Radical prostatectomy in patients infected with human immunodeficiency virus

Huang, William C.; Kwon, Eric O.; Scardino, Peter T.; Eastham, James A.

doi:10.1111/j.1464-410x.2006.06271.x

Cited by 24 publications

(22 citation statements)

References 32 publications

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“…Some authors have suggested that PCa may be more aggressive in patients with HIV; although this study has a limited number of HIV-positive patients with high CD4 counts and low viral loads, it does not support these assertions. 25 The findings of Huang et al 21 were similar to ours (although with a smaller series, different surgical approach and longer follow-up): negative surgical margins in five patients with known HIV who underwent open radical retropubic prostatectomy. No patients had biochemical recurrence after a median follow-up of 26 months.…”

Section: Ralp In Men With Hiv Jl Silberstein Et Alsupporting

confidence: 76%

“…[19][20] Radical retropubic prostatectomy, 21 laparoscopic radical prostatectomy, 22 cryosurgery, 22 external beam radiation therapy, 23 brachytherapy 24 and active surveillance 22 have been reported for HIVpositive men with localized PCa and found to be generally safe and efficacious in the short term. 17 The oncological risk posed by PCa in the HIV-positive cohort did not differ significantly from the non-HIVpositive cohort, based on a variety of prognostic data including PSA value, clinical tumor stage, biopsy Gleason sum, D'Amico risk stratification and pathological tumor grade or stage.…”

Section: Ralp In Men With Hiv Jl Silberstein Et Almentioning

confidence: 99%

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Robot-assisted laparoscopic radical prostatectomy in men with human immunodeficiency virus

Silberstein

Parsons

Palazzi-Churas

et al. 2010

Prostate Cancer Prostatic Dis

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The aim of this study is to evaluate the outcomes of robot-assisted laparoscopic prostatectomy (RALP) in prostate cancer (PCa) patients with human immunodeficiency virus (HIV). This is a prospective cohort study of HIV patients undergoing RALP, comparing the demographics, tumor characteristics, complications, and short-term oncological outcomes of HIV-positive men to HIV-negative men using univariate (v 2 , Mann-Whitney test) and multivariable (logistic regression) analyses. From 2007 to 2010, 298 men underwent RALP, 8 of whom were known to be HIV positive. Preoperatively, all eight were taking highly active antiretroviral therapy (HAART) and had undetectable viral loads (o50); mean CD4 count was 634 cells per mm 3 . HIV-positive men were younger (54 versus 62 years, P ¼ 0.010) and less likely to be white (P ¼ 0.007). There were no significant differences between groups with respect to clinical staging, pathological and oncological outcomes or most complication rates. However, the prevalence of perioperative transfusions (P ¼ 0.031) and ileus (P ¼ 0.021) were higher in HIV-positive patients. HIV remained significantly associated with risk of transfusion after adjustment for age, race, Gleason sum and clinical T stage (P ¼ 0.002). After a median of 2.6 (range 0.03-19.2) months of follow-up, PSA remained undetectable in all eight HIV patients. These data suggest that RALP is safe for, and demonstrates short-term oncological efficacy in, HIV-positive patients with PCa.

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Section: Ralp In Men With Hiv Jl Silberstein Et Alsupporting

confidence: 76%

Section: Ralp In Men With Hiv Jl Silberstein Et Almentioning

confidence: 99%

Robot-assisted laparoscopic radical prostatectomy in men with human immunodeficiency virus

Silberstein

Parsons

Palazzi-Churas

et al. 2010

Prostate Cancer Prostatic Dis

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“…HIV-positive men with biopsy-proven localized PCa have undergone a variety of interventions; Huang et al 13 have published the largest series of radical prostatectomies in HIV-positive individuals to our knowledge. They retrospectively reviewed all patients who had undergone prostatectomy at Memorial SloanKettering Cancer Center over a two-and-a-half-year period and identified five men who had HIV before prostatectomy.…”

