Influence of HIV virus in the hospital stay and the occurrence of postoperative complications classified according to the Clavien-Dindo classification and in comparison with the Charlson Comorbidity Index in patients subjected to urologic and general surgery operations. Our preliminary results

Dimitroulis, Dimitrios; Karaolanis, Georgios; Katafigiotis, Ioannis; Anastasiou, Ioannis; Palla, Viktoria–Varvara; Kontos, Athanasios; Duvdevani, Mordechai; Kontzoglou, Konstantinos

doi:10.4081/aiua.2017.2.125

Cited by 4 publications

(4 citation statements)

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“…Future studies, in which pre-mortem medical conditions are thoroughly documented, might consider applying alternative multimoribidity indexes, such as those that provide weights for more serious medical conditions 32,33 and which have been applied in specific contexts, such as HIV research. [34][35][36] Compared to tissues from uninfected individuals, those from HIV-positive individuals exhibit increased DNAmAge in kidney. HIV-1 infection is associated with an increased risk for a number of diseases and medical conditions typically associated with aging, including cardiovascular disease, osteoporosis, several cancers, kidney disease, liver disease, and cognitive decline [37][38][39][40][41][42][43][44][45][46][47][48][49] .…”

Section: Discussionmentioning

confidence: 99%

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HIV, Pathology and epigenetic age acceleration in different human tissues

Horvath

Lin

Kobor

et al. 2022

Preprint

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Background: Epigenetic clocks based on patterns of DNA methylation have great importance in understanding aging and disease; however, there are basic questions to be resolved in their application. It remains unknown whether epigenetic age acceleration (EAA) within an individual shows strong correlation between different primary tissue sites, the extent to which tissue pathology and clinical illness correlates with EAA in the target organ, and if EAA variability across tissues differs according to sex. Considering the outsized role of age-related illness in Human Immunodeficiency Virus-1 (HIV), these questions were pursued in a sample enriched for tissue from HIV-infected individuals. Methods: We used a custom methylation array to generate DNA methylation data from 661 samples representing 11 human tissues (adipose, blood, bone marrow, heart, kidney, liver, lung, lymph node, muscle, spleen, and pituitary gland) from 133 clinically-characterized, deceased individuals, including 75 infected with HIV. We developed a multimorbidity index based on the clinical disease history. Results: Epigenetic age was moderately correlated across tissues. Blood had the greatest number and degree of correlation, most notably with spleen and bone marrow. However, blood did not correlate with epigenetic age of liver. EAA in liver was weakly correlated with EAA in kidney, adipose, lung, and bone marrow. Clinically, hypertension was associated with EAA in several tissues, consistent with the multi-organ impacts of this illness. HIV infection was associated with positive age acceleration in kidney and spleen. Male sex was associated with increased epigenetic acceleration in several tissues. Preliminary evidence indicates that Amyotrophic Lateral Sclerosis is associated with positive EAA in muscle tissue. Finally, greater multimorbidity was associated with greater EAA across all tissues. Conclusion: Blood alone will often fail to detect EAA in other tissues. While hypertension is associated with increased EAA in several tissues, many pathologies are associated with organ-specific age acceleration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

HIV, Pathology and epigenetic age acceleration in different human tissues

Horvath

Lin

Kobor

et al. 2022

Preprint

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“…38,39 Some surgeons seem reluctant to operate on HIV-positive patients due to concerns regarding the risk of personal transmission of the virus and poor surgical outcomes. 15,16 This review reported that HIV-positive patients submitted to surgery for DSD have higher complication rates and conflicting data regarding surgical outcomes. No statistical differences in mortality were observed between HIV-negative and HIV-positive patients after degenerative cervical spine surgery.…”

Section: Surgical Cases In Hiv Patientsmentioning

confidence: 99%

“…[10][11][12][13] In spite of this, the incidence of spine surgery for DSD on HIV-positive patients seems to be low (0.23%), although it is not well determined. [14][15][16] The authors conducted a systematic review of clinical studies on surgery for DSD in HIV-positive patients. The main clinical questions to be answered in this review were if HIVpositive patients undergo less spine surgery and if they have poorer outcomes when compared with noninfected patients.…”

