Radiobiological characterization of the inactivating events produced in mammalian cells by helium and heavy ions

Chapman, J. D.; Blakely, Eleanor A.; Smith, Kendric C.; Urtasun, Raul C.

doi:10.1016/0360-3016(77)90234-6

Cited by 89 publications

(69 citation statements)

References 10 publications

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“…The decrease in RBE at the distal peak is due to saturation effects at high LET. This observation was also made more or less simultaneously by Hall et al (1977), Chapman et al (1977), andTobias et al (1977). The hypoxic survival curves at the entrance, peak centre, and distal peak look remarkably similar.…”

Section: Resultssupporting

confidence: 68%

A heavy particle comparative study. Part III: OER and RBE

Raju¹,

Amols²,

Bain³

et al. 1978

BJR

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The results of a comparative study of heavy particles of interest in radiotherapy are reported in four parts. In this Part III, cell-survival measurements under aerobic and hypoxic conditions were made for various heavy particle beams. For heavy charged-particle beams, the measurements were made at the beam entrance (plateau), peak centre (10 cm wide peaks), and distal peak (1 cm from dose fall-off). Chinese hamster cells (V79) were used. Metabolic depletion was used to obtain hypoxia. The results indicate that the differences in RBE between the entrance region and peak are not very large when the Bragg peaks are broadened to 10 cm. The RBE for argon ions remains the same at the entrance and peak centre, and the RBE at the distal side of the Bragg peak is significantly reduced compared to the peak centre and entrance region because of saturation effects at high LET. The OER for protons is not significantly different from that for X rays. The OER for helium ions, carbon ions, and negative pions is larger, for neon ions is similar, and for argon ions is smaller when compared with fast neutrons. The OER values for heavy ions are higher than expected and could be due to a large delta-ray penumbra associated with the energy deposited by energetic heavy ions. The oxygen effect may depend upon energy deposition over distances of the order of nanometers.

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Section: Resultssupporting

confidence: 68%

A heavy particle comparative study. Part III: OER and RBE

Raju¹,

Amols²,

Bain³

et al. 1978

BJR

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“…Another set of data for a wide range of LET values from which information on the LET dependence of SLD can be derived has been published by Chapman et al (58,59). Single-dose survival curves for Chinese hamster V79 cells in plateau phase and in G, phase were obtained for ion beams of helium, carbon, neon and argon.…”

Section: Single-track Lethal Damage As a Function Of Letmentioning

confidence: 99%

The Relationships between RBE and LET for Different Types of Lethal Damage in Mammalian Cells: Biophysical and Molecular Mechanisms

Barendsen¹

1994

Radiation Research

100

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The relative biological effectiveness (RBE) of radiations as a function of linear energy transfer (LET) is analyzed for different types of damage causing reproductive death of mammalian cells. Survival curves are evaluated assuming a linear-quadratic dose dependence of the induction of reproductive death of cells. The linear term represents damage from single particle tracks and the quadratic term represents damage due to interaction of lesions from independent tracks. Differences and similarities are discussed of the LET dependence of single-track lethal damage, sublethal damage, potentially lethal damage and DNA double-strand breaks. The RBE-LET relationships are correlated with local energy deposition in small regions of the cells. The analysis shows that single-track lethal damage is composed in part of a type of damage that is not repaired by delayed plating and is very strongly dependent on LET with maximum RBE values up to 20, while another component consists of potentially lethal damage that is weakly dependent on LET with maximum RBE values less than 3. Potentially lethal damage and sublethal damage depend similarly on LET as DNA double-strand breaks. The sector of single-track damage which is not repaired by delayed plating is hypothesized to be caused through a repair-exchange mechanism involving two double-strand breaks induced close together. The identification of these different components of damage leads to an interpretation of differences in radiosensitivity and in RBE-LET relationships among various types of cells.

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“…This implies that the LET dependence of the beta values might discriminate normal cells/tissue and malignant cells/tissues. Equally possible is an alternative implication that beta would rather be independent of the LET [16,17].…”

Section: Discussionmentioning

confidence: 95%