Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling

Skvortsova, Ira; Debbage, Paul; Kumar, Vinod; Skvortsov, Sergej

doi:10.1016/j.semcancer.2015.09.009

Cited by 130 publications

(90 citation statements)

References 65 publications

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“…Interestingly, EA-induced spheres showed high proliferative activity in comparison with OA-induced spheres, which suggests that EA-induced CSCs might be proliferating CSCs but not dormant CSCs [35] . EA also provided drug resistance to 5-FU in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 95%

Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

et al. 2016

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The effects of trans-fatty acids (TFAs) on cardiovascular disorders have been extensively studied, and the effect of TFAs on cancers has recently been recognized. This study examined the effects of elaidic acid (EA), a TFA, on colorectal cancer (CRC) progression. We demonstrated that EA enhanced the growth, survival, and invasion of the CRC cell lines, CT26, and HT29. Tumor growth and metastasis in the lung, liver, and peritoneum were significantly more enhanced in CRC cells treated with EA than those treated with the cis form of EA, oleic acid (OA), or vehicle. Spheres of CRC cells were formed at more pronounced numbers in EA-treated cells than in OA-treated cells. Compared to OA, EA treatment also induced expression of the stemness factors, nucleostemin, CD133, and Oct4. Moreover, spheres of EA-treated CRC cells were larger and more proliferative than spheres of OA-treated cells. Oral intake of EA also enhanced liver metastasis and CD133 expression of CRC cells in a dose-dependent manner. EA intake also increased resistance to 5-fluorouracil. Inhibition of Wnt and ERK1/2 abrogated EA-induced enhancement of metastasis. Our findings demonstrate that EA might provide prominent metastatic potential to CRC cells, which shows important implications for the treatment of CRC.

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Section: Discussionmentioning

confidence: 95%

Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

et al. 2016

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“…Slow-growth state. The effectiveness of radiation and chemotherapy is in part dependent on cell proliferation rate, which underlies the increased sensitivity of cancer cells over normal cells (132,133). Ergo, GBM cells in a state of slow growth could play an important role in recurrence as suggested by human and mouse studies (20, 55, 134, 135).…”

Section: Molecular Pathways Implicated In Therapeutic Resistance Of Rmentioning

confidence: 99%

“…Tumor cells, including GBM, overexpress PD-L1 (153). Blockade of the PD-1 pathway in mice also promotes killing of GSCs by NK cells division (132,133). Slow-growing tumor cells are important targets to prevent chemo-and radioresistance (20,55,132,133,(159)(160)(161).…”

Section: Molecular Pathways Implicated In Therapeutic Resistance Of Rmentioning

confidence: 99%

“…Blockade of the PD-1 pathway in mice also promotes killing of GSCs by NK cells division (132,133). Slow-growing tumor cells are important targets to prevent chemo-and radioresistance (20,55,132,133,(159)(160)(161). However, in the majority of molecularly targeted therapies, the targets of interest were selected based on highly expressed molecules found on a large fraction of tumor cells, such as the tyrosine kinase receptors, and their downstream signaling effectors (162)(163)(164).…”

Section: Molecular Pathways Implicated In Therapeutic Resistance Of Rmentioning

confidence: 99%

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Overcoming therapeutic resistance in glioblastoma: the way forward

Osuka¹,

Meir²

2017

Journal of Clinical Investigation

388

311

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“…In fact, it is estimated that about one-half to two-thirds of cancer patients receive this type of therapy [1]. Although it has many advantages including local tumor control, a large proportion of patients experience radioresistance and cancer recurrence [2].…”

Section: Introductionmentioning

confidence: 99%

The Role of Canonical Wnt Signaling in Regulating Radioresistance

Zhao

Tao

et al. 2018

Cell Physiol Biochem

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Radioresistance is a major obstacle in radiotherapy for cancer, and strategies are needed to overcome this problem. Currently, radiotherapy combined with targeted therapy such as inhibitors of phosphoinosotide 3-kinase/Akt and epidermal growth factor receptor signaling have become the focus of studies on radiosensitization. Apart from these two signaling pathways, which promote radioresistance, deregulation of Wnt signaling is also associated with the radioresistance of multiple cancers. Wnts, as important messengers in the tumor microenvironment, are involved in cancer progression mainly via canonical Wnt signaling. Their role in promoting DNA damage repair and inhibiting apoptosis facilitates cancer resistance to radiation. Thus, it seems reasonable to target Wnt signaling as a method for overcoming radioresistance. Many small-molecule inhibitors that target the Wnt signaling pathway have been identified and shown to promote radiosensitization. Therefore, a Wnt signaling inhibitor may help to overcome radioresistance in cancer therapy.

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Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling

Cited by 130 publications

References 65 publications

Elaidic Acid, a <b><i>Trans</i></b>-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

Elaidic Acid, a <b><i>Trans</i></b>-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells

Overcoming therapeutic resistance in glioblastoma: the way forward

The Role of Canonical Wnt Signaling in Regulating Radioresistance

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