Imaging Mass Spectrometry of Gold Nanorods Distributed in Tumor Tissues

Niidome, Takuro; Fujii, Masanori; Nakashima, Naotoshi; Katayama, Yoshiki; Niidome, Yasuro

doi:10.1246/cl.150258

Cited by 13 publications

(5 citation statements)

References 14 publications

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“…GNR nanomaterials were characterized using their solution color, UV-visible absorption spectra, and TEM, confirming their successful synthesis [21][22][23]. They were then characterized using TEM, UV-visible absorption spectroscopy, Fourier transform infrared spectroscopy, and STEM-EDS specta [24][25][26][27], which proved the successful synthesis by coating Cu-MOF on the GNR surface. Finally, GMD was characterized by transmission electron microscopy and STEM-EDS, and the results proved that GMD nanomaterials have drug-carrying capacity, as we successfully loaded DOX (Figure S3).…”

Section: Discussionmentioning

confidence: 70%

Metal–Organic Framework-Capped Gold Nanorod Hybrids for Combinatorial Cancer Therapy

Zhao,

Liu,

Huang

et al. 2024

Molecules

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Recently, nanomaterials have attracted extensive attention in cancer-targeting therapy and as drug delivery vehicles owing to their unique surface and size properties. Multifunctional combinations of nanomaterials have become a research hotspot as researchers aim to provide a full understanding of their nanomaterial characteristics. In this study, metal–organic framework-capped gold nanorod hybrids were synthesized. Our research explored their ability to kill tumor cells by locally increasing the temperature via photothermal conclusion. The specific peroxidase-like activity endows the hybrids with the ability to disrupt the oxidative balance in vitro. Simultaneously, chemotherapeutic drugs are administered and delivered by loading and transportation for effective combinatorial cancer treatment, thereby enhancing the curative effect and reducing the unpredictable toxicity and side effects of large doses of chemotherapeutic drugs. These studies can improve combinatorial cancer therapy and enhance cancer treatment.

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Section: Discussionmentioning

confidence: 70%

Metal–Organic Framework-Capped Gold Nanorod Hybrids for Combinatorial Cancer Therapy

Zhao,

Liu,

Huang

et al. 2024

Molecules

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“…Gold nanoparticles have been developed as a mass probe for imaging mass spectrometry of tissue sections using a conventional mass spectrometer designed for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). 1,[3][4][5][6][7][8][9][10] The irradiation of 355-nm pulsed-laser light in a MALDI-MS instrument causes preferential desorption of gold cations (Au + , Au2 + , Au3 + ) in the absence of matrix molecules. The gold cations act as reporter ions to represent the distribution of target molecules.…”

Section: Introductionmentioning

confidence: 99%

Anionic gold ions desorbed from gold nanorods and nanospheres

Nishi

Niidome

2022

ANAL. SCI.

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Desorption and ionization of gold anions and cations from gold nanorods and nanospheres were investigated using a matrix-assisted laser desorption/ionization mass spectrometry instrument. The signal intensities of the gold anions from nanorods with a volume of 4.8 × 10 3 nm 3 were about 28 times larger than the signal intensities of gold anions from nanospheres of similar volume. Gold cations did not show a remarkable difference depending on the nanoparticles' shapes. The unique desorption behavior of gold anions suggests their potential as reporter ions in mass spectrometry.

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“…Novel applications through exacting surface modification with functional molecules are expected to enable further breakthroughs in gold nanorod applications. 54,55 Gold Nanocages. Xia and his co-workers prepared gold nanocages using galvanic replacement reactions of silver nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Anisotropic Gold-based Nanoparticles: Preparation, Properties, and Applications

2016

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Among the several types of nanoparticles in existence, anisotropic gold-based nanoparticles demonstrate special advantages because of their unique properties. Gold nanoparticles can be prepared and modified with a wide range of functional materials including polymers, surfactants, ligands, dendrimers, drugs, DNA, RNA, proteins, peptides, and oligonucleotides. Hence, they are a promising vehicle for bioimaging, drug delivery, and other therapies. This review mainly addresses the properties, preparation, and applications of anisotropic gold nanoparticles in biomedical applications and targeted drug delivery.

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Imaging Mass Spectrometry of Gold Nanorods Distributed in Tumor Tissues

Cited by 13 publications

References 14 publications

Metal–Organic Framework-Capped Gold Nanorod Hybrids for Combinatorial Cancer Therapy

Metal–Organic Framework-Capped Gold Nanorod Hybrids for Combinatorial Cancer Therapy

Anionic gold ions desorbed from gold nanorods and nanospheres

Anisotropic Gold-based Nanoparticles: Preparation, Properties, and Applications

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