Radiation therapy for vestibular schwannomas

Mulder, Jef J. S.; Kaanders, J.H.A.M.; Overbeeke, J.J. van; Cremers, C.W.R.J.

doi:10.1097/moo.0b013e328357d337

Cited by 16 publications

(8 citation statements)

References 44 publications

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“…In recent years, radiation therapy has become a common alternative to surgical resection of intracranial schwannomas. 16 17 18 19 20 21 Options include either single-fraction SRS or conventional daily low-dose fractionation over approximately five weeks. SRS is a well-tolerated procedure, typically completed during a single session of irradiation and far more convenient for the patient.…”

Section: Discussionmentioning

confidence: 99%

A Rare Finding of Schwannoma of the Vidian Canal: A Case Report

et al. 2015

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Background Schwannomas of the vidian canal are an extremely rare type of intracranial tumor that can have variable clinical presentations including headache, facial pain, facial muscle paralysis, decreased lacrimation, or nasal dryness. We present an atypical case of an incidentally identified asymptomatic vidian canal schwannoma. Case Description A 49-year-old woman with a history of multiple sclerosis presented for routine surveillance magnetic resonance imaging that detected an ovoid mass originating in the vidian canal. Given the unusual location of the lesion, an endoscopic endonasal biopsy was performed and confirmed the diagnosis of a vidian canal schwannoma, for which the patient chose to receive fractionated radiation therapy. Conclusion When a vidian canal tumor is identified, endoscopic endonasal biopsy can be used to confirm the diagnosis before pursuing either surgical or radiotherapy treatment. In particular, fractionated radiation therapy offers a radiobiologically safe means of delivering radiation when there is concern for late radiation-related side effects following treatment completion.

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Section: Discussionmentioning

confidence: 99%

A Rare Finding of Schwannoma of the Vidian Canal: A Case Report

et al. 2015

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“…3 Recent studies undertake a cost-effectiveness analysis comparing these three approaches. 30,31 Using a Markov decision analysis model, the benefit derived from each management strategy in quality-adjusted life years (QALYs) was measured.…”

Section: Comparison Of Radiotherapy With Other Approachesmentioning

confidence: 99%

Radiotherapy for vestibular schwannoma: Review of recent literature results

Apicella

Paolini

Deantonio

et al. 2016

Reports of Practical Oncology & Radiotherapy

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“…27 Stereotactic radiotherapy appears to be effective up to 95% of the cases, even after 15 years of follow up. 28,29 Source of radiation in SR and fractionated SR is either gamma ray photons or a linear accelerator which uses Xray photons derived from high-energy electrons. According to a recent systematic review incidents of malignant transformation or occurrence of a new malignant tumor have been referred after stereotactic radiosurgery.…”

Section: Discussionmentioning

confidence: 99%

Predictive factors of acoustic neuroma growth

Kikidis

Xenellis

Kyrodimos

et al. 2016

Int J Otorhinolaryngol Head Neck Surg

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Background:Since the use of magnetic resonance imaging (MRI) as the gold standard for acoustic neuroma diagnosis, the size of the majority of newly diagnosed acoustic neuromas has decreased. Management strategy is challenging, especially in young patients with small tumors. Therefore, prognostic factors for tumor growth may facilitate physicians to optimize treatment choice.Methods:Patients diagnosed with acoustic neuromas were recruited in this study. Gender, age, side, presence of hearing loss, tinnitus, vertigo, unsteadiness, other symptoms, hearing level in the affected ear and tumor growth at the first follow up MRI were recorded. Two primary endpoints were set: overall acoustic neuroma (AN) growth and growth correlated to treatment plan change (clinically significant growth). Multivariate and survival analysis were conducted to this end. Results:85 patients were finally included in the study. The most prevalent presenting symptoms were hearing loss (76%), tinnitus (56%) and unsteadiness (46%). The tumour grew in size in less than 50% of the cases during the observation period. Clinically significant growth was observed in 27% of the cases. Mean initial diameter was 10.41mm and mean final follow-up diameter (diameter at the end of the observation period) 12.73 mm. Following binary logistic regression analysis, tumour growth during the initial follow up visit was found to be correlated in a statistically significant level to overall tumour growth (p-value 0.023). Regarding clinically significant growth, three factors were found to be statistically significant: growth at the initial visit (p-value 0.02), initial diameter (p-value 0.045) and existence of unsteadiness at diagnosis (p-value 0.02).Conclusions:Acoustic neuroma overall growth is not identical to clinically significant growth. Growth at first visit is a significant prognostic factor and intervention potential should be considered under this perspective.

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Radiation therapy for vestibular schwannomas

Cited by 16 publications

References 44 publications

A Rare Finding of Schwannoma of the Vidian Canal: A Case Report

A Rare Finding of Schwannoma of the Vidian Canal: A Case Report

Radiotherapy for vestibular schwannoma: Review of recent literature results

Predictive factors of acoustic neuroma growth

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