REMS densitometry, a fully automatic algorithm performs a series of spectral and statistical analyses involving both echographic images and corresponding "raw" (unfiltered) radiofrequency signals. This provides the identification of the region of interest (ROI) and the calculation of standard densitometric parameters: BMD, T-score and Z-score. Nondiagnostic scans and artifacts are automatically excluded by the algorithm, reducing the risk of false results. A recently published multi-center study has demonstrated high diagnostic sensitivity, specificity and accuracy of this innovative method in the diagnosis of osteoporosis. To the authors' best knowledge, this is the first Polish paper on REMS densitometry.

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Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck

Cited by 66 publications

References 36 publications

Concept of a Radiofrequency Device for Osteopenia/Osteoporosis Screening

Concept of a Radiofrequency Device for Osteopenia/Osteoporosis Screening

Quantitative Musculoskeletal Ultrasound

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in the diagnosis of osteoporosis

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