Radioactive <sup>198</sup>Au-Doped Nanostructures with Different Shapes for <i>In Vivo</i> Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

Black, Kathleen; Wang, Yucai; Luehmann, Hannah; Cai, Xiaoxiao; Xing, Weihong; Pang, Bo; Zhao, Yongfeng; Cutler, Cathy S.; Wang, Lihong V.; Liu, Yongjian; Xia, Younan

doi:10.1021/nn406258m

Cited by 322 publications

(295 citation statements)

References 41 publications

(90 reference statements)

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“…These instabilities may induce false target detection, which decreases the accuracy of diagnostic information. Therefore, functionalization methods free of chelating agents have been sought recently as a way to overcome those drawbacks [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Radionuclide-labeled nanostructures for In Vivo imaging of cancer

et al. 2015

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Molecular imaging plays an important role in the non-invasive diagnosis and the guiding or monitoring of disease treatment. Different imaging modalities have been developed, and each method possesses unique strengths. While a variety of molecules have been used previously in nuclear imaging, the exceptional properties of nanostructures in recent research enable the deployment of accurate and efficient diagnostic agents using radionuclide-nanostructures. This review focuses on the radionuclide labeling strategies of various nanostructures and their applications for multimodality tumor imaging.

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Section: Introductionmentioning

confidence: 99%

Radionuclide-labeled nanostructures for In Vivo imaging of cancer

et al. 2015

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“…Xia et al investigated shape-effect on in vivo behaviors of gold nanostructures and found that nanospheres have longer blood circulation and higher tumor uptake over other shaped Au nanostructures. [4] Moreover, various surface chemistries have been widely used to manipulate in vivo behaviors of nanomedicines. [5] * jiezheng@utdallas.edu.…”

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confidence: 99%

“…To create more metal NPs with the same size and surface coating but different core densities, we also synthesized Au-Ag alloy NPs through co-reduction method. Briefly, HAuCl 4 and AgNO 3 solution were mixed at molar ratios of 1:1.3 and 1:1, respectively, followed by chemical reduction with freshly prepared NaBH 4 solution (0.5M) in the presence of GS in 4 ml distilled water at room temperature. After purification, glutathione coated Au-Ag NPs (GSAu/AgNPs) with ~3.1 nm HD were obtained.…”

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confidence: 99%

Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density

Tang

Peng

et al. 2016

Angewandte Chemie

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Identifying key factors that govern in vivo behaviors of nanomaterials is critical to future clinical translation of nanomedicines. Shadowed by size-, shape-and surface-chemistry effects, the impact of particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities as model, we found that both renal clearance and passive tumor targeting of the NPs are strongly correlated with their densities: with the decrease of particle density, renal-clearance efficiency exponentially increased in the early elimination phase but passive tumor targeting was linearly decreased. Through systematic investigation on their pharmacokinetics, biodistribution and kidney filtration, we found that lower density NPs more easily distribute in the body and have shorter retention in highly permeable organs such as kidneys than the higher ones. These density-dependent in vivo behaviors are likely due to the fact that high-density AuNPs marginated to the blood vessel walls more quickly than low-density NPs; as a result, they circulated slowly in the laminar blood flow than the low-density ones. These new findings highlight the importance of particle density in tailoring of in vivo behaviors of engineering NPs and might open up a new pathway for designing nanomedicines with desired functionalities together with other key factors.Unraveling key factors that are involved in nano-bio interactions in vivo is fundamental importance of translating nanomedicines into the clinics. [1] In the past decades, size, shape and surface chemistry of inorganic NPs have found to significantly affect their in vivo behaviors. [2] For example, Chan et al. found that gold nanoparticles (AuNPs) with different sizes show distinct tumor uptakes and penetration depths. [3] Among the AuNPs with sizes ranging from 20 to 100 nm, the small 20 nm AuNPs exhibited the lower accumulation but larger penetration depth in the tumor than others. Xia et al. investigated shape-effect on in vivo behaviors of gold nanostructures and found that nanospheres have longer blood circulation and higher tumor uptake over other shaped Au nanostructures. [4] Moreover, various surface chemistries have been widely used to manipulate in vivo behaviors of nanomedicines. [5] * jiezheng@utdallas.edu. On an even smaller size scale, however, whether density can still significantly affect in vivo behaviors of inorganic NPs with different compositions is not clear even though they exhibited distinct clearance efficiency and tumor targeting. [7] For instance, Choi et al. systematically investigated renal clearance of cysteine coated CdSe/ZnS quantum dots (QDs) and found that almost all the 4.36 nm QDs can be renally cleared within 24 h after intravenous injection. [8] Similar to these QDs, silica NPs also exhibited very high renal clearance efficiencies: about 70 percent of injected dose (%ID) of silica NPs was excreted in urine at 24 h post...

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“…1 Recently, Wang et al labeled gold nanoparticles with a radioisotope of gold, 198 Au, and imaged their distribution by detecting Cerenkov luminescence from the radioisotopes. 7,8 Their techniques offer real-time in vivo images for visualizing the distribution of metal nanoparticles in organs and tumor tissues. However, because of limited spatial resolution, detailed distributions within a tissue are not clear.…”

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confidence: 99%