Section: Radical Prostatectomymentioning

confidence: 99%

HIV and prostate cancer: a systematic review of the literature

Silberstein

Downs

Lakin

et al. 2008

Prostate Cancer Prostatic Dis

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Malignancy occurs with increased frequency in the HIV-positive population. The true incidence of prostate cancer in this population is unknown. In the few cases that have been presented in the literature, prostate cancer in HIV-positive men appears to behave much like it does in HIV-negative men. Prostate cancer is the most common malignancy in men and the second leading cause of cancer death. Approximately 800 000 men in the United States are HIV positive, and innovative therapies have dramatically improved survival. HIV disproportionately impacts ethnic groups with increased risk of prostate cancer and has been associated with increases in the incidence of certain malignancies. Despite the high prevalence of both diseases, there is relatively little literature about prostate cancer in HIV-positive patients. There is no consensus on how to screen or treat this patient population. We review the literature with regards to incidence, screening, treatment, and outcomes of this poorly characterized population. We briefly discuss the impact of highly active antiretroviral therapy and testosterone supplementation in the development of prostate cancer. A systematic review of the literature was conducted using MEDLINE key words 'HIV,' 'prostate,' 'prostate cancer' and 'AIDS.' Manual bibliographic review of cross-referenced items was also performed. A total of 176 unique abstracts and publications were reviewed; many authors provided data on the incidence of HIV and various malignancies including prostate cancer. Twelve unique publications providing detailed information on 60 patients with HIV and prostate cancer were identified. Prostate cancer is a common malignancy in HIV-positive men. With improved therapies for HIV and increasing survival, the importance for screening and treating prostate cancer is increasing. Acute outcomes of treatment do not demonstrate increased acute morbidity; however long-term outcomes have not been reported.

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“…In early decades, surgeons were hesitant to perform elective and emergency procedures to this group of patients due to high complication rates (3,6). The development of HAART in the mid-1990s, presented as the cornerstone for the decrease of the morbidity and mortality rates associated with HIV infection in these patients.…”

Section: Discussionmentioning

confidence: 99%

Influence of HIV virus in the hospital stay and the occurrence of postoperative complications classified according to the Clavien-Dindo classification and in comparison with the Charlson Comorbidity Index in patients subjected to urologic and general surgery operations. Our preliminary results

Dimitroulis

Karaolanis

Katafigiotis³

et al. 2017

Arch Ital Urol Androl

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Objectives: From the first time that human immunodeficiency virus (HIV) was discovered, till today both the quality of life and survival expectancy of HIV-infected patients have markedly improved. As the life expectancy of these patients increases due to the use of highly active anti-retroviral therapy (HAART) also increases the number of HIV-positive patient to be subjected to an operation. Different studies have examined the occurrence of complications in this particular group of patients and their possible susceptibility to infections or other complications that could lead to increased hospital stay, morbidity and mortality with controversial results. Material and methods: We retrospectively analyzed the data of 25 HIV-patients that were subjected to general surgery and urologic operations and we also examined in comparison with the Charlson score and their comorbidities the occurrence of complications and subsequently the possibility of an increase hospital stay due to their HIV infection. Alongside we classified their complications according to the Clavien-Dindo and compared these complications in relation to their Charlson score and CD4 count. Results: 10/25 (40%) of the population had prolonged hospital stay and from this population 6 (6/25) (24%) patients had less than 200 CD4 constituting the AIDS subpopulation. The decline of the CD4 count showed a tendency for the occurrence of a complication and comorbidities to HIV-positive patients seem to affect more the AIDS subpopulation. Conclusions: Although this is a small retrospective study, we tried to classify our complications according to the Clavien- Dindo classification and combine the classification to the age adjusted Charlson score index of comorbidities.

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Radical prostatectomy in patients infected with human immunodeficiency virus

Cited by 24 publications

References 32 publications

Robot-assisted laparoscopic radical prostatectomy in men with human immunodeficiency virus

Robot-assisted laparoscopic radical prostatectomy in men with human immunodeficiency virus

HIV and prostate cancer: a systematic review of the literature

Influence of HIV virus in the hospital stay and the occurrence of postoperative complications classified according to the Clavien-Dindo classification and in comparison with the Charlson Comorbidity Index in patients subjected to urologic and general surgery operations. Our preliminary results

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