Radiation Synthesis of Poly(Starch/Acrylic acid) pH Sensitive Hydrogel for Rutin Controlled Release

Ghaffar, A. M. Abdel; Radwan, Rasha R.; Ali, Hussein E.

doi:10.1016/j.ijbiomac.2016.07.079

Cited by 31 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This behavior is attributed to the presence of an acidic carboxylic group which ionizes closer to neutral and at alkaline pH to give anionic pendant groups which are responsible for the swelling. Histopathological testing of these hydrogels showed release of rutin in negligible quantity before the colon and controlled delivery in the colon [133].…”

Section: Applications Of Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

View full text Add to dashboard Cite

Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pK a and pK b values on the ionization, consequent swelling, and targeted drug release are also highlighted.

show abstract

Section: Applications Of Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The pH-sensitive hydrogels were prepared by grafting acrylic acid onto the chains of carboxymethyl chitosan loaded with insulin. Ghaffar et al prepared pH-sensitive acrylic acid-grafted starch hydrogels to study the controlled release of rutin in the colon [ 30 ]. Kim and Oh developed crosslinked glycidyl methacrylate dextran and poly(acrylic acid) pH-sensitive hydrogels for colon specific drug delivery [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

et al. 2020

View full text Add to dashboard Cite

The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.

show abstract

“…The development of pH-sensitive HG is also considered a good approach for colon-targeted delivery of drugs, as in the case of ulcerative colitis, a chronic inflammatory disorder of the GI tract. A RU-loaded poly(starch/acrylic acid) HG showed a strong pH-dependent release behavior, thus offering a maximum release as pH increased from pH 6.8 (small intestine pH) up to pH 7.7 (colon pH), and is endowed with a good protective effect after oral administration on mucosal injury in a dextran sulphate sodium-induced rat model of colitis [ 55 ].…”

Section: Potential Biomedical Applications Of (Poly)phenols Loadedmentioning

confidence: 99%

“…Therefore, HGs may react positively to these changes and enable the sustained and controlled release of their bioactive components accordingly. In this regard, Abdel Ghaffar A.M. and co-workers improved the performance of starch-based HGs by grafting the polymer onto acrylic acid via the direct gamma radiation technique [ 55 ]. This synthetic method offers some advantages, including the sterility of the product, the non-use of chemicals, the simultaneous cross-links and HG formation, and the ease of process control.…”

Section: Hydrogels Projected For Oral and Systemic Administrationmentioning

confidence: 99%

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

et al. 2020

View full text Add to dashboard Cite

This review deals with hydrogels as soft and biocompatible vehicles for the delivery of plant-derived (poly)phenols, compounds with low general toxicity and an extraordinary and partially unexplored wide range of biological properties, whose use presents some major issues due to their poor bioavailability and water solubility. Hydrogels are composed of polymeric networks which are able to absorb large amounts of water or biological fluids while retaining their three-dimensional structure. Apart from this primary swelling capacity, hydrogels may be easily tailored in their properties according to the chemical structure of the polymeric component in order to obtain smart delivery systems that can be responsive to various internal/external stimuli. The functionalization of the polymeric component of hydrogels may also be widely exploited to facilitate the incorporation of bioactive compounds with different physicochemical properties into the system. Several prototype hydrogel systems have been designed for effective polyphenol delivery and potential employment in the treatment of human diseases. Therefore, the inherent features of hydrogels have been the focus of considerable research efforts over the past few decades. Herein, we review the most recent advances in (poly)phenol-loaded hydrogels by analyzing them primarily from the therapeutic perspective and highlighting the innovative aspects in terms of design and chemistry.

show abstract

Radiation Synthesis of Poly(Starch/Acrylic acid) pH Sensitive Hydrogel for Rutin Controlled Release

Cited by 31 publications

References 25 publications

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

Contact Info

Product

Resources

About