Radiation levels in cyclotron-radiochemistry facility measured by a novel comprehensive computerized monitoring system

Mishani, Eyal; Lifshits, N.; Osavistky, A.; Kaufman, J. V. R.; Ankry, N.; Tal, Nikolay; Chisin, Roland

doi:10.1016/s0168-9002(98)01407-7

Cited by 7 publications

(2 citation statements)

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“…FLUORODEOXYGLUCOSE [ 18 FDG] is the most commonly used radiopharmaceutical in Positron Emission Tomography (PET) (Mishani et al 1999). 18 F is produced in cyclotrons through a number of possible nuclear reactions before being converted into 18 FDG.…”

Section: Introductionmentioning

confidence: 99%

“…While whole-body radiation doses received by staff in nuclear medicine and PET clinics (Zanzonico et al 2008;Covens et al 2007;Sharma et al 2006;Eschner et al 2000;Ostertag et al 1991), cyclotron production facilities (Major 2009;Mishani et al 1999) and finger/extremity measurements within routine dispensing and handling of radiopharmaceuticals (Vanhavere et al 2008;Wrzesień et al 2008;Ginjaume et al 2007;Tandon et al 2007;Pant et al 2006;Saether et al 2005;Martin and Whitby 2003;Dhanse et al 2000) have been previously reported, the published data on finger/ extremity radiation doses received by staff performing routine quality control of 18 FDG is limited. Therefore, the aim of this study was to determine the finger/extremity doses received during this process and determine whether or not staff would need to be designated as classified radiation workers as a result of the work undertaken (Ionizing Radiation Regulations 2000).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Staff Finger Doses During Quality Control of FDG Production

Ferguson¹,

McGrath²,

O'Hara³

et al. 2011

Health Physics

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The European Pharmacopoeia and Good Manufacturing Practice define a number of quality control tests that must be performed prior to the release of FDG. The aim of this study is to determine the finger dose received while performing these tests. The finger dose received by four staff members was measured using Unfors NED monitors placed at the tip of the index finger of both hands during routine quality control. A total of 18 readings were obtained for the dispensing of the quality control samples, bubble point test, thin layer chromatography, gas chromatography, endotoxin test, Kryptofix test, multi-channel analyzer test, pH and high performance liquid chromatography. The average total dose for the completion of all tests was 1,508 Sv for the left hand and 846 Sv for the right hand. As a result of the bubble point test, 54% and 43% of the total dose is received for the left and right hand, respectively. The pH test, high performance liquid chromatography and dispensing of the QC sample also contribute significantly to the total dose. Staff may need to be defined as classified radiation workers as a result of the finger dose received during routine quality control. Automation of the bubble point test and dispensing should be considered during the planning and design of any new cyclotron production facility. Health Phys. 100(5):523-529; 2011

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Section: Introductionmentioning

confidence: 99%