Radiation therapy for early glottic cancer (tlnomo): II. Prospective randomized study concerning radiation field

Teshima, Teruki; Chatani, Masashi; Inoue, Toshihiko

doi:10.1016/0360-3016(90)90275-o

Cited by 48 publications

(19 citation statements)

References 5 publications

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“…This is probably due to the tumor itself, or because RT produces a geometric asymmetry and, henceforth, a loss of elasticity of the vocal folds. Some authors incriminate the use of continuing smoking [36] or the field size [64]. In our multidisciplinary tumor board, we explain the advantages and disadvantages of the various treatment modalities to the patients, who ultimately decide for themselves.…”

Section: Resultsmentioning

confidence: 99%

“…Numerous reports regarding the treatment of early glottic cancer have evaluated a number of prognostic factors, i.e., tumor volume and stage [20,28,37], tumor kinetics including p53 status [3,13,48], histological differentiation, intrinsic radiosensitivity [28], smoking habits and hypoxia [9], pretreatment hemoglobin level [14,59,69], dose per fraction [70], total dose [62], overall treatment time [4,10,18,27,52,53,58], field size [64], beam energy [16,19], radiation technique [61], and anterior commissure involvement [41,51]. These factors were not always reported to have a prognostic influence by all authors [17,30,46,66,67].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

et al. 2004

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

et al. 2004

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“…The radiation field of about 5 Â 5 cm 2 for the 4 MV Liniac X-ray is used for T1 glottic cancer. However, no difference in the local control rates has been reported between 5 Â 5 cm 2 and 6 Â 6 cm 2 [7]. The epiglottis and the lower border of the cricoid cartilage are the upper and lower borders, respectively, of the radiation field.…”

Section: Discussionmentioning

confidence: 98%

Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone

Furusaka¹,

Matuda²,

Saito³

et al. 2012

Acta Oto-Laryngologica

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In 57 patients, we observed CR in 33 patients, partial response (PR) in 20 patients, no change (NC) in 4 patients, and progression disease (PD) in none of the patients. The response rate was 93.0% and the CR rate was 57.9%. The survival rates (Kaplan-Meier method) were: 5-year survival rate of 88.5% and 10-year survival rate of 73.5%. The larynx preservation rates (Kaplan-Meier method) were: 5-year larynx preservation rate of 60.4% and 10-year larynx preservation rate of 50.1%. The main side effect of grade 3 or more was only stomatitis in four patients, all of which were reversible changes (CTCAT v3.0 JCOG/JSCO). Salvage operation was required in 34 (59.6%) of 57 patients, 10 patients underwent partial laryngectomy, total laryngectomy was performed in 3 of the 10 patients following the partial laryngectomy, and 27 patients (47.4%) underwent total laryngectomy. The surgical specimens were serially sectioned at a thickness of 4 μm and examined histopathologically and compared to the macroscopic findings at surgery. The safe margin for partial laryngectomy was considered grossly to be 5 mm from the edge of the tumor.

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“…Numerous reports regarding the treatment of early stage glottic cancer have evaluated some prognostic factors, i.e., tumor volume, stage, tumor kinetics including p53 status, histological differentiation, intrinsic radiosensitivity, continued smoking during and after RT and hypoxia, low hemoglobin levels, poorly differentiated tumors, dose per fraction, total dose, overall treatment time, field size, beam energy, radiation technique, and anterior commissure involvement [3,[16][17][18][19][20][21][22][23][24][25]. These factors were not constantly presented to have a prognostic influence by all authors.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Ekici¹,

Temelli²,

Eraslan³

et al. 2016

Med-Science

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Our aim was to determine the treatment outcomes and the prognostic factors affecting local control in early stage glottic carcinoma (ESGC) treated with definitive radiotherapy (RT). Between April 2003 and May 2015, 76 patients with ESGC were treated at Inonu University Hospital. There were 58 patients with T1a, 7 T1b and 11 with T2 tumors. Twenty-two patients were treated with conformal radiotherapy, 31 patients were treated with conventional RT and 23 patients were treated with intensity modulated radiotherapy as initial treatment. During a median follow-up of 51 months (range 6-136), 11 patients had failures. Five year overall survival rates were 73.7% in T1 and 81.8% T2. Local control rate was 85.5% in our patients. Patients who were over 61 years had significantly lower local control (p = 0.042). One patient treatment was interrupted because of grade 3 edema. One patient had grade 3 dermatitis, 2 patients grade 3 mucositis and 4 patients grade 3 edema, respectively. Our results suggest that curative radiotherapy is an effective treatment modality in ESGC without increasing toxicity. Age proved to be the only independent prognostic factor affecting local control after primary radiotherapy according to the results of this study.

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Radiation therapy for early glottic cancer (tlnomo): II. Prospective randomized study concerning radiation field

Cited by 48 publications

References 5 publications

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

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