Radicals in Berkeley?

Linn, Stuart

doi:10.1074/jbc.x115.644989

Cited by 1 publication

(1 citation statement)

References 24 publications

(19 reference statements)

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“…[118][119] Scavenging free CoA-byA TP:citrate lyase or phosphotransacetylase, for example-leads to inhibition of the FAS, preventing ap roof-reading functiono ft he MATd omain. [120] In addition to the CoA level, the concentrations of acyl-CoAsa lso play an important role in fatty acidb iosynthesis. Owing to the bifunctional role of the MATd omain, the priming acetyl and elongating malonyl moieties competef or FASl oading.…”

Section: Animal Type If Assmentioning

confidence: 99%

Fatty Acid Biosynthesis: Chain‐Length Regulation and Control

et al. 2019

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De novo biosynthesis of fatty acids is an iterative process requiring strict regulation of the lengths of the produced fatty acids. In this review, we focus on the factors determining chain lengths in fatty acid biosynthesis. In a nutshell, the process of chain‐length regulation can be understood as the output of a chain‐elongating C−C bond forming reaction competing with a terminating fatty acid release function. At the end of each cycle in the iterative process, the synthesizing enzymes need to “decide” whether the growing chain is to be elongated through another cycle or released as the “mature” fatty acid. Recent research has shed light on the factors determining fatty acid chain length and has also achieved control over chain length for the production of the technologically interesting short‐chain (C4–C8) and medium‐chain (C10–C14) fatty acids.

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Section: Animal Type If Assmentioning

confidence: 99%