Radiofrequency ablation

Tanabe, Kenneth K.; Curley, Steven A.; Dodd, Gerald D.; Siperstein, Allan; Goldberg, S. Nahum

doi:10.1002/cncr.11919

Cited by 69 publications

(10 citation statements)

References 55 publications

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“…The measurement results suggest that heating induced by nanosecond electric pulses is negligible and is not sufficient to produce permeabilization in cell membranes or to induce hyperthermal effects [18,19]. It can be expected that joule heating produced by each 15 ns pulse is near the surfaces of stainless steel needles and can be completely or partly conducted away with heat diffusion before the 2 nd pulse arrives (after 20 ms).…”

Section: Resultsmentioning

confidence: 99%

Two-dimensional nanosecond electric field mapping based on cell electropermeabilization

et al. 2009

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Nanosecond, megavolt-per-meter electric pulses cause permeabilization of cells to small molecules, programmed cell death (apoptosis) in tumor cells, and are under evaluation as a treatment for skin cancer. We use nanoelectroporation and fluorescence imaging to construct two-dimensional maps of the electric field associated with delivery of 15 ns, 10 kV pulses to monolayers of the human prostate cancer cell line PC3 from three different electrode configurations: single-needle, five-needle, and flat-cut coaxial cable. Influx of the normally impermeant fluorescent dye YO-PRO-1 serves as a sensitive indicator of membrane permeabilization. The level of fluorescence emission after pulse exposure is proportional to the applied electric field strength. Spatial electric field distributions were compared in a plane normal to the center axis and 15-20 μm from the tip of the center electrode. Measurement results agree well with models for the three electrode arrangements evaluated in this study. This live-cell method for measuring a nanosecond pulsed electric field distribution provides an operationally meaningful calibration of electrode designs for biological applications and permits visualization of the relative sensitivities of different cell types to nanoelectropulse stimulation. PACS Codes: 87.85.M-

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Section: Resultsmentioning

confidence: 99%

Two-dimensional nanosecond electric field mapping based on cell electropermeabilization

et al. 2009

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“…The incidence of complications depends on many factors and has been described to be related to the type of approach, tumor size and location and the physician's experience [6,7,12,13,14]. Morbidity rates vary in the literature between as low as 5 and up to 30% in some reports [6,9,15].…”

Section: Discussionmentioning

confidence: 99%

Complications after Radiofrequency Ablation of 233 Hepatic Tumors

2015

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Objective: The only curative treatment for primary and secondary hepatic malignancies is surgery and liver transplantation. Thus, the majority of the patients are not candidates for resection, and there is a lack of organs. For these reasons, alternative treatment modalities such as radiofrequency ablation (RFA) are employed. The objective of this paper is to evaluate the incidence and types of complications related to open and percutaneous RFA. Method: This is a retrospective study of patients with hepatic malignancies treated by RFA. Tumor size, location, numbers of nodules, approach, histology and associated procedures were analyzed and correlated to complications. Results: A total of 151 patients with primary and secondary hepatic malignancies were included: 58 with hepatocellular carcinoma (HCC), 68 with metastases from colorectal cancer and 25 with other types of tumors. Complications occurred in 24.5% of the patients, mostly (58.9%) in those with HCC. Ascites was the most common complication, followed by wound infection. The only two significant factors associated with complications were the presence of HCC (p = 0.0087) and two or more lesions (p = 0.0323). The mortality rate was 0.69%. Conclusion: RFA is a safe technique, but complications may occur and are multifactorial. Appropriate patient selection, early complication recognition and adequate treatment are essential.

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“…It is hoped that the current analysis and proposal strengthens the opinion of the proponents [19, 25, 30, 31, 36, 37, 42, 46, 48, 50, 53, 57, 61, 67, 86, 98, 125, 181,183,184,185,186,187, 192, 193] of such a study and contributes to convince its opponents [18, 58, 59, 62,188,189,190, 194]. We hope that, in the era of evidence-based medicine, the surgical community will support a renewed effort to run such a trial (for more information, please contact: t.ruers@nki.nl or stefaan.mulier@skynet.be).…”

Section: Discussionmentioning

confidence: 99%

“…Enthusiasm about these at first sight promising results in the ‘palliative’ (see further) setting has led an increasing number of interventional radiologists to suggest [31] or to apply and defend [23, 25,32,33,34,35,36,37] (percutaneous) radiofrequency ablation for the treatment of resectable CRLM too, even though there is no evidence yet from randomized trials to support this. Even some surgeons are suggesting that RFA may replace resection, especially in certain circumstances such as new hepatic metastases after a first liver resection [38,39,40,41,42,43,44], limited central disease that technically would require a hemihepatectomy [42, 45, 46], small metastases [42, 45,47,48,49] and solitary metastases [50].…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency Ablation versus Resection for Resectable Colorectal Liver Metastases: Time for a Randomized Trial?

et al. 2008

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Background: A recent proposal of a randomized trial comparing resection and radiofrequency ablation (RFA) in a selected subgroup of patients with small resectable colorectal liver metastases (CRLM) has initiated a debate on this issue. Meanwhile, new data have been published. The aim of the study was to update and critically review the oncological evidence in favor of and against the use of RFA for resectable CRLM in general and in favor of and against conducting a randomized trial in a selected subgroup of patients. Methods: An exhaustive review was carried out of papers and abstracts on RFA of colorectal metastases published before July 15, 2008. Results: Local recurrence rate after resection of CRLM is 1.2–10.4%. Local recurrence rate after RFA of CRLM is between 1.7 and 66.7%. For tumors <3 cm, local control after open RFA is equivalent to resection. Local recurrence rates, however, are higher for larger tumors and for the percutaneous and laparoscopic route. Accumulating evidence suggests that RFA and resection induce profoundly different biological effects, which may influence survival. Conclusions: Local recurrence rate after open RFA for CRLM <3 cm seems to be equivalent to resection. A randomized trial under strict conditions would be justified in this subgroup of patients. A randomized trial is currently not justified for larger tumors or for percutaneous or laparoscopic RFA, since local recurrence rates in these groups are too high to be acceptable for resectable tumors.

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Radiofrequency ablation

Cited by 69 publications

References 55 publications

Two-dimensional nanosecond electric field mapping based on cell electropermeabilization

Two-dimensional nanosecond electric field mapping based on cell electropermeabilization

Complications after Radiofrequency Ablation of 233 Hepatic Tumors

Radiofrequency Ablation versus Resection for Resectable Colorectal Liver Metastases: Time for a Randomized Trial?

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