Radio-protective response on the environmental pollutant induced oxidative stress

Gharib, Ola A.; Ellatif, Usama A. Abd; Abdellah, Nadia M.; Mohammad, Marwa A.

doi:10.4236/abb.2012.327122

Cited by 4 publications

(3 citation statements)

References 39 publications

(34 reference statements)

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“…Concerning the hepatoprotective efficacy of LDR, the obtained results are in agreement with previous studies. 17,43,44 The ameliorative effect of LDR might be correlated to LDR-induced hormetic response in cells 45 and the ability of LDR (up to 0.5 Gy) to stimulate resistance of cells to oxygen radicals’ toxicity, which is reflected on improved liver enzymes.…”

Section: Discussionmentioning

confidence: 99%

Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats

2016

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This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose γ-radiation (LDR; 0.25 Gy, twice the total dose of 0.5 Gy at the 1st and 3rd day, respectively) was evaluated against TAA (300 mg/kg, intraperitoneal × 3) induced liver damage and HE in rats. Serum aspartate transaminase, alanine transaminase, γ-glutamyltransferase, total bilirubin, ammonia, and manganese were estimated to evaluate liver function. In addition, malondialdehyde (MDA) as well as reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) were determined to assess antioxidant capacity in liver tissue. Moreover, hepatic apoptotic markers (cysteine-dependent aspartate-directed proteases 3, 8 (caspase-3, 8) and cytochrome C) were estimated to indicate hepatic apoptosis. HE was evaluated through the determination of whole brain ammonia, manganese, MDA, GSH, GPX, SOD, CAT, and caspase-3. The cognitive and locomotor deficits were assessed via step through passive avoidance test, activity cage (actophotometer), γ-aminobutyric acid, and N-methyl-d-aspartate/adenosine triphosphate–neuronal nitric oxide synthase/nitric oxide–cyclic guanosine monophosphate axis in rats’ cerebella and hippocampi. The involvement of hypoxia inducible factor-1α, aquaporine-4, and matrix metalloproteinase 9 in association with the brain water content (%) in the whole brain as an index for brain edema was also evaluated. The obtained results showed a marked amelioration of the aforementioned biochemical parameters and behavioral tasks which is supported by histopathological and immunohistochemical examination. It could be concluded that Daflon and LDR afforded hepatoprotection and neuroprotection against TAA-induced acute liver damage and HE.

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Section: Discussionmentioning

confidence: 99%

Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats

2016

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“…Health impacts of ionizing radiation are quite variable, although it is commonly known that a high dose is detrimental and can kill living organism, low doses of radiation are significant and can be profitable to health 20‐22 . Previous studies showed that low dose rate of ionizing radiation enhances body immune system, antitumor ability, antioxidant activities, speed oxidative stress recovery caused by chemotherapy and increases resistance to high‐ dose radiation 23‐25 …”

Section: Introductionmentioning

confidence: 99%

“…[20][21][22] Previous studies showed that low dose rate of ionizing radiation enhances body immune system, antitumor ability, antioxidant activities, speed oxidative stress recovery caused by chemotherapy and increases resistance to high-dose radiation. [23][24][25] All these taken into consideration, the aim of the present study, is…”

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confidence: 99%

Amphora algae with low‐level ionizing radiation exposure ameliorate D‐galactosamine‐induced inflammatory impairment in rat kidney

El-Sonbaty

Moawed

Elbakry

2020

Environmental Toxicology

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d‐Galactosamine (d‐GalN) is a well‐known toxin that causes many metabolic and morphological abnormalities resulting in advanced renal failure and liver damage. Occupational exposure to low‐level ionizing radiation (<1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. The present study was therefore aimed to investigate the protective impact of Amphora coffaeiformis extract and low dose gamma radiation against d‐GalN induced renal damage in rats. Forty‐eight adult male Swiss albino rats were distributed equally into eight groups. The measurements included antioxidants activities (superoxide dismutase, catalase and glutathione peroxidase) as well as lipid peroxidation level in kidney tissue. Also, kidney function tests and inflammatory markers (tumor necrosis factor alpha and nuclear factor kappa‐light‐chain‐enhancer of activated B cells) were measured. Additionally, relative quantification of kidney nuclear factor erythroid 2‐related factor 2 (Nrf‐2) gene was estimated. Histopathological examination was also performed in kidney tissue. The results revealed decreases in antioxidant activities and downregulation of Nrf‐2 expression accompanied by increases in lipid peroxidation level, kidney function tests and inflammatory markers in d‐GaIN group. The treatment with Amphora algal extract and low dose gamma radiation ameliorated the previous measurements which were harmony with histopathological findings. In conclusion, A coffaeiformis extract and low dose gamma radiation provided marked functional and histological effects in the treating acute renal damage induced by d‐GalN in rats.

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Long-term effects of low-dose mouse liver irradiation involve ultrastructural and biochemical changes in hepatocytes that depend on lipid metabolism

Łysek-Gładysińska

Wieczorek

Walaszczyk

et al. 2018

Radiat Environ Biophys

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The aim of the study was to investigate long-term effects of radiation on the (ultra)structure and function of the liver in mice. The experiments were conducted on wild-type C57BL/6J and apolipoprotein E knock-out (ApoE) male mice which received a single dose (2 or 8 Gy) of X-rays to the heart with simultaneous exposure of liver to low doses (no more than 30 and 120 mGy, respectively). Livers were collected for analysis 60 weeks after irradiation and used for morphological, ultrastructural, and biochemical studies. The results show increased damage to mitochondrial ultrastructure and lipid deposition in hepatocytes of irradiated animals as compared to non-irradiated controls. Stronger radiation-related effects were noted in ApoE mice than wild-type animals. In contrast, radiation-related changes in the activity of lysosomal hydrolases, including acid phosphatase, β-glucuronidase, N-acetyl-β-D-hexosaminidase, β-galactosidase, and α-glucosidase, were observed in wild type but not in ApoE-deficient mice, which together with ultrastructural picture suggests a higher activity of autophagy in ApoE-proficient animals. Irradiation caused a reduction of plasma markers of liver damage in wild-type mice, while an increased level of hepatic lipase was observed in plasma of ApoE-deficient mice, which collectively indicates a higher resistance of hepatocytes from ApoE-proficient animals to radiation-mediated damage. In conclusion, liver dysfunctions were observed as late effects of irradiation with an apparent association with malfunction of lipid metabolism.

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Radio-protective response on the environmental pollutant induced oxidative stress

Abstract: The purpose of this study was to investigate the protective effect of low dose radiation on TCE induced oxidative damage in rats. The oxidative damage of both liver and kidney was assessed by serum alkaline phosphatase (

Cited by 4 publications

References 39 publications

Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats

Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats

Amphora algae with low‐level ionizing radiation exposure ameliorate D‐galactosamine‐induced inflammatory impairment in rat kidney

Long-term effects of low-dose mouse liver irradiation involve ultrastructural and biochemical changes in hepatocytes that depend on lipid metabolism

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