Radiation recall dermatitis induced by mogamulizumab

Abstract

The role of histopathological characteristics in distinguishing amalgam-associated oral lichenoid reactions and oral lichen planus.

Radiation recall dermatitis triggered by inactivated COVID‐19 vaccine

“…South Dakota). 3,4 Restrictive tanning legislation was previously found to be most effective at modulating public interest in indoor tanning. 5 States with more stringent restrictions also demonstrated greater encouragement of social distancing and had more expansive public information campaigns, which may also have contributed to the lower interest in indoor tanning.The study has several limitations.…”

“…2 RRD is mainly triggered by cytotoxic chemotherapeutics, but there are also several reports with antibiotics, monoclonal antibodies and immunomodulators. [1][2][3] We report a patient with melanoma who developed RRD following the first dose of COVID-19 vaccine.…”

“…[2][3][4] A paradoxical upregulation of the mitogen-activated protein kinase (MAPK) pathway together with a reactive enhanced expression of c-KIT have been hypothesized, with subsequent induction of melanocytic proliferation. 3 To our knowledge, this is the first case of melanoma development associated with darkening and eruptive naevi in a patient undergoing cetuximab therapy. It is also reasonable to suggest a paradoxical activation of the MAPK pathway related to the EGFR blockage in our patient.…”

“…Both categories of EGFR inhibitors have been associated with similar skin AEs, except for the onset of darkening and eruptive naevi on the trunk and extremities associated with erlotinib, which were described in three previous reports. [2][3][4] A paradoxical upregulation of the mitogen-activated protein kinase (MAPK) pathway together with a reactive enhanced expression of c-KIT have been hypothesized, with subsequent induction of melanocytic proliferation. 3 To our knowledge, this is the first case of melanoma development associated with darkening and eruptive naevi in a patient undergoing cetuximab therapy.…”

“Radiation Recall Phenomenon” with Novel Cytotoxic Agents: An Emerging Trend in the Last Decade

“…A 65-year-old male with relapsed ATLL underwent RT (50.4 Gy) to the superior mediastinum. 39 Three weeks after the completion of RT, weekly mogamulizumab was started and after three courses, he developed a geometric area of RRD.…”