Radiochemistry of macroaggregated albumin and newer lung scanning agents

Taplin, George V.; MacDonald, Norman S.

doi:10.1016/s0001-2998(71)81013-9

Cited by 41 publications

(11 citation statements)

References 27 publications

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“…The frequency of IP assignments varies greatly (up to 51% [2], generally 10-30% [29,75,76,78,79,84]) according to patient pre-selection (e.g., reason for investigation, experience of the physician); the use of the modifi ed PIOPED criteria reduced the frequency of such assignments [16,17,21,65,66,77].…”

Section: Intermediate Probability (Indeterminate)mentioning

confidence: 99%

“…No hemodynamic effects were induced by 35-μm particles up to 40 mg/kg body weight, whereas particles sized 80 μm and above showed such effects (raised pulmonary blood pressure, lower pressure in the femoral artery) at 40 mg/kg and even lower dosages for larger particles [2]. Thus, a lower toxic limit of 20 mg/kg may be assumed [2,139].…”

Section: Safety Aspects Of Tc-99m-maa Lung Perfusion Scintigraphymentioning

confidence: 99%

“…The ideal particle size for good image quality has been stated to be 20-50 μm [2] or 15-40 μm [13]. Today, a range of 25-60 μm is preferred; smaller particles are degraded very rapidly, whereas those in excess of ∼60 μm can block the capillary tree at higher levels and thus potentially cause hemodynamic disturbance.…”

mentioning

confidence: 99%

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Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

et al. 2009

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Lung perfusion scintigraphy (LPS) with technetium-99m-labeled macro-aggregates of albumin (Tc-99m-MAA) is well established in the diagnostic of pulmonary embolism (PE). In the last decade, it was shown that single-photon emission computer tomography (SPECT) acquisition of LPS overcame static scintigraphy. Furthermore, there are rare indications for LPS, such as preoperative quantification of regional lung function prior to lung resection or transplantation, optimization of lung cancer radiation therapy, quantification of right-left shunt, planning of intra-arterial chemotherapy, and several rare indications in pediatrics. Moreover, LPS with Tc-99m-MAA is a safe method with low radiation exposure. PE can also be diagnosed by spiral computer tomography (CT), ultrasound, magnetic resonance angiography, or pulmonary angiography (PA, former gold standard). The present review considers all these methods, especially spiral CT, and compares them with LPS with respect to sensitivity and specificity and gives an overview of established and newer publications. It shows that LPS with Tc-99m-MAA represents a diagnostic method of continuing value for PE. In comparison with spiral CT and/or PA, LPS is not to be defeated as mentioned also by the most actual Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) II reports. This applies in particular to chronic or recurring embolisms, whereas currently spiral CT may be of greater value for major or life-threatening embolisms. At present, LPS cannot be replaced by other methods in some applications, such as pediatrics or in the quantification of regional pulmonary function in a preoperative context or prior to radiation therapy. LPS still has a place in the diagnostics of PE and is irreplaceable in several rare indications as described earlier.

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Section: Intermediate Probability (Indeterminate)mentioning

confidence: 99%

Section: Safety Aspects Of Tc-99m-maa Lung Perfusion Scintigraphymentioning

confidence: 99%

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Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

et al. 2009

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“…Large particles are required to prevent rapid uptake. Macroaggregated albumin is well suited for this purpose because it can be formed into any desired size from 10 nm to 100 pm or larger by variations in heat treatment and pH adjustment [10]. TechneScan MAA (Mallinckrodt) contains aggregated albumin in which at least 90% of the particles are 10-90 um in size, with the typical distribution consisting of approximately 90% within the 10-40 pm range.…”

Section: Commentsmentioning

confidence: 99%

“…This particle size is larger than the diaphragmatic mesothelial pore diameter and may be resistant to uptake. Adjustment of pH to 5.5 is important in the formation of the macroaggregates, and maintenance of this pH helps to delay particle breakdown [10]. Standard peritoneal dialysis solution (Travenol 1.5%) has a pH of 5.5 and can be used to fill the perito neal space without danger of excess fluid load for the patient, while still providing an optimal pH.…”

Section: Commentsmentioning

confidence: 99%

Technetium-99m-Labelled Macroaggregated Albumin in Demonstration of Trans-Diaphragmatic Leakage of Dialysate in Peritoneal Dialysis

Spadaro¹,

Thakur²,

Nolph³

1982

Am J Nephrol

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A patient developed a right pleural effusion soon after starting a program of continuous ambulatory peritoneal dialysis. The etiology of the effusion was unclear. ^99mTc-labelled macroaggregated albumin was administered intrapentoneally, followed by 2 liters of dialysate. Trans-diaphragmatic leakage was clearly demonstrated, and confirmed by high count rates of pleural fluid with negligible blood count. This method can safely be used to demonstrate trans-diaphragmatic fluid leakage in peritoneal dialysis patients.

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A new thrombectomy catheter device (AngioJet) for the disruption of thrombi: An in vitro study

Stähr

Rupprecht

Voigtländer

et al. 1999

Cathet Cardio Intervent

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Radiochemistry of macroaggregated albumin and newer lung scanning agents

Cited by 41 publications

References 27 publications

Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

Ventilation/perfusion lung scintigraphy: what is still needed? A review considering technetium-99m-labeled macro-aggregates of albumin

Technetium-99m-Labelled Macroaggregated Albumin in Demonstration of Trans-Diaphragmatic Leakage of Dialysate in Peritoneal Dialysis

A new thrombectomy catheter device (AngioJet) for the disruption of thrombi: An in vitro study

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