Radiation Therapy of Cutaneous Carcinomas: Radiation Techniques and Dose Schedules

Goldschmidt, Herbert

doi:10.1007/978-1-4613-9041-1_6

Cited by 13 publications

(12 citation statements)

References 51 publications

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“…Published cumulative 5 year recurrence rates for subgroups agree with our results. 23 Our findings confirm results of earlier studies: higher cure rates of BCCs compared with SCCs, 8,9,15,18,36 of previously untreated tumors compared with previously treated and recurrent ones, 8,9,15,23,[34][35][36] and of smaller malignancies or those with a lower T-class or stage. y Tumor thickness (half-value depth) and field size had a different influence on recurrences and ulcerations after treatment of BCCs compared with SCCs.…”

Section: Discussionsupporting

confidence: 94%

“…Some authors use fractionation schedules with definite total doses; others vary the total dose. 8,9,32,34 The tumor regression under treatment 15 or the development of erythema 23 is taken into account. Some drawbacks of our approach have to be admitted; we cannot monitor the complete degeneration of the tumor under treatment with exact precision.…”

Section: Discussionmentioning

confidence: 99%

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Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Schulte¹,

Lippold²,

Auras³

et al. 2005

Journal of the American Academy of Dermatology

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Schulte¹,

Lippold²,

Auras³

et al. 2005

Journal of the American Academy of Dermatology

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“…The replication time of BCCs is estimated to be approximately 9 days, and weekly doses are time‐dose appropriate. Such schedules have been used widely in Europe for treatment of BCC ≤ 2‐cm‐diameter 12 . After Marrón‐Gasca et al 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Radiation penetration (“quality”) was selected with a half‐value depth (HVD) corresponding to the tumor depth (estimated by biopsy or palpation when histologic depth was not reported). A margin of at least 5 mm of clinically unaffected skin around the tumor was irradiated 12,13 . The field size was delineated by a lead cut‐out of thickness appropriate to the radiation quality.…”

Section: Methodsmentioning

confidence: 99%

Office‐based radiation therapy for cutaneous carcinoma: Evaluation of 710 treatments

et al. 2007

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Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based elective radiation therapy for cutaneous carcinoma. A retrospective study of 604 basal cell carcinomas (BCCs) and 106 squamous cell carcinomas (SCCs) irradiated between 1971-96 was performed. The percentage of patients who developed tumor recurrence during the follow-up period was calculated using Kaplan-Meier survival curves. Cox's proportional model was used to assess the prognostic factors that might have influenced the recurrences. The recurrence rates for BCC and SCC were 11.5 and 16.5 per 1000 patient-years, respectively. The 5-year cure rates were 94.4% for BCC and 92.7% for SCC, and the 15-year cure rates were 84.8% and 78.6%, respectively. Tumor location on the nasolabial fold (OR 4.4; 95% IC, 1.3-14.7) and tumor size > or = 10 mm (OR 2.14; 95% IC, 1.03-4.45) were independent predictors of BCC recurrence. This study suggested that radiation therapy is an effective treatment for BCC and SCC and should be considered as a first option in many cases.

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“…In the evaluation of the results it is very important to assess that the clinical series include pure forms of MBCCs only, as it is in our series, as the partially sclerosing forms are logically characterized by a greater radiosensitivity . Another important feature is represented by the duration of follow‐up: it has been reported that the mean time to recurrence after RT of BCCs is 20 months and that 86.4% of all recurrences occurs within 3 years from the treatment .…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy of morphea‐type basal cell carcinoma: results in 127 cases

Caccialanza

Piccinno

Çuka

et al. 2014

Acad Dermatol Venereol

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Because of the frequent diagnostic delay and its ill-defined margins, MBCC is difficult to cure. Our results after 5 years from RT (cure rate 81.08%) are more satisfactory respect to the others reported in the literature (69% and 72.3%), but less good than those obtained in other forms of primary malignant neoplasms of the skin (92.43%). Nevertheless,we consider that RT plays an important role in the therapeutic strategy of MBCCs. In fact, it can be applied easily in elderly patients, and in peculiar localization of the disease (eyelid, nose and ear), without being invasive.

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Radiation Therapy of Cutaneous Carcinomas: Radiation Techniques and Dose Schedules

Cited by 13 publications

References 51 publications

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Office‐based radiation therapy for cutaneous carcinoma: Evaluation of 710 treatments

Radiotherapy of morphea‐type basal cell carcinoma: results in 127 cases

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