Long‐term survival with thorotrast cervical granuloma

Abstract

Thorium dioxide, a radioactive contrast material, was commonly used for cerebral angiography prior to recognition of its radiation hazard. Extravasation of the material into the extravascular tissue in the neck results in granuloma formation, thorotrastoma, long-term morbidity, and an increased incidence of benign and malignant tumors. We report our experience with the management of 2 patients who underwent cerebral angiography with thorotrast more than 25 years ago. Aggressive surgical excision of involved tissue is warranted to ameliorate symptoms and diminish the risk of malignancy.

Thorotrast Granuloma of the Neck

“…Thorotrast has as its main active constituent thorium dioxide, the radioactivity of which has a physical half-life of 1.39 x 1010 years and a biological half-life of 400 years (Lung et al 1978). It is taken up by the cells of the reticuloendothelial system following administration, and no significant excretion occurs.…”