INTERACTS (INTErventional Radiotherapy ACtive Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) procedures

Tagliaferri, Luca; Pagliara, Monica Maria; Boldrini, Luca; Caputo, Carmela Grazia; Azario, L.; Campitelli, M.; Gambacorta, Maria Antonietta; Smaniotto, Daniela; Frascino, V.; Deodato, Francesco; Morganti, Alessio Giuseppe; Kovács, György; Valentini, Vincenzo; Blasi, Maria Antonietta

doi:10.5114/jcb.2017.68761

Cited by 33 publications

(24 citation statements)

References 31 publications

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“…[45] Since reports about patient cohorts treated by multidisciplinary IRT are rare, the creation of international large databases and their analysis could help to find high level evidences in the future. [46][47][48] Moreover, we need educational centers focusing to world-class medicine by multidisciplinary decision-making and multidisciplinary treatment performance. [49] The future belongs to multidisciplinary type of treatmentsas documented with the following case: The liver metastases of a colon cancer were cured in the right lobe with the applied TACE (trans-arterial chemo-embolization); however, there was a residual due to the vascular supply from the infiltrated diaphragm.…”

Section: Discussionmentioning

confidence: 99%

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Kovács¹

2019

TJ Oncol

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The delivery of a very high dose by radiotherapy to a dedicated target with minimal surrounding normal tissue dose is a challenging situation. From a radiotherapy point of view, in several anatomic situations, the most optimal method is the use of interventional radiotherapy (brachytherapy; IRT) alone or in combination with other established interventional tumor cell eliminating methods. METHODS First, Interventional Radiotherapy, Interventional Radiology, Interventional Endoscopy and Interventional Chemotherapy have the same aim of eliminating tumor tissue. Second, target definition and some IRT application techniques need multidisciplinary teamwork. RESULTS Multidisciplinary teams have the best potential to offer the best possible cure in localized solid tumors or in selected oligometastatic disease. Examples for this kind of service are given for H&N-, anal-, vaginal-, breast-, prostate cancers as well as in oligometastatic disease. The combined use of interventional tumor ablation techniques is demonstrated. CONCLUSION Interventional Oncology has the potential to improve the treatment results in localized solid cancers or in selected oligometastatic disease, and large workload Interventional Oncology Centers could have an important role in the patient service, in the education as well as in the clinical research.

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Section: Discussionmentioning

confidence: 99%

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Kovács¹

2019

TJ Oncol

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“…Personalized assessments of the risk benefits are essential when considering older patients for adjuvant treatment after breast-conserving surgery. e use of large databases and nomogram could help for improved analysis of the outcomes in these populations [65][66][67][68][69].…”

Section: Discussionmentioning

confidence: 99%

Could a Personalized Strategy Using Accelerated Partial Breast Irradiation be an Advantage for Elderly Patients? A Systematic Review of the Literature and Multidisciplinary Opinion

Tagliaferri

Lancellotta

Colloca

et al. 2020

Journal of Oncology

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Introduction. Elderly patients are underrepresented from a majority of clinical trials and the choice of the best treatment becomes a challenge. The optimal treatment should be personalized and based on a multidisciplinary approach that includes radiation oncologists, surgeons, geriatricians, medical oncologists, social workers, and support services. The global evaluation of the patients and the creation of nomograms may facilitate the definition of long-term treatment benefits minimizing the use of unnecessary therapy. Material and Method. A systematic research using PubMed, Scopus, and Cochrane library was performed to identify full articles analyzing the efficacy of APBI in elderly patients with breast cancer. ClinicalTrials.gov was searched for ongoing or recently completed trials, and PROSPERO was searched for ongoing or recently completed systematic reviews. Results. Seven papers fulfilled the eligibility criteria. The number of evaluated patients was 405 and the median age was 77.7 years. The disease-free survival (DFS) range was 96.1%–100%, the grade 3-4 toxicity range was 0%–6.6%, the cancer-specific survival (CSS) range was 97.9%–100%, and the overall survival (OS) range was 87%–100%. All studies reported excellent/good cosmetic results in a range of 74% to 99%. Conclusion. Accelerated partial breast irradiation (APBI) results in a safe and effective substitute for the adjuvant external beam radiotherapy in selected elderly early-stage breast cancer patients. Based on the relatively low toxicity, APBI should be advised in selected patients with life expectancies larger than 5–10 years.

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“…Confirmation of intraoperative plaque placement were performed by experienced diagnostic ophthalmic echographers to ensure that the plaque was centered on the tumor base and all tumor margins were covered by the plaque. The procedure was performed following the INTERACTS protocol for quality assurance (16).…”

Section: Methodsmentioning

confidence: 99%

AVATAR: Analysis for Visual Acuity Prediction After Eye Interventional Radiotherapy

Pagliara

Tagliaferri

Lenkowicz

et al. 2019

In Vivo

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Aim: The aim of this study was to detect clinical factors predictive of loss of visual acuity after treatment in order to develop a predictive model to help identify patients at risk of visual loss. Patients and Methods: This was a retrospective review of patients who underwent interventional radiotherapy (brachytherapy) with 106 Ru plaque for primary uveal melanoma. A predictive nomogram for visual acuity loss at 3 years from treatment was developed. Results: A total of 152 patients were selected for the study. The actuarial probability of conservation of 20/40 vision or better was 0.74 at 1 year, 0.59 at 3 years, and 0.54 at 5 years after treatment. Factors positively correlated with loss of visual acuity included: age at start of treatment (p=0.004) and longitudinal basal diameter (p=0.057), while distance of the posterior margin of the tumor from the foveola was inversely correlated (p=0.0007). Conclusion: We identified risk factors affecting visual function and developed a predictive model and decision support tool (AVATAR nomogram).

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INTERACTS (INTErventional Radiotherapy ACtive Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) procedures

Cited by 33 publications

References 31 publications

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Could a Personalized Strategy Using Accelerated Partial Breast Irradiation be an Advantage for Elderly Patients? A Systematic Review of the Literature and Multidisciplinary Opinion

AVATAR: Analysis for Visual Acuity Prediction After Eye Interventional Radiotherapy

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