Radiation synthesis and characterization of stimuli-sensitive chitosan–polyvinyl pyrrolidone hydrogels

γ-irradiated chitosan-polyvinyl pyrrolidone hydrogels as pH-sensitive protein delivery system

“…The hydrogels were synthesized as reported earlier (Dergunov et al, 2005). In brief, CS was dissolved in distilled water.…”

“…Moreover, by using a radiation technique, the hydrophilicity as well as porosity can be controlled at a low temperature, and it is a very convenient method for preparing a drug delivery system. Thus, looking to the significant consequences of protein adsorption on biomaterial surface, we are reporting in the present study results on the adsorption and release of bovine serum albumin (BSA) onto the surface of a novel hydrogels prepared with CS and PVP via radiation technique (Dergunov et al, 2005).…”

“…In a previous study (Dergunov et al, 2005), we prepared hydrogels composed of CS and PVP and investigated their properties such as pH-dependent swelling and interaction with surfactant. In this study, we prepared the model drug-loaded pHsensitive CSPVP hydrogels and investigated the effect of pH on protein adsorption and release.…”

Influence of Poly (Ethylene Glycol) on the Characteristics of γ Radiation-Crosslinked Poly (Vinyl Pyrrolidone)-Low Molecular Weight Chitosan Network Hydrogels

“…The networks are developed by crosslinking reaction of polymers induced by chemical or physical agents. Conventionally, crosslink networks of hydrogels are prepared by chemical reaction with the presence of crosslinker such as gluteraldehyde and epoxides (Dergunov et al 2005;Yang et al 2010). Due the toxicity issue, the chemical crosslinker are unfavourable in biomaterials preparation (Pollock & Healy 2010).…”

Hydrogels from Chitosan and a Novel Copolymer Poly(<i>N</i>-Vinyl-2-Pyrrolidone-<i>Co</i>-Acrolein)

“…Hydrogels are three-dimensional hydrophilic polymer networks capable of swelling in water or biological fluids and retaining a great amount of fluid in the swollen state without dissolution of their structure [11,12]. They can be obtained through chemical and physical processes [13].…”