Neuropsychological Function in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Hua, Mau‐Sun; Chen, Sien-Tsong; Tang, Lok‐Ming; Leung, Wai-Man

doi:10.1076/jcen.20.5.684.1131

Cited by 33 publications

(35 citation statements)

References 10 publications

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“…Six studies [8][9][10][11][12][13] evaluated the neurocognitive effects of potential radiation-induced brain injury. The study samples included only patients with either nasopharyngeal or paranasal sinus tumors, in which treatment entailed incidental radiation to normal brain tissue and thus the potential for direct radiation damage.…”

Section: Introductionmentioning

confidence: 99%

“…The studies also have other methodological limitations. Five studies [8,9,[11][12][13] used cross-sectional designs with only posttreatment neurocognitive assessments with varied control groups and inconsistent posttreatment assessment time points ranging from 7 days to 30 years.…”

Section: Introductionmentioning

confidence: 99%

“…Data on neurocognitive functioning in patients with head and neck cancer (HNC) are primarily limited to eight small studies [8][9][10][11][12][13][14][15]. Six studies [8][9][10][11][12][13] evaluated the neurocognitive effects of potential radiation-induced brain injury.…”

Section: Introductionmentioning

confidence: 99%

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Neurocognitive function in patients with head and neck cancer undergoing primary or adjuvant chemoradiation treatment

Bond

Dietrich

Gilbert

et al. 2016

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Purpose Cancer and cancer therapy-related neurocognitive changes negatively affect quality of life, yet few studies have examined neurocognitive changes in patients with head and neck cancer. The purpose of this study was to evaluate neurocognitive performance in patients with head and neck cancer at baseline before starting treatment and 3 months after treatment completion to assess treatment-associated changes in performance. Methods Patients with head and neck cancer who were to receive primary or adjuvant chemoradiation (N = 55) underwent neuropsychological testing before and 3 months posttreatment. Changes in neurocognitive performance were assessed using a practice effect adjusted Reliable Change Index.Results At baseline, 38 % of patients exhibited global neurocognitive impairment. Posttreatment, 21.8 % demonstrated declines in neurocognitive performance in at least one domain. Declines in domain-specific performance ranged from 1.8 to 12.7 % with the greatest decline in language, specifically verb retrieval. Domain-specific improvements ranged from 0 to 7.3 %. Conclusions Patients had a high prevalence of baseline neurocognitive impairment. While neurocognitive performance posttreatment remained unchanged in the majority, almost 13 % suffered declines in language. Small percentages of patients exhibited improvements in their performance. Long-term effects and risk factors for neurocognitive decline in this population should be studied on a larger scale.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neurocognitive function in patients with head and neck cancer undergoing primary or adjuvant chemoradiation treatment

Bond

Dietrich

Gilbert

et al. 2016

Support Care Cancer

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“…Tang et al [35] reported that NPC patients with radiation-induced brain injury (RI) exhibited negative emotions, impaired cognitive function and quality of life (QOL). The accumulated studies showed that the radiation-induced functional impairments included the disorder of short-term memory [36], personality changes [37] and motor abilities [38], a marked anterograde memory impairment for verbal material [39], neuropsychological impairments in recent memory, immediate and delayed verbal recall, and immediate visual recall [40].…”

Section: Resultsmentioning

confidence: 99%

Identify the radiotherapy-induced abnormal changes in the patients with nasopharyngeal carcinoma

Wang

Zhao

Zhang³

et al. 2017

ADMET DMPK

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<p class="ADMETabstracttext">Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma, which often causes inevitable brain injury in the process of treatment. The majority of patients has no abnormal signal or density change of the conventional magnetic resonance imaging (MRI) and computed tomography (CT) examination in the long-term follow-up after radiation therapy. However, when there is a visible CT and conventional MR imaging changes, the damage often has been severe and lack of effective treatments, seriously influencing the prognosis of patients. Therefore, the present study aimed to investigate the abnormal changes in nasopharyngeal carcinoma (NPC) patients after RT. In the present study, we exploited the machine learning framework which contained two parts: feature extraction and classification to automatically detect the brain injury. Our results showed that the method could effectively identify the abnormal regions reduced by radiotherapy. The highest classification accuracy was 82.5 % in the abnormal brain regions. The parahippocampal gyrus was the highest accuracy region, which suggested that the parahippocampal gyrus could be most sensitive to radiotherapy and involved in the pathogenesis of radiotherapy-induced brain injury in NPC patients.</p>

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“…Those changed regions, located in the memory and emotional network, might related with the clinical manifestations of the memory of patients with NPC after radiotherapy. Studies showed that the radiation-induced functional impairments included the disorder of short-term memory [26], personality changes [36], a marked anterograde memory impairment for verbal material [37], and neuropsychological impairments in recent memory, immediate and delayed verbal recall and immediate visual recall [38].…”

Section: Hub Regions In Post-rt-related Networkmentioning

confidence: 99%

Radiation-Induced Changes in Structural Network in Patients with Nasopharyngeal Carcinoma

Tian¹

2017

AJCEM

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Radiation therapy (RT) is the standard radical treatment for nasopharyngeal carcinoma (NPC), and has produced excellent effects in terms of survival rate [1,2]. However, one of the serious complications gave rise by the RT is brain injury. Previous studies have found that RT could cause brain structural abnormalities on gray matter and white matter. Nevertheless, the RT effects on the network level should be further investigated. Herein, we explored changes on the structural network for patients with NPC induced by RT. The structural magnetic resonance data (sMRI) were used to investigate the structural network in 20 NPC patients after and before radiotherapy. After constructing the structural network, we examined the radiation-induced changes in topology properties of small world network using graph theoretical analysis. Our results found that both the before and after radiotherapy groups showed small world properties. Compared with the before radiotherapy (pre-RT) group, the after radiotherapy (post-RT) group had lower global and local efficiency, longer shortest path length, and less clustering coefficient. In addition, the hub regions in the post-RT group were significantly different from the pre-RT group. Our findings exhibited the architecture of network topology and information transfer efficiency became poor in post-RT group. We speculated radiation therapy might induce the differences. The results can provide a new perspective to explore and diagnose radiation-induced brain injury and evaluate the effect of radiotherapy.

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Neuropsychological Function in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Cited by 33 publications

References 10 publications

Neurocognitive function in patients with head and neck cancer undergoing primary or adjuvant chemoradiation treatment

Neurocognitive function in patients with head and neck cancer undergoing primary or adjuvant chemoradiation treatment

Identify the radiotherapy-induced abnormal changes in the patients with nasopharyngeal carcinoma

Radiation-Induced Changes in Structural Network in Patients with Nasopharyngeal Carcinoma

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