Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood

Shirazi, Alireza; Mihandoost, Ehsan; Mohseni, Mehran; Ghazi‐Khansari, Mahmoud; Mahdavi, Seied Rabi

doi:10.1016/j.ejmp.2011.11.007

Cited by 36 publications

(22 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to stroke, the efficacy of melatonin in inhibiting oxidative damage has also been tested in a variety of neurological disease models where free radicals have been implicated as being at least partial causal agents of the condition. Thus, melatonin has been shown to reduce Aβ protein toxicity in AD animal models (Dragicevic et al, 2011;Matsubara et al, 2003;Olcese et al, 2009;Pappolla et al, 1997), to reduce oxidative damage in several models of PD (Acuña- Castroviejo-Castroviejo et al, 1997;Chuang and Chen, 2004;Dabbeni-Sala et al, 2001;Jin et al, 1998;Saravanan et al, 2007;Singhal et al, 2010), to protect against glutamate excitotoxicity (Das et al, 2010;Giusti et al, 1996a) and to lower neural damage due to cadmium toxicity (Jiménez-Ortega et al, 2011;Poliandri et al, 2006), δ-aminolevulinic acid toxicity (porphyria) (Carneiro and Reiter, 1998;Onuki et al, 2005;Princ et al, 1997), hyperbaric hyperoxia (Pablos et al, 1997;Shaikh et al, 1997), brain trauma (Beni et al, 2004;Kabadi and Maher, 2010;Tsai et al, 2011), γ radiation (Erol et al, 2004;Shirazi et al, 2011;Taysi et al, 2008), focal ischemia (Kilic et al, 2011;Koh, 2012;Lee et al, 2004;Tai et al, 2011) and a variety of neural toxins (Reiter et al, 2010).…”

Section: Melatonin and Neuronal Damagementioning

confidence: 99%

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

et al. 2012

View full text Add to dashboard Cite

The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeostasis, retinal neuromodulation and vasomotor responses. It scavenges hydroxyl, carbonate and various organic radicals as well as a number of reactive nitrogen species. Melatonin also enhances the antioxidant potential of the cell by stimulating the synthesis of antioxidant enzymes including superoxide dismutase, glutathione peroxidase and glutathione reductase, and by augmenting glutathione levels. Melatonin preserves mitochondrial homeostasis, reduces free radical generation and protects mitochondrial ATP synthesis by stimulating Complex I and IV activities. The decline in melatonin production in aged individuals has been suggested as one of the primary contributing factors for the development of age-associated neurodegenerative diseases. The efficacy of melatonin in preventing oxidative damage in either cultured neuronal cells or in the brains of animals treated with various neurotoxic agents, suggests that melatonin has a potential therapeutic value as a neuroprotective drug in treatment of Alzheimer´s disease (AD), Parkinson´s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington´s disease (HD), stroke and brain trauma. Therapeutic trials with melatonin indicate that it has a potential therapeutic value as a neuroprotective drug in treatment of AD, ALS and HD. In the case of other neurological conditions, like PD, the evidence is less compelling. Melatonin's efficacy in combating free radical damage in the brain suggests that it can be a valuable therapeutic agent in the treatment of cerebral edema following traumatic brain injury or stroke. Clinical trials employing melatonin doses in the range of 50-100 mg/day are warranted before its relative merits as a neuroprotective agent is definitively established.

show abstract

Section: Melatonin and Neuronal Damagementioning

confidence: 99%

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Another important mechanism for the antioxidative effect of melatonin is the stimulation of the genes and enzymes such as Nrf2, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and glutathione reductase (GR) (Reiter et al 1998;Kotler et al 1998;Rodriguez et al 2004;Kireev et al 2007;Kleszczyński et al 2016), all of which assist with detoxification. Because the inhibition of antioxidant enzymes is an important effect of ionizing radiation in both irradiated and out-of-field organs, this property of melatonin may augment the scavenging of free radicals produced by radiation (Najafi et al 2016;Shirazi et al 2013).…”

Section: Antioxidative Effects Of Melatoninmentioning

confidence: 99%

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

View full text Add to dashboard Cite

Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs. These effects are mediated through various modulatory effects of melatonin in different levels of tissue reaction to ionizing radiation. The effects on the DNA repair system, antioxidant enzymes, immune cells, cytokines secretion, transcription factors, and protein kinases are most important. Moreover, anti-cancer properties of melatonin may increase the therapeutic ratio of radiotherapy. Clinical applications of this agent for the management of malignancies such as breast cancer have shown promising results. It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of melatonin that may help to improve response of the tumor to radiotherapy. In this review, the effects of melatonin on the modulation of immune responses in both normal and tumor tissues will be discussed.

show abstract

“…We concluded that 10 mg/kg melatonin is likely to be an adequate concentration for significant protection against lower dose of 2 Gy (Figures 1 and 2), while it does not offer significant protection against higher dose of 8 Gy. Therefore, it seems that radioprotective effects of melatonin are dose-dependent [14]. Moreover, our new data obtained from other studies showed that radiation exposure decreased levels of GSH and increased levels of MDA in the lens and liver (Figures 3 and 4) of rats, but these values were within normal limits when melatonin was administered [40, 41].…”

Section: Antioxidative Effect Of Melatoninmentioning

confidence: 93%

“…Treatment with melatonin (10 mg/kg) ameliorates harmful effects of irradiation by increasing lymphocytes count (LC) as well as antioxidant enzymes activity and decreasing nitric oxide (NO) levels at all time points [14]. We concluded that 10 mg/kg melatonin is likely to be an adequate concentration for significant protection against lower dose of 2 Gy (Figures 1 and 2), while it does not offer significant protection against higher dose of 8 Gy.…”

Section: Antioxidative Effect Of Melatoninmentioning

confidence: 99%

See 1 more Smart Citation

Can Melatonin Help Us in Radiation Oncology Treatments?

Mihandoost

Shirazi

Mahdavi

et al. 2014

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Nowadays, radiotherapy has become an integral part of the treatment regimen in various malignancies for curative or palliative purposes. Ionizing radiation interacts with biological systems to produce free radicals, which attack various cellular components. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the harmful effects of radiation. Melatonin has been shown to be both a direct free radical scavenger and an indirect antioxidant by stimulating antioxidant enzymes and suppressing prooxidative enzymes activity. In addition to its antioxidant property, there have also been reports implicating antiapoptotic function for melatonin in normal cells. Furthermore, through its antitumor and radiosensitizing properties, treatment with melatonin may prevent tumor progression. Therefore, addition of melatonin to radiation therapy could lower the damage inflicted to the normal tissue, leading to a more efficient tumor control by use of higher doses of irradiation during radiotherapy. Thus, it seems that, in the future, melatonin may improve the therapeutic gain in radiation oncology treatments.

show abstract

Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood

Cited by 36 publications

References 32 publications

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

The melatonin immunomodulatory actions in radiotherapy

Can Melatonin Help Us in Radiation Oncology Treatments?

Contact Info

Product

Resources

About