Radical Neck Dissection for Thorium Dioxide Granuloma: Case Report

Chalat, Ned I.; Zane, Alan I.

doi:10.1001/archotol.1966.00760020612026

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…Thirteen cases of radiation-induced malignant tumours have been reported in these granulomata (Hara et al, 1972;Hasson et al, 1975, da Motta et al, 1979. Radical neck dissection for removal of the Thorotrast granuloma has therefore been advocated (Chalat and Zane 1966;Lung et al, 1978). Another paper reported severe difficulties and complications with postoperative arterial ruptures in one patient, and arterial thrombosis with hemiparesis in another (Chobaut et al, 1980).…”

Section: Discussionmentioning

confidence: 99%

Late effects of perivascular injection of Thorotrast in the neck

1984

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Two cases of late sequelae of accidental perivascular injection of Thorotrast (thorium dioxide) during carotid arteriography are presented. The complaints of the patients and the clinical findings are due to topical granulomatous and fibrous reactions with compression of the carotid artery and cranial nerves, and influence upon larynx and trachea. For future decades it will still be necessary to be aware of this possible cause of neck tumours with oto-laryngeal and neurological symptoms.

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Section: Discussionmentioning

confidence: 99%

Late effects of perivascular injection of Thorotrast in the neck

1984

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“…IO,16,17 Over the years, epidemiologic studies have correlated Thorotrast exposure to a greatly increased incidence of liver cancer, hepatoma, leukemia, and liver cirrhosis.Ui'f Andersson et a}11 noted a 50% excess mortality in patients exposed to Thorotrast, mainly due to liver disease. 3,6,15,16 France prohibited the use ofThorotrast in 1935,10,15 afterresearchers there discovered that the contrast agent induced sarcomas in laboratory animals.…”

Section: Case Reportmentioning

confidence: 99%

Cervical Thorotrast Granuloma: A Review of the Literature and a New Treatment Modality

Ung¹,

Lazor²,

Montgomery³

1998

Ann Otol Rhinol Laryngol

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Extravasation of thorium dioxide after transcervical carotid angiography has resulted in persistent open draining neck wounds. These difficult problems have remained a challenge for the treating head and neck surgeon. Neck dissection has been the mainstay of treatment in the past; however, this has been fraught with complications. The application of doxycycline sclerosis is described in the successful resolution of a large thorotrast granulomatous neck wound. A review of the literature and the management options of Thorotrast granulomas are discussed.

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Long‐term survival with thorotrast cervical granuloma

Lung¹,

Harding²,

Herceg³

et al. 1978

Journal of Surgical Oncology

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Thorium dioxide, a radioactive contrast material, was commonly used for cerebral angiography prior to recognition of its radiation hazard. Extravasation of the material into the extravascular tissue in the neck results in granuloma formation, thorotrastoma, long-term morbidity, and an increased incidence of benign and malignant tumors. We report our experience with the management of 2 patients who underwent cerebral angiography with thorotrast more than 25 years ago. Aggressive surgical excision of involved tissue is warranted to ameliorate symptoms and diminish the risk of malignancy.

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Radical Neck Dissection for Thorium Dioxide Granuloma: Case Report

Cited by 9 publications

References 15 publications

Late effects of perivascular injection of Thorotrast in the neck

Late effects of perivascular injection of Thorotrast in the neck

Cervical Thorotrast Granuloma: A Review of the Literature and a New Treatment Modality

Long‐term survival with thorotrast cervical granuloma

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