Radical pleurectomy/decortication and intraoperative radiotherapy followed by conformal radiation with or without chemotherapy for malignant pleural mesothelioma

Lee, Terry T.; Everett, Darcie L.; Shu, Hui; Jahan, Thierry; Roach, Mack; Speight, Joycelyn L.; Cameron, Robert B.; Phillips, Theodore L.; Chan, Albert; Jablons, David M.

doi:10.1067/mtc.2002.125817

Cited by 95 publications

(29 citation statements)

References 22 publications

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“…Asbestos exposure was recorded in 13 papers 7,8,13,16,17,21,22,24,25,27,[31][32][33] and was positive in 64% of patients (682/1061 patients) with a range of 17-95%. The rate in some reports is given for all mesothelioma patients, not just those operated.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of lung-sparing extirpative surgery for pleural mesothelioma

et al. 2011

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SummaryObjectives There is a resurgence of interest in lung-sparing extirpative surgery for malignant pleural mesothelioma with recent reports of better survival and fewer adverse consequences than with extrapleural pneumonectomy. However, these operations are not well-characterized and to offer evidence-based clinical recommendations and to plan future trials a summary of what is already known is required.Design A formal literature search was performed and all recovered titles were sequentially sifted by title, abstract and full-text reading according to prespecified criteria. Papers were selected if they contained data relevant to the area of enquiry. Quantitative synthesis and textual analysis, appropriate to the material, were performed.Setting Follow-up studies of patients undergoing surgery for malignant pleural mesothelioma in specialist thoracic or cardiothoracic units.Participants Among the operated patients described in these papers, a total of 1270 patients had undergone lung-sparing surgery for mesothelioma.Results There were no randomized trials or other forms of controlled studies. From 464 titles, 26 papers contained sufficient data on 1270 patients to be included in the systematic review. Operative descriptions for all series were extracted and tabulated and variation was found in the nature of surgery within and between series, and the degree of detail with which it was described. There was more operative detail in recent papers. All available numerical data were extracted, tabulated and summarized using quantitative methods. The average survival at 1, 2, 3, 4 and 5 years was 51%, 26%, 16%, 11% and 9%, respectively. There were no data on patients' performance status, symptomatic change, or other patient reported outcomes.

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Section: Resultsmentioning

confidence: 99%

“…In 14 reports 8,12,13,17,22,24,26 the breakdown of operated patients by histology is provided ( Figure 3). The dominance of epithelioid type is evident.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of lung-sparing extirpative surgery for pleural mesothelioma

et al. 2011

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“…Administering adjuvant RT after P/D, with the lung still in situ, may cause severe toxicity and high risk of radiation pneumonitis (26). Grades 3-4 pneumonitis have been reported in up to 20% of patients (24).…”

Section: P/dmentioning

confidence: 99%

Pleurectomy/decortication versus extrapleural pneumonectomy: a critical choice

et al. 2018

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“…In a small, highly selected series of 32 patients, there was a 6.3% mortality rate and an 18-month median survival; most treatment failures were locoregional. 21,22 Cytoreductive surgery with intraoperative photodynamic therapy (PDT) has been studied in several centers. The use of intraoperative intrapleural chemotherapy has been reported in several small series including hyperthermic (40-41 o C) perfusion, most with cisplatin.…”

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confidence: 99%

Malignant Pleural Mesothelioma: A Comprehensive Review

et al. 2006

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Radical pleurectomy/decortication and intraoperative radiotherapy followed by conformal radiation with or without chemotherapy for malignant pleural mesothelioma

Abstract: Radical pleurectomy/decortication with aggressive radiotherapy with or without chemotherapy might offer an alternative treatment option to those who cannot tolerate extrapleural pneumonectomy.

Cited by 95 publications

References 22 publications

A systematic review of lung-sparing extirpative surgery for pleural mesothelioma

A systematic review of lung-sparing extirpative surgery for pleural mesothelioma

Pleurectomy/decortication versus extrapleural pneumonectomy: a critical choice

Malignant Pleural Mesothelioma: A Comprehensive Review

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