Radical prostatectomy for locally advanced and high-risk prostate cancer: A systematic review of the literature

Delporte, G.; Hénon, François; Ploussard, Guillaume; Briganti, Alberto; Rizk, J.; Rozet, François; Touijer, Karim; Ouzzane, A.

doi:10.1016/j.purol.2018.08.007

Cited by 11 publications

(8 citation statements)

References 48 publications

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“…In our study, in the highrisk group, no patients had recurrence, possibly due to the sample size; nevertheless, we cannot underestimate the effect of patient selection before surgery in the institution, specifically in their risk classification. It was observed that the average age was 65.3 ± 5.91 years, similar to the reported in other studies (63-68 years) [16][17][18] . The main comorbidities were also evaluated, being type 2 diabetes mellitus (15.74%) and arterial hypertension (29.63%) the most frequent; considering that the metabolic syndrome is associated in different studies to increasing risk of prostate cancer 19 .…”

Section: Discussionsupporting

confidence: 89%

Tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación de riesgo de D'amico, en un hospital terciario de referencia: estudio de asociación

Vargas

Sánchez-López

Badillo-Santoyo

et al. 2021

CIRU

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Objective: The objective of the study was to determine the recurrence rate of localized prostate cancer after radical prostatectomy according to the D'Amico classification. Methods: This was a observational and 5-year comparative retrospective cohort study. Data were obtained from clinical records of patients with localized prostate cancer who underwent radical prostatectomy and the recurrence rate of the disease was evaluated. It was analyzed with descriptive and comparative statistical tests, p<0.05 was considered significant. Results: One hundred and eight patients were analyzed, and the average age was 65.3 years. About D'Amico's risk classification, 33.33% low risk, 55.56% intermediate risk, and 11.11% high risk. The prostatespecific antigen (PSA) recurrence rate was 14.81%. Low-risk patients had recurrence of 13.89%, intermediate risk 18.33%, and high risk had no recurrence. Regarding surgical pieces, 25.93% presented adverse characteristics. The post-operative Gleason scale shows an increase of 44.44% in low risk, 26.67% in intermediate risk, and 41.67% in high risk. Conclusions: Radical prostatectomy offers adequate control of localized prostate cancer. The PSA recurrence rate was lower than other international reports. Likewise, the biochemical recurrence of low, intermediate, and high risk was similar to the global trend.

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Section: Discussionsupporting

confidence: 89%

Tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación de riesgo de D'amico, en un hospital terciario de referencia: estudio de asociación

Vargas

Sánchez-López

Badillo-Santoyo

et al. 2021

CIRU

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“…The most probably explanation is the strong correlation between post-RP RAD and DSS Changes. With recent years' increased use of RP in patients with high risk tumors [1,2,28], one has to expect a rising number of men who will be referred to post-RP RAD. Our findings should improve patient councelling before decision of post-RP RAD.…”

Section: Clinical Relevancementioning

confidence: 99%

Prostatectomy with or without post-operative radiotherapy: long-term adverse effects and quality of life

Monsen

Fosså

Dahl

et al. 2020

Scandinavian Journal of Urology

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“…They found BCRFS of 62.7% and 66.2% after a median follow up of 84 and 74 months respectively. A recent systemic review by Delporte G et al described outcome of RP in HRPC in 42 studies and reported 5 year OS of 55.2 to 98.6%, 5 year BCRFS of 40 to 94% and 5 year CSS of 89.8 to 100%[21]. Our slightly low survival rates are may be attributed to the more number of high grade and high stage tumors in study patients.…”

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confidence: 59%

Short Term Outcomes in Indian Patients with High Risk Prostate Cancer after Laparoscopic Radical Prostatectomy- Data from a Single Institute

Patel¹,

Shah²

2020

ann urol oncol

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Background Management of high risk prostate cancer (HRPC) is in evolving stage. Effectiveness of the various treatment strategies is being explored. We examined the short term efficacy of laparoscopic radical prostatectomy (LRP) in treatment of patients with HRPC. Methods Retrospective observational study had 140 HRPC patients of Indian origin, based on D’Amico classification system. Baseline workup was completed. Perioperative parameters and pathological findings were recorded. Multivariate analysis was performed to find predictive factors of pathological stage and PSM. 5 year biochemical recurrence free survival (BCRFS), cancer specific survival (CSS) and overall survival (OS) were calculated. Results Mean age and PSA were 67.24±7.37 years and 23.29 ng/ml respectively. Three fourth of patients had a biopsy GS ≥8. 53.6% of patients were of clinical stage (CS) ≤T2; while 46.4% were of stage ≥T3. Conversion to open surgery rate was 15%. Mean operative time was 210 minutes; blood loss 230 ml; hospital stay 3 days; catheterization time 14 days; grade II or more complication rate 22.1%; LN positivity 20.0%; PSM rate 25.7%; upstaging 35.7%; down-staging 14.3%; pT2 31.4%; pT3a 26.4%; pT3b 42.2%. GS and CS were predictive of pathological stage and PSM respectively. 89.3% of cases were continent postoperatively. 5 year BCRFS, CSS and OS were 68.3%, 89.2% and 78.7% respectively. Conclusions LRP is feasible and effective initial treatment for HRPC. Perioperative morbidity is acceptable. Accurate staging helps in better planning of the adjuvant therapy. Good short term survival can be achieved with multimodal therapy.

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Radical prostatectomy for locally advanced and high-risk prostate cancer: A systematic review of the literature

Cited by 11 publications

References 48 publications

Tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación de riesgo de D'amico, en un hospital terciario de referencia: estudio de asociación

Tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación de riesgo de D'amico, en un hospital terciario de referencia: estudio de asociación

Prostatectomy with or without post-operative radiotherapy: long-term adverse effects and quality of life

Short Term Outcomes in Indian Patients with High Risk Prostate Cancer after Laparoscopic Radical Prostatectomy- Data from a Single Institute

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