Section: Introductionmentioning

confidence: 99%

HIV and Surgery for Degenerative Spine Disease: A Systematic Review

Farias

Dagostini

Falavigna

2021

J Neurol Surg A Cent Eur Neurosurg

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Background and Study Aims The objective of this review is to evaluate the incidence of operative treatment, outcomes, and complications of surgery for degenerative spine disease (DSD) on human immunodeficiency virus (HIV) positive patients. Combined antiretroviral treatment led HIV patients to live long enough to develop many chronic conditions common in the uninfected population. Surgery for DSD is one of the most commonly performed neurosurgical procedures. However, the incidence of spine surgery for DSD in HIV-positive patients seems to be lower than that in uninfected individuals, although this has not been clearly determined. Methods A systematic search of the Medline, Web of Science, Embase, and SciElo databases was conducted. Only primary studies addressing DSD surgery on HIV-positive patients were included. Evaluated variables were rates of surgical treatment, surgical outcomes and complications, year of publication, country where study was conducted, type of study, and level of evidence. Results Six articles were included in the review from 1,108 records. Significantly lower rates of DSD surgery were identified in HIV-infected patients (0.86 per 1,000 patient-years) when compared with uninfected patients (1.41 per 1,000 patient-years). There was a significant increase in spinal surgery in HIV-positive patients over time, with a 0.094 incidence per 100,000 in the year 2000 and 0.303 in 2009. HIV-positive patients had very similar outcomes when compared with controls, with 66.6% presenting pain relief at a 3-month follow-up. Higher incidences of hospital mortality (1.6 vs. 0.3%; p < 0.001) and complications (12.2 vs. 9.5%, p < 0.001) were observed in HIV carriers. Conclusions HIV-positive individuals appear to undergo less surgery for DSD than HIV-negative individuals. Improvement rates appear to be similar in both groups, even though some complications appear to be more prevalent in HIV carriers. Larger studies are needed for decisive evidence on the subject.

show abstract

HIV, pathology and epigenetic age acceleration in different human tissues

et al. 2022

View full text Add to dashboard Cite

Epigenetic clocks based on patterns of DNA methylation have great importance in understanding aging and disease; however, there are basic questions to be resolved in their application. It remains unknown whether epigenetic age acceleration (EAA) within an individual shows strong correlation between different primary tissue sites, the extent to which tissue pathology and clinical illness correlate with EAA in the target organ, and if EAA variability across tissues differs according to sex. Considering the outsized role of age-related illness in Human Immunodeficiency Virus-1 (HIV), these questions were pursued in a sample enriched for tissue from HIV-infected individuals. We used a custom methylation array to generate DNA methylation data from 661 samples representing 11 human tissues (adipose, blood, bone marrow, heart, kidney, liver, lung, lymph node, muscle, spleen and pituitary gland) from 133 clinically characterized, deceased individuals, including 75 infected with HIV. We developed a multimorbidity index based on the clinical disease history. Epigenetic age was moderately correlated across tissues. Blood had the greatest number and degree of correlation, most notably with spleen and bone marrow. However, blood did not correlate with epigenetic age of liver. EAA in liver was weakly correlated with EAA in kidney, adipose, lung and bone marrow. Clinically, hypertension was associated with EAA in several tissues, consistent with the multiorgan impacts of this illness. HIV infection was associated with positive age acceleration in kidney and spleen. Male sex was associated with increased epigenetic acceleration in several tissues. Preliminary evidence indicates that amyotrophic lateral sclerosis is associated with positive EAA in muscle tissue. Finally, greater multimorbidity was associated with greater EAA across all tissues. Blood alone will often fail to detect EAA in other tissues. While hypertension is associated with increased EAA in several tissues, many pathologies are associated with organ-specific age acceleration.

show abstract

Influence of HIV virus in the hospital stay and the occurrence of postoperative complications classified according to the Clavien-Dindo classification and in comparison with the Charlson Comorbidity Index in patients subjected to urologic and general surgery operations. Our preliminary results

Cited by 4 publications

References 15 publications

HIV, Pathology and epigenetic age acceleration in different human tissues

HIV, Pathology and epigenetic age acceleration in different human tissues

HIV and Surgery for Degenerative Spine Disease: A Systematic Review

HIV, pathology and epigenetic age acceleration in different human tissues

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