Radiation therapy in operable breast cancer: Results from the Stockholm trial on adjuvant radiotherapy

Wallgren, Arne; Arner, O; Bergström, Johan; Blomstedt, B; Granberg, Per‐Ola; Räf, Lars; Silfverswäd, Claes; Einhorn, J.

doi:10.1016/0360-3016(86)90060-x

Cited by 96 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous surgical trial showed no difference in survival [35]. Similarly, the Oslo and Stockholm trials did not show an improvement in overall survival in patients that received irradiation of regional nodes [15,36]. By contrast, one retrospective analysis evaluating treatment to the IMNs and three recent randomized trials in axillary node-positive postmastectomy patients revealed a relatively large impact on OS in favor of the patient groups receiving RT, with an improved HR similar to the magnitude of systemic chemotherapy or tamoxifen [3,[20][21][22].…”

Section: Targeting Internal Mammary Nodes By Radiation Therapymentioning

confidence: 99%

Internal Mammary Nodes in Invasive Breast Carcinoma

Grabenbauer

2004

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

Section: Targeting Internal Mammary Nodes By Radiation Therapymentioning

confidence: 99%

Internal Mammary Nodes in Invasive Breast Carcinoma

Grabenbauer

2004

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

“…The Stockholm trial (62,63) This trial was conducted from 1971 to 1976 and included 960 patients in three arms: control, preoperative and post- 6 Includes only clinical node-negative patients. operative radiation therapy.…”

Section: The Oslo Trialsmentioning

confidence: 99%

Adjuvant Radiotherapy in Breast Cancer: The Treatment of Lymph Node Areas

Arriagada

Lê

2000

Acta Oncologica

View full text Add to dashboard Cite

“…This effect has also been suggested by two Scandinavian randomized trials [18][19][20] evaluating locoregional treatment. The same kind of patients benefit in this series from the IMC radiation, i.e., large tumors with high risk of axillary lymph node involvement.…”

Section: Discussionmentioning

confidence: 66%

Radiotherapy Alone in Breast Cancer: Analysis of Tumor Parameters, Tumor and Lymph Node Doses, Lymph Node Control, Distant Metastasis, and Survival Rates—The Experience of the Gustave‐Roussy Institute and the Princess Margaret Hospital

Arriagada

Mouriesse

Sarrazin

et al. 1993

Radation Oncology Invest

View full text Add to dashboard Cite

SUMMARY This retrospective analysis involved 453 breast cancer patients treated by radiotherapy alone at the Princess Margaret Hospital and at the Institut Gustave-Roussy. These patients either had operable tumors, but were unfit for general anesthesia, or had inoperable tumors due to local contraindications to surgery. Results were analyzed according to lymph node response, lymph node recurrence rate, distant metastasis rate, survival rate, tumor size, clinical N category, age, tumor dose, axillary dose, and internal mammary chain irradiation. Multivariate analysis permitted the definition of a risk score for axillary lymph node recurrence (RS,,) according to two independent factors: tumor size and clinical N category. It was shown that the RSLN was a good single composite prognostic factor for lymph node control. Increase in axillary dose gave a similar effect on the axillary lymph node recurrence relative risk for all the RSLN groups. According to the slope of the axillary dose-effect curve, it was deduced that a dose increase of 15 Gy can decrease the relative risk of lymph node recurrence 2-fold. A similar slope was previously described for tumor dose and local control. A risk score for distant metastases ( R s d was calculated according to three independent prognostic factors: tumor size, clinical N category, and age. The RSM was not influenced by the tumor or the axillary dose but by the treatment of the internal mammary chain. Similar results were obtained for the risk score for death (RS,). The present data emphasize the role of the lymph node radiation dose in the lymph node control of locally advanced breast cancer.

show abstract

Radiation therapy in operable breast cancer: Results from the Stockholm trial on adjuvant radiotherapy

Cited by 96 publications

References 6 publications

Internal Mammary Nodes in Invasive Breast Carcinoma

Internal Mammary Nodes in Invasive Breast Carcinoma

Adjuvant Radiotherapy in Breast Cancer: The Treatment of Lymph Node Areas

Radiotherapy Alone in Breast Cancer: Analysis of Tumor Parameters, Tumor and Lymph Node Doses, Lymph Node Control, Distant Metastasis, and Survival Rates—The Experience of the Gustave‐Roussy Institute and the Princess Margaret Hospital

Contact Info

Product

Resources

About