Radical polymerization of <i>N</i>‐vinylcaprolactam in homogeneous solution. II

Solomon, O. F.; Vasilescu, Dan Sorin; Tărărescu, V.

doi:10.1002/app.1969.070130101

Cited by 19 publications

(4 citation statements)

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“…Preparation of poly(ethylene glycol)-b-poly(Nvinylcaprolactam) (PEG-b-PNVCL) block copolymers N-Vinylcaprolactam (NVCL) is an unconjugated monomer that can be polymerized only radically. 47 Until now, only a few studies have been reported on the living radical polymerization of NVCL using cobalt complexes 48,49 and xanthates. 38,50 In the rst strategy named "cobalt-mediated radical polymerization (CMRP)", [51][52][53] NVCL polymerization was controlled by using Co(acac) 2 , a commercially cheap reagent.…”

Section: Resultsmentioning

confidence: 99%

Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

et al. 2014

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5Poly(ethylene glycol)-b-poly(N-vinylcaprolactam) (PEG-b-PNVCL) copolymers are prepared from a PEG macro-chain transfer agent in DMF at 65 °C via reversible addition-fragmentation chain transfer (RAFT) polymerization. Well-defined PEG114-b-PNVCL237 copolymer with a could point temperature of 39 °C is used for the formation of a thermo-responsive polymer corona on the surface of gold nanorods 10 (GNRs) via a "grafting-to" approach. Thermo-responsiveness and thermo-dependent optical properties of the as-obtained GNR@PEG-b-PNVCL nanoparticles are studied with dynamic light scattering and UV/vis spectroscopy techniques. Near infrared (NIR)-induced heating of GNR@PEG-b-PNVCL is also explored in aqueous suspension under NIR laser irradiation (802 nm, up to 250 mW). The potential of these GNR@PEG-b-PNVCL nanoparticles to be used as smart drug delivery systems (DDS) is then 15 studied. A hydrophilic drug model, Rhodamine® B, is used to assess the guest loading capacity, and triggered release behaviours are then evaluated under conventional external heating or internal heating induced by remote NIR irradiation. Cytotoxicity evaluation of the GNR@PEG-b-PNVCL against fibroblast-like L929 cell line is carried out via the MTS assay, in order to confirm the improved biocompatibility of the GNRs after polymer coating. These thermo-responsive GNR@PEG-b-PNVCL 20 nanoparticles are promising DDS that combine the chemotherapeutic and phototherapeutic functions. 115

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Section: Resultsmentioning

confidence: 99%

Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

et al. 2014

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“…NVCL belongs to the family of un‐conjugated monomers and can be polymerized until high molar mass by a conventional radical polymerization process by using AIBN for instance as the free radical initiator in the bulk at 65 °C . However, this process leads to highly polydispersed polymer and attractive structures such as block copolymers are not accessible.…”

Section: Synthesis Of Well‐defined Pnvcl‐based (Co)polymers By Contromentioning

confidence: 99%

Poly(N‐vinylcaprolactam): A Thermoresponsive Macromolecule with Promising Future in Biomedical Field

Liu

Debuigne

Detrembleur

et al. 2014

Adv Healthcare Materials

128

125

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Poly(N-vinylcaprolactam) (PNVCL) is a thermoresponsive and biocompatible polymer that raises an increasing interest in the biomedical area, especially in drug delivery systems (DDS) that include micelles, hydrogels, and hybrid particles. The thermoresponsiveness of PNVCL, used alone or in combination with other stimuli- responsive polymers or particles (pH, magnetic field, or chemicals), is often key in the loading and/or release process in these DDS. The renewed focus on this polymer, which is known for decades, is to a large extent due to recent progress in synthetic strategies. Especially, the advent of efficient controlled radical polymerization (CRP) methods for NVCL monomer gives now access to unprecedented well-defined NVCL-based copolymers with unique properties. This Review article addresses up-to-date synthetic aspects, biological features, and biomedical applications of the latest NVCL-containing systems.

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“…In this work, Solomon et al16 studied the kinetic of the bulk polymerization of N ‐vinylcaprolactam (NVCL). In 1969, Solomon et al17 studied the kinetic of the polymerization of NVCL in toluene. However, nowadays, the interest in the thermo‐responsive behavior of PNVCL is increasing.…”

Section: Introductionmentioning

confidence: 99%

Solution polymerization of N‐vinylcaprolactam in 1,4‐dioxane. Kinetic dependence on temperature, monomer, and initiator concentrations

Medeiros

Barboza

Ré

et al. 2010

J of Applied Polymer Sci

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The kinetics of the solution free radical polymerization of N-vinylcaprolactam, in 1,4-dioxane and under various polymerization conditions was studied. Azobisisobutyronitrile and 3-mercaptopropionic acid were used as initiator and as chain transfer agent (CTA), respectively. The influence of monomer and initiator concentrations and polymerization temperature on the rate of polymerizations (R p ) was investigated. In general, high conversions were obtained. The order with respect to initiator was consistent with the classical kinetic rate equation, while the order with respect to the monomer was greater than unity. The overall activation energy of 53.6 kJ mol À1 was obtained in the temperature range 60-80 C. The decreasing of the absolute molecular weights when increasing the CTA concentration was confirmed by GPC/ SEC/LALS analyses. It was confirmed by UV-visible analyses the effect of molecular weights on the lower critical solution temperature of the polymers. It was also verified that the addition of the CTA influenced the kinetic of the polymerizations.

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Radical polymerization of N‐vinylcaprolactam in homogeneous solution. II

Cited by 19 publications

References 1 publication

Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

Poly(N‐vinylcaprolactam): A Thermoresponsive Macromolecule with Promising Future in Biomedical Field

Solution polymerization of N‐vinylcaprolactam in 1,4‐dioxane. Kinetic dependence on temperature, monomer, and initiator concentrations

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