Radiation-induced preparation of core/shell gold/albumin nanoparticles

Flores, Constanza; Achilli, Estefanía Edith; Grasselli, Mariano

doi:10.1016/j.radphyschem.2017.02.030

Cited by 10 publications

(4 citation statements)

References 18 publications

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“…Radiation-based synthesis for NPs construction can be carried out through degradation, crosslinking, graft copolymerization, and also radiation-induced reduction of metallic ions. This technique can be used for generating (i) radiation-crosslinked nanogels from synthetic/biopolymers [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ], (ii) conjugated NPs from size-controlled polymer templates through radiation [ 85 , 86 ], (iii) NPs from self-assembly of radiation-induced grafted copolymers [ 87 , 88 ], and (iv) AuNPs-hybrid NPs from radiation-induced reduction [ 89 , 90 , 91 , 92 , 93 , 94 ]. These are summarized in Table 3 .…”

Section: Radiation-based Synthesis Of Nanoparticlesmentioning

confidence: 99%

“…Recently ready-to-use templates for radioactive 198 AuNPs, using biopolymers incorporating tumour-targeted peptides, have been successfully developed for use as nanomedicine agents in molecular imaging and therapy [ 91 ]. It has been proven that core-shell AuNPs can be efficiently synthesized in albumin protein solution under irradiation [ 92 , 93 , 95 ].…”

Section: Radiation-based Synthesis Of Nanoparticlesmentioning

confidence: 99%

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IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

et al. 2022

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The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists comprised of the development of nanoparticles (NPs) based on metals, polymers, and gels, and their conjugation/encapsulation or decoration with various tumor avid ligands such as peptides, folates, and small molecule phytochemicals. The research and development efforts also comprised of developing optimum radiolabeling methods of various nano vectors using diagnostic and therapeutic radionuclides including Tc-99m, Ga-68, Lu-177 and Au-198. Concerted efforts of teams of scientists within this CRP has resulted in the development of various protocols and guidelines on delivery systems of nanoradiopharmaceuticals, training of numerous graduate students/post-doctoral fellows and publications in peer reviewed journals while establishing numerous productive scientific networks in various participating member states. Some of the innovative nanoconstructs were chosen for further preclinical applications—all aimed at ultimate clinical translation for treating human cancer patients. This review article summarizes outcomes of this major international scientific endeavor.

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Section: Radiation-based Synthesis Of Nanoparticlesmentioning

confidence: 99%

Section: Radiation-based Synthesis Of Nanoparticlesmentioning

confidence: 99%

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

et al. 2022

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“…Theranostic NPs, that combined organic nanoparticles (including liposomes, micelles/polymeric micelles, lipid nanoparticles, protein based nanoparticles) with co-delivery of drugs, and inorganic NPs (e.g., QDs, gold nanoparticles, and silica nanoparticles) as imaging contrast, have been developed and the major part of the results displayed a higher effectiveness than the commercial references [397,398,399,400,401,402,403,404,405]. The explosion of NPs for clinical imaging and therapy has not occurred yet.…”

Section: Theranosticsmentioning

confidence: 99%

Targeted Theranostic Nanoparticles for Brain Tumor Treatment

et al. 2018

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The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-growing process and invasive nature, which make difficult the complete removal of the cancer infiltrated tissues. Additionally, GB heterogeneity within and between patients demands a patient-focused method of treatment. Thus, the implementation of nanotechnology is an attractive approach considering all anatomic issues of GB, since it will potentially improve brain drug distribution, due to the interaction between the blood–brain barrier and nanoparticles (NPs). In recent years, theranostic techniques have also been proposed and regarded as promising. NPs are advantageous for this application, due to their respective size, easy surface modification and versatility to integrate multiple functional components in one system. The design of nanoparticles focused on therapeutic and diagnostic applications has increased exponentially for the treatment of cancer. This dual approach helps to understand the location of the tumor tissue, the biodistribution of nanoparticles, the progress and efficacy of the treatment, and is highly useful for personalized medicine-based therapeutic interventions. To improve theranostic approaches, different active strategies can be used to modulate the surface of the nanotheranostic particle, including surface markers, proteins, drugs or genes, and take advantage of the characteristics of the microenvironment using stimuli responsive triggers. This review focuses on the different strategies to improve the GB treatment, describing some cell surface markers and their ligands, and reports some strategies, and their efficacy, used in the current research.

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“…For many years the effort of many researchers into NP targeting has been hampered by the ‘corona effect’ masking the original chemical or biological functionalities of the recognition molecule [ 17 ]. Recently, we described novel protein/gold biohybrid NPs containing a chemically stable multilayer of albumin coating [ 18 , 19 ]. This procedure was based on radiation-induced protein crosslinking [ 20 ] and further decoration with specific peptides for cell targeting [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Two-Step Preparation of Protein-Decorated Biohybrid Quantum Dot Nanoparticles for Cellular Uptake

Traverso,

Fragale,

Viale

et al. 2023

Pharmaceutics

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Decoration of nanoparticles with specific molecules such as antibodies, peptides, and proteins that preserve their biological properties is essential for the recognition and internalization of their specific target cells. Inefficient preparation of such decorated nanoparticles leads to nonspecific interactions diverting them from their desired target. We report a simple two-step procedure for the preparation of biohybrid nanoparticles containing a core of hydrophobic quantum dots coated with a multilayer of human serum albumin. These nanoparticles were prepared by ultra-sonication, crosslinked using glutaraldehyde, and decorated with proteins such as human serum albumin or human transferrin in their native conformations. These nanoparticles were homogeneous in size (20–30 nm), retained the fluorescent properties of quantum dots, and did not show a “corona effect” in the presence of serum. The uptake of transferrin-decorated quantum dot nanoparticles was observed in A549 lung cancer and SH-SY5Y neuroblastoma cells but not in non-cancerous 16HB14o- or retinoic acid dopaminergic neurons differentiated SH-SY5Y cells. Furthermore, digitoxin-loaded transferrin-decorated nanoparticles decreased the number of A549 cells without effect on 16HB14o-. Finally, we analyzed the in vivo uptake of these biohybrids by murine retinal cells, demonstrating their capacity to selectively target and deliver into specific cell types with excellent traceability.

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Radiation-induced preparation of core/shell gold/albumin nanoparticles

Cited by 10 publications

References 18 publications

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

Targeted Theranostic Nanoparticles for Brain Tumor Treatment

Two-Step Preparation of Protein-Decorated Biohybrid Quantum Dot Nanoparticles for Cellular Uptake

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