Radiation induced polymerization and crosslinking behavior of N-hydroxy methyl acrylamide in aqueous solutions

Acharya, Anjali; Mohan, Hari; Sabharwal, S.

doi:10.1016/s0969-806x(02)00271-2

Cited by 17 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Environmentally sensitive gels can be obtained by the addition of special monomers. 4,5 Watersoluble polymers owe their solubility properties to the presence of functional groups (mainly OH, COOH, NH 2 ) that can be used for the formation of hydrogels. Covalent linkages between polymer chains can be established by the reaction of functional groups with complementary reactivity, such as an amine-carboxylic acid or an isocynate-OH/NH 2 reaction.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

2007

View full text Add to dashboard Cite

The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as solution) was compared with the mixture of PVA and gelatin of the same composition. The mechanical properties of the hydrogels were characterized by tensile tests. Swelling behavior and hemocompatibility of the membrane were also evaluated. The diffusion coefficient of salicylic acid (SA), when the receptor compartment contained Ringer's solution, through the membrane was determined. SA was used as a model drug. FTIR spectra of the membranes indicated complete esterification of the free carboxylic groups of gelatin. XRD studies indicated that the crystallinity of the membranes was mainly due to gelatin. The comparison of viscosity indicated an increase in segment density within the molecular coil. The membrane had sufficient strength and water-holding capacity. Hemocompatibility suggested that the hydrogel could be tried as wound dressing and as an implantable drug delivery system. The diffusion coefficient of SA through the membrane was found to be 1.32 × 10 −5 cm 2 /s. The experimental results indicated that the hydrogel could be tried for various biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

2007

View full text Add to dashboard Cite

show abstract

“…The hydrogel characteristics, among which the swelling, can be modulated by the amount of crosslinker. Moreover stimuli sensitive materials such as pH-sensitive gels and temperature-sensitive gels can be obtained by the addition of special monomers [7,8].…”

Section: Introductionmentioning

confidence: 99%

Water uptake in chemically crosslinked poly(acrylamide-co-crotonic acid) hydrogels

2005

View full text Add to dashboard Cite

“…The strength and swelling of hydrogels can be adjusted or controlled by the quantity of cross-linking agent. Environmentally responsive gels can also be fabricated upon the addition of specific type of monomers [17][18][19]. Figure 1 indicates the graphical representation of different crosslinking methods.…”

Section: Open Accessmentioning

confidence: 99%

Biocompatible hydrogels for the controlled delivery of anti-hypertensive agent: development, characterization and in vitro evaluation

Nawaz

Khan

Farooq

et al. 2018

Designed Monomers and Polymers

View full text Add to dashboard Cite

The aim of the present exploration was to develop novel pH-sensitive cross-linked Gelatin/Polyvinyl pyrrolidone hydrogels using different ratios of both the polymers and to investigate the effect of polymers and degree of crosslinking on dynamic, equilibrium swelling and invitro release pattern of the model drug (captopril). Grafting polymerization technique was used for the preparation of these hydrogels using glutaraldehyde as crosslinking agent. These polymeric materials were then used as model systems to envisage various important characterizations like FTIR (Fourier transform infrared spectroscopy), XRD (X-ray diffraction) and scanning electron microscopy (SEM). Phosphate buffers of pH 1.2, 6.5 and 7.5 were used for swelling and invitro drug release profile investigation. Different parameters like swelling analysis, porosity, sol-gel analysis, average molecular weight between crosslinks (Mc), solvent interaction parameter (χ), volume fraction of polymer (V 2,s) and diffusion coefficient that affects the drug release behavior were also determined. Higher swelling and release was observed at lower pH values. FTIR spectra showed interaction between gelatin and polyvinyl pyrrolidone and successful formation of cross-linked structure. Pulsatile drug release study showed the controlled delivery of model drug. The release of drug occurred through non-fickian diffusion or anomalous mechanism. Aforementioned characterizations reveal successful formation of copolymer. pH sensitive swelling ability and drug release behavior suggest that the rate of polymer chain relaxation and the rate of drug diffusion from these hydrogels are comparable which also predicts their possible use for site specific captopril delivery.

show abstract

Radiation induced polymerization and crosslinking behavior of N-hydroxy methyl acrylamide in aqueous solutions

Cited by 17 publications

References 15 publications

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

Water uptake in chemically crosslinked poly(acrylamide-co-crotonic acid) hydrogels

Biocompatible hydrogels for the controlled delivery of anti-hypertensive agent: development, characterization and in vitro evaluation

Contact Info

Product

Resources

About