Radiation treatment of acute inflammation in mice

Abstract

Ionizing radiation, even at low doses, functionally modulates inflammatory cells. Our findings indicate possible mechanisms as to how low-dose radiation may exert anti-inflammatory effects and provide the first evidence that heat shock proteins may be involved in this response.

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

“…In activated and inflammatory macrophages for example, an involvement of the iNOS pathway in the response to LD-RT has been described [102]. Irradiated, inflammatory macrophages exhibit a reduced oxidative burst capacity, resulting in a reduced level of inflammatory nitric oxygen (NO) and free reactive oxygen species (ROS) [103,104]. Moreover, altered cytokine expression of activated macrophages after exposure to LD-RT seems to be a key player in the induction of the anti-inflammatory reactions.…”

Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

“…Moreover, radiation, even at low-doses, functionally modulates inflammatory cells, and the mechanism by which low-dose radiation exerts anti-inflammatory effects may involve heat shock proteins [20]. However, there have been no reports on anti-inflammatory effects of radon inhalation in mice.…”

A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves’ orbitopathy

“…Target cells seem to be mononuclear cells, possibly lymphocytes, which are considered effectors of GO, though resident endothelial cells and activated macrophages are affected as well [25]. Heat shock proteins and the induction of nitric oxide synthase in activated macrophages may also be involved in the anti-inflammatory response to radiation [26]. Impairment of motility in GO is caused mainly by glycosaminoglycane deposition between extraocular muscle fibres.…”