Tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación de riesgo de D'amico, en un hospital terciario de referencia: estudio de asociación

Abstract

Objective: The objective of the study was to determine the recurrence rate of localized prostate cancer after radical prostatectomy according to the D'Amico classification. Methods: This was a observational and 5-year comparative retrospective cohort study. Data were obtained from clinical records of patients with localized prostate cancer who underwent radical prostatectomy and the recurrence rate of the disease was evaluated. It was analyzed with descriptive and comparative statistical tests, p<0.05 was considered significant. Results: One hundred and eight patients were analyzed, and the average age was 65.3 years. About D'Amico's risk classification, 33.33% low risk, 55.56% intermediate risk, and 11.11% high risk. The prostatespecific antigen (PSA) recurrence rate was 14.81%. Low-risk patients had recurrence of 13.89%, intermediate risk 18.33%, and high risk had no recurrence. Regarding surgical pieces, 25.93% presented adverse characteristics. The post-operative Gleason scale shows an increase of 44.44% in low risk, 26.67% in intermediate risk, and 41.67% in high risk. Conclusions: Radical prostatectomy offers adequate control of localized prostate cancer. The PSA recurrence rate was lower than other international reports. Likewise, the biochemical recurrence of low, intermediate, and high risk was similar to the global trend.

Epigenetic-related gene-based prognostic model construction and validation in prostate adenocarcinoma

“…For localized PCa, the conventional approach involves radical prostatectomy. Nevertheless, a substantial subset of patients with PCa, approximately 25–30 %, who undergo radical prostatectomy experience progression to advanced disease stages characterized by increased recurrence rates and an unfavorable prognosis within a decade [ 4 ]. This underscores the pressing need for a comprehensive understanding of the intricate etiological mechanisms governing the initiation and progression of PCa.…”