Radical Scavenging Actions and Immunomodulatory Activity of Aronia melanocarpa Propylene Glycol Extracts

Abstract

Researchers are attracted to the wide-ranging, useful components in Aronia melanocarpa berries. They are searching for the most effective ways to extract the active substances that can enhance the body’s protective properties. The current study presents detailed information about the extracts from A. melanocarpa fruits frozen and dried under mild conditions and their chemical composition. In Wistar rats with induced immunosuppression, the effect of chokeberry fruit extracts on the leukocyte formula, phagocytic activity, and cytokine system was studied. It was shown that the A. melanocarpa frozen fruit extract contains more anthocyanins, sugars, and ascorbic acid, and has a more pronounced antioxidant activity determined by the ability to bind APPH-radicals. Moreover, the extract showed membrane-protective and cytoprotective properties against RPMI-1788 cell line. The extract from dried raw material shows a higher antioxidant activity due to the ability to bind DPPH-radicals. It was revealed that extracts from A. melanocarpa fruits promote rapid immune system recovery in rats, normalize the leukocyte count, and improve monocyte and neutrophil phagocytic indicators. Research on the cytokine profile revealed that the anti-inflammatory properties in A. melanocarpa extracts were more pronounced in dried extracts. For several cytokines, a normalization of quantity was noted.

Antioxidative and Immunomodulating Properties of Aronia melanocarpa Extract Rich in Anthocyanins

“…In a previous study, we reported the method of preparation, extraction and characterization and the antioxidant and immunomodulating activity of Aronia melanocarpa berry extracts [ 16 ]. However, knowledge of the extract’s chemical composition is a prerequisite for the study of its potential mechanisms as well as the correlation between the content of bioactive substances and their activity [ 17 ].…”

Bioactivity of Aronia Products, and The Promising Use of Aronia in Dairy Industry

“…Aronia extracts promoted rapid immune system recovery in Wistar rats, normalized the leukocyte count, and improved monocyte and neutrophil phagocytic indicators (Bushmeleva et al, 2021).…”

A review on the potential use of natural products in overweight and obesity

“…The Phyllanthus emblica fruits were ground and macerated twice with 70% ethanol at room temperature for 3 days, the ethanolic extract was filtered and concentrated to obtain about 5–6% total yield (Balusamy et al, 2020). It was reported that the ethanol Aronia melanocarpa extract showed good antiobesity activity, while 1.3‐propylene glycol Aronia melanocarpa extract exhibited antiinflammatory activity (Bushmeleva et al, 2021; Kim et al, 2019a; Lee et al, 2021). In addition, the butanol extract of Moringa oleifera leaves showed the strongest potential antioxidant, antibacterial, and cytotoxic activities, whereas the 70% ethanol extract of Moringa oleifera leaves with total yield about 5–6% could reduce adipocyte formation by promoting apoptosis (Bennour et al, 2021; Fouré et al, 2018).…”

“…Aronia melanocarpa extract exhibited antiinflammatory activity (Bushmeleva et al, 2021;Kim et al, 2019a;Lee et al, 2021). In addition, the butanol extract of Moringa oleifera leaves showed the strongest potential antioxidant, antibacterial, and cytotoxic activities, whereas the 70% ethanol extract of Moringa oleifera leaves with total yield about 5-6% could reduce adipocyte formation by promoting apoptosis (Bennour et al, 2021;Fouré et al, 2018) (Wang et al, 2017).…”