Radiobiology for eye plaque brachytherapy and evaluation of implant duration and radionuclide choice using an objective function

Gagne, Nolan L.; Leonard, Kara L.; Rivard, Mark J.

doi:10.1118/1.4718683

Cited by 32 publications

(40 citation statements)

References 52 publications

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“…Following the methodology proposed above, the MCNP5 Monte Carlo (MC) radiation transport code [21] was used to simulate dose distributions for 14, 16 and 18 mm diameter COMS eye plaques with material compositions and reference geometry identical to those employed previously [5, 9]. These plaque sizes were selected to investigate a range of customization capabilities afforded by their distinct numbers of rings (three in the 16 mm plaque, four in the 14 mm plaque and five in the 18 mm plaque).…”

Section: Methodsmentioning

confidence: 99%

“…Source design specifications, absorbed dose determination methods and tally geometry were identical to those developed in Gagne et al . [5]. For the three radionuclides, each constituent ring of the three fully-loaded COMS plaques was activated to determine its contribution to the total dose distribution while accounting for the heterogeneous dosimetric influences of inter-seed attenuation and scatter.…”

Section: Methodsmentioning

confidence: 99%

“…Investigations into the dosimetric and radiobiological effects of plaque size selection, radionuclide type, prescription dose and plaque positioning for eye plaque brachytherapy have been performed [1–5]. Recommendations exist regarding pre-operative quality assurance (QA) procedures such as source strength verification using a well chamber with a NIST-traceable calibration [6, 7].…”

Section: Purposementioning

confidence: 99%

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Keeping an eye on the ring: COMS plaque loading optimization for improved dose conformity and homogeneity

Gagne¹,

Cutright²,

Rivard³

2012

jcb

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PurposeTo improve tumor dose conformity and homogeneity for COMS plaque brachytherapy by investigating the dosimetric effects of varying component source ring radionuclides and source strengths.Material and methodsThe MCNP5 Monte Carlo (MC) radiation transport code was used to simulate plaque heterogeneity-corrected dose distributions for individually-activated source rings of 14, 16 and 18 mm diameter COMS plaques, populated with 103Pd, 125I and 131Cs sources. Ellipsoidal tumors were contoured for each plaque size and MATLAB programming was developed to generate tumor dose distributions for all possible ring weighting and radionuclide permutations for a given plaque size and source strength resolution, assuming a 75 Gy apical prescription dose. These dose distributions were analyzed for conformity and homogeneity and compared to reference dose distributions from uniformly-loaded 125I plaques. The most conformal and homogeneous dose distributions were reproduced within a reference eye environment to assess organ-at-risk (OAR) doses in the Pinnacle3 treatment planning system (TPS). The gamma-index analysis method was used to quantitatively compare MC and TPS-generated dose distributions.ResultsConcentrating > 97% of the total source strength in a single or pair of central 103Pd seeds produced the most conformal dose distributions, with tumor basal doses a factor of 2-3 higher and OAR doses a factor of 2-3 lower than those of corresponding uniformly-loaded 125I plaques. Concentrating 82-86% of the total source strength in peripherally-loaded 131Cs seeds produced the most homogeneous dose distributions, with tumor basal doses 17-25% lower and OAR doses typically 20% higher than those of corresponding uniformly-loaded 125I plaques. Gamma-index analysis found > 99% agreement between MC and TPS dose distributions.ConclusionsA method was developed to select intra-plaque ring radionuclide compositions and source strengths to deliver more conformal and homogeneous tumor dose distributions than uniformly-loaded 125I plaques. This method may support coordinated investigations of an appropriate clinical target for eye plaque brachytherapy.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Purposementioning

confidence: 99%

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Keeping an eye on the ring: COMS plaque loading optimization for improved dose conformity and homogeneity

Gagne¹,

Cutright²,

Rivard³

2012

jcb

Self Cite

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“…The typical duration of an implant in situ varies between 1 and 7 days [34]. At the end of the calculated treatment time, the plaque is removed with a new surgical procedure: 106 Ru/Rh plaques’ integrity and 125 I seeds number and status are checked.…”

Section: Step 5 Treatment Period and Plaque Removalmentioning

confidence: 99%

INTERACTS (INTErventional Radiotherapy ACtive Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) procedures

Tagliaferri¹,

Pagliara²,

Boldrini³

et al. 2017

jcb

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Eye plaque brachytherapy represents a safe and effective therapeutic approach for choroidal melanoma, combining clinical outcomes with an eye and visual preservation.As it represents a complex procedure, a specific quality assurance program is strongly suggested to improve patients and operators safety, and to reduce possible complications linked to surgical procedure and radiation exposure.The aim of this paper is to describe the INTERACTS (Interventional Radiotherapy Active Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) used in our institution.

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“…Furthermore, the approach that we used to determine the set of the optimization parameters is conceptually the same as that used by Gagne et al 37 These parameters represent the current clinical practice, which may be adequate but not optimal and consequently, the parameters that we have used to define the reference gEUD may not be optimal either. However, this is not critical because we use those parameters to define a clinically acceptable reference point.…”

Section: Discussionmentioning

confidence: 99%

A gEUD‐based inverse planning technique for HDR prostate brachytherapy: Feasibility study

Giantsoudi¹,

Baltas

Karabis

et al. 2013

Medical Physics

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Following the promising results of gEUD-based optimization in intensity modulated radiation therapy treatment optimization, as reported in the literature, the implementation of a similar model in HDR brachytherapy treatment plan optimization is suggested by this study. The potential of improved sparing of organs at risk was shown for various gEUD-based optimization parameter protocols, which indicates the ability of this method to adapt to the user's preferences.

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Radiobiology for eye plaque brachytherapy and evaluation of implant duration and radionuclide choice using an objective function

Cited by 32 publications

References 52 publications

Keeping an eye on the ring: COMS plaque loading optimization for improved dose conformity and homogeneity

Keeping an eye on the ring: COMS plaque loading optimization for improved dose conformity and homogeneity

INTERACTS (INTErventional Radiotherapy ACtive Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) procedures

A gEUD‐based inverse planning technique for HDR prostate brachytherapy: Feasibility study

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