A new thrombectomy catheter device (AngioJet) for the disruption of thrombi: An in vitro study

Stähr, Peter; Rupprecht, Hans‐Jürgen; Voigtländer, Thomas; Post, Felix; Otto, Mike; Erbel, Raimund; Meyer, Jürgen

doi:10.1002/(sici)1522-726x(199907)47:3<381::aid-ccd29>3.0.co;2-#

Cited by 17 publications

(14 citation statements)

References 54 publications

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“…Our tests showed that for a given catheter, the vacuum pressures required to aspirate a 6‐ or 12‐hr thrombus were similar, the difference lying in the fact that 12‐hr thrombi are partially organized, as necroscopic studies have shown [9]. As the intervention takes place between 6 and 12 hr after MI onset, our findings are clinically valid.…”

Section: Discussionsupporting

confidence: 64%

“…However, the chosen diameter was smaller than that of the epicardic arteries, which are generally treated by PCI (even more so for TA) [7, 8]. Moreover, the biomechanical properties of gelatin do not correspond to those of thrombi, which are the result of a dynamic process [9]. The impact of these choices was to limit the clinical relevance of the results.…”

Section: Discussionmentioning

confidence: 99%

“…The impact of these choices was to limit the clinical relevance of the results. By using 3 mm diameter thrombi created in vitro, we created conditions that are closer to those found in clinical practice [9].…”

Section: Discussionmentioning

confidence: 99%

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Large tube section is the key to successful coronary thrombus aspiration: Findings of a standardized bench test

Rioufol¹,

Collin²,

Vincent-Martin³

et al. 2005

Cathet Cardio Intervent

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Thrombus removal by aspiration is one of the adjunctive techniques used to avoid embolization during PCI for acute myocardial infarction. Numerous devices are now available, but little is known about the mechanical rationale used in comparing them. The aim of the present study was to determine parameters to obtain optimal thrombus aspiration (TA). Heparin- and antiplatelet-free blood samples were aspirated into 3 mm diameter standardized glass tubes to create a 30 mm long thrombus. Thrombus formation took place at room temperature over a period of 6 or 12 hr. Various catheters were tested using a variable vacuum device: three with right-angle distal tip (0.038'', 0.067'', and 0.070'') and one with a beveled distal (length of the beveled, 0.054''; inner diameter catheter, 0.040''). The single endpoint was complete thrombus aspiration. A total of 103 TAs were presented for the four catheters. For 6- or 12-hr-old thrombus for a given catheter, there was no significant difference in vacuum pressure required to succeed TA (P = 0.47). For 6- or 12-hr-old thrombus, the larger the contact area is, the lower the pressure needed to aspirate the thrombus. Moreover, a beveled distal tip length (0.054'') does not make it possible to succeed TA at a lower pressure. The main factor for successful TA for thrombi > or = 6 hr is inner diameter and not immediate thrombus contact area.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Large tube section is the key to successful coronary thrombus aspiration: Findings of a standardized bench test

Rioufol¹,

Collin²,

Vincent-Martin³

et al. 2005

Cathet Cardio Intervent

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“…The Angiojet catheters come in several diff erent diameters and lengths which suit for blood vessels of a variety of diameters. This system has the ability to clear a vessel much larger than the catheter diameter compared to other mechanical devices [7]. The device may be used alone, or following pharmacologic thrombolysis or standard catheter aspiration thrombectomy.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous rheolytic mechanical thrombectomy in thrombosed direct intrahepatic portosystemic shunt: Report of two cases

Tsetis

Kehagias

Samonakis

et al. 2015

IMAS

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“…This process leads to the formation of a complex structure with different mechanical properties than fresh thrombus (7, 26). Accordingly, mechanical thrombectomy devices might be expected to perform differently in organized compared with fresh thrombus (27). Thus, the proposed model aimed to create a more “real life” thromboembolism.…”

Section: Discussionmentioning

confidence: 99%

Experimental Model of Large Pulmonary Embolism Employing Controlled Release of Subacute Caval Thrombus in Swine

Barbash¹,

Schenke²,

Halabi³

et al. 2011

Journal of Vascular and Interventional Radiology

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Purpose We aimed to develop a catheter based model of large pulmonary embolism in swine based on in situ venous thrombus formation. Materials and Methods Ten Yorkshire swine underwent transjugular implantation of a retrievable inferior vena cava (IVC) filter. A thrombin and collagen mixture was injected into a confined space created by two inflated balloons proximal and distal to the IVC filter. Animals were survived for 7±3 days to allow the thrombus to organize in situ. The caval thrombus was released upon transcatheter retrieval of the IVC filter and embolized into the main and branch pulmonary arteries. The severity of pulmonary embolism was scored by digital subtraction angiography (Miller index). At necropsy thrombi were recovered and analyzed by histopathology. Results Large pulmonary embolism was induced in all animals (average Miller index score of 15±5). Two animals developed saddle embolus with bilateral pulmonary artery occlusion and five developed proximal occlusion of either the left or right pulmonary arteries. Nevertheless no animal exhibited significant hemodynamic compromise. Large tubular thrombi were explanted in the size range of 5–10 cm long and .5–1 cm wide. Histology indicated an organized thrombus with infiltration of white blood cells and fibrin deposition. Conclusions Large caval thrombi can be formed in vivo and released at a predetermined time to induce large pulmonary embolism in a large animal model. This may help developing and testing new therapeutic approaches for pulmonary embolism.

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A new thrombectomy catheter device (AngioJet) for the disruption of thrombi: An in vitro study

Cited by 17 publications

References 54 publications

Large tube section is the key to successful coronary thrombus aspiration: Findings of a standardized bench test

Large tube section is the key to successful coronary thrombus aspiration: Findings of a standardized bench test

Percutaneous rheolytic mechanical thrombectomy in thrombosed direct intrahepatic portosystemic shunt: Report of two cases

Experimental Model of Large Pulmonary Embolism Employing Controlled Release of Subacute Caval Thrombus in Swine

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