Radiation therapy for nasopharyngeal carcinoma. Retrospective review of 105 patients based on a survey of Kansai Cancer Therapist Group

Abstract

One hundred five patients with nasopharyngeal carcinoma were treated with radiation therapy combined with or without chemotherapy at 16 of the participating institutes in Kansai Cancer Therapist Group, Japan, from January 1978 to December 1980. The study comprised 77 males and 28 females; their ages ranged from 15 to 80 years (mean, 53 years). Five-year survival rates according to stage were as follows: Stage I, 100%; Stage II, 67%; Stage III, 44%; and Stage IV, 34%. As far as Stage IV disease was concerned, the radiation therapy only group showed significantly poorer prognosis than the combined radiation and chemotherapy group (P less than 0.05). Concerning the N stage and treatment method, the radiation therapy only group showed a higher metastatic rate than the chemotherapy combined group (35% versus 14%, P less than 0.05).

Radiation-Induced Temporal Lobe Injury for Nasopharyngeal Carcinoma: A Comparison of Intensity-Modulated Radiotherapy and Conventional Two-Dimensional Radiotherapy

“…Fractional dose is generally considered to be highly significant in terms of TLI development, and our study presents a relatively higher incidence of TLI than has been reported in previous studies that used comparable fractional size [9], [17]–[18]. This inconsistency is probably due to the different diagnostic modalities utilized in different studies.…”

Genome-Wide Analyses of Radioresistance-Associated miRNA Expression Profile in Nasopharyngeal Carcinoma Using Next Generation Deep Sequencing

“…The incidence of NPC is up to 20 per 100 000 persons and radiotherapy is the most common treatment strategy [2]. Despite recent advances in radiation techniques, rapidly emerging evidence indicates that NPC recurrence and metastasis still account for the majority of NPC-related deaths, even after aggressive therapy [3]. Radioresistance accounts for the majority of treatment failures and leads to relapse and metastasis in NPC patients after radiotherapy.…”

Neuropsychological Function in Patients with Nasopharyngeal Carcinoma after Radiotherapy

“…Evidence regarding radionecrosis of neural tissue in the central nervous system owing to damage to both nerve fibers and vasculature has been well documented (Lee, 1991;Martins, Johnston, Henry, Stoffel, & Di Chiro, 1977;Schultheiss, Stephens, & Maor, 1988) . More specifically, the main sites of lesions include the inferomedial temporal area, cervical spinal cord, pituitary gland, and cranial nerve (Chatani et al, 1986;Lee, Ng, & Ho, 1988;Woo, Lam, Yu, Lee, & Huang,1987).…”