Radiochemotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer

Schäfer, C.; Dietl, B.; Kölbl, Oliver

doi:10.1038/sj.bjc.6603076

Cited by 3 publications

(2 citation statements)

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“… 2,76,77 W–F ratio showed 100% sensitivity and negative-predictive value in accurately predicting non-responders. 77 The W–F ratio showed limitation in the characterization of diffuse breast cancers and lobular carcinoma. 77 …”

Section: Identification Of Biomarkers and Their Diagnostic Significanmentioning

confidence: 99%

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In vivo MR spectroscopy for breast cancer diagnosis

Sharma

Jagannathan

2019

BJR|Open

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Breast cancer is a significant health concern in females, worldwide. In vivo proton (1H) MR spectroscopy (MRS) has evolved as a non-invasive tool for diagnosis and for biochemical characterization of breast cancer. Water-to-fat ratio, fat and water fractions and choline containing compounds (tCho) have been identified as diagnostic biomarkers of malignancy. Detection of tCho in normal breast tissue of volunteers and in lactating females limits the use of tCho as a diagnostic marker. Technological developments like high-field scanners, multi channel coils, pulse sequences with water and fat suppression facilitated easy detection of tCho. Also, quantification of tCho and its cut-off for objective assessment of malignancy have been reported. Meta-analysis of in vivo 1H MRS studies have documented the pooled sensitivities and the specificities in the range of 71–74% and 78–88%, respectively. Inclusion of MRS has been shown to enhance the diagnostic specificity of MRI, however, detection of tCho in small sized lesions (≤1 cm) is challenging even at high magnetic fields. Potential of MRS in monitoring the effect of chemotherapy in breast cancer has also been reported. This review briefly presents the potential clinical role of in vivo 1H MRS in the diagnosis of breast cancer, its current status and future developments.

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Section: Identification Of Biomarkers and Their Diagnostic Significanmentioning

confidence: 99%

“… 77 The W–F ratio showed limitation in the characterization of diffuse breast cancers and lobular carcinoma. 77 …”

Section: Identification Of Biomarkers and Their Diagnostic Significanmentioning

confidence: 99%