Radiochemical Separations by Thermochromatography

Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons

“…The new production scheme of medical radioisotopes, such as 99 Mo, 64 Cu and 67 Cu, using accelerator neutrons is introduced in chapter 3. The development of separation methods of 99m Tc from 99 Mo,and 64 Cu and 67 Cu from Zn samples are given in chapter 4. The deuteron accelerator and the accelerator neutron source are described in chapter 5.…”

“…We have proposed new routes to produce carrier-free medical radioisotopes of 90 Y, 43) 64 Cu, and 67 Cu 44), 45) using accelerator neutrons provided by the nat C(d,n) reaction. Successful PET with the use of 18 F for assessments of tumor characterization has triggered a search for a longer half-life PET RI to diagnose the dynamics of a medicine in a living body that has a slow reaction time.…”

“…Successful PET with the use of 18 F for assessments of tumor characterization has triggered a search for a longer half-life PET RI to diagnose the dynamics of a medicine in a living body that has a slow reaction time. 64 Cu with a half-life of T 1/2 F 12.7 h, longer than that of 18 F (T 1/2 F 1.8 h), is considered to be a promising RI suitable for labeling many radiopharmaceuticals for PET imaging, 2) Fig. 11.…”

“…-rays in H 2 O is as long as 12 mm. 67 Cu (T 1/2 F 62 h), a pair radioisotope of 64 Cu, is considered to be a promising radionuclide for treating small distant metastases of up to 4 mm in size in radioimmunotherapy. 6) 67 Cu has unique nuclear properties and chemical behavior for use in RIT.…”

“…We have proposed a new production scheme of 99 Mo as well as therapeutic radioisotopes, such as 64 Cu and 67 Cu, using accelerator neutrons provided by the nat C(d,n) reaction. Based on this scheme we have obtained high-quality 99m Tc, 64 Cu, and 67 Cu suitable for clinical use by developing both production and separation methods of the radioisotopes. We proposed a new facility to constantly and reliably produce a wide variety of high-quality, carrier-free radioisotopes, including 99 Mo, with accelerator neutrons.…”