Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

Abstract

The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as solution) was compared with the mixture of PVA and gelatin of the same composition. The mechanical properties of the hydrogels were characterized by tensile tests. Swelling behavior and hemocompatibility of the membrane were also evaluated. The diffusion coefficient of salicylic acid (SA), when the receptor compartment contained Ringer's solution, through the membrane was determined. SA was used as a model drug. FTIR spectra of the membranes indicated complete esterification of the free carboxylic groups of gelatin. XRD studies indicated that the crystallinity of the membranes was mainly due to gelatin. The comparison of viscosity indicated an increase in segment density within the molecular coil. The membrane had sufficient strength and water-holding capacity. Hemocompatibility suggested that the hydrogel could be tried as wound dressing and as an implantable drug delivery system. The diffusion coefficient of SA through the membrane was found to be 1.32 × 10 −5 cm 2 /s. The experimental results indicated that the hydrogel could be tried for various biomedical applications.

Boosting Oxygen Delignification of Poplar Kraft Pulp by Xylanase Pretreatment

“…The peak at 2900 cm -1 belonged to C-H stretching. The peaks at 1125 and 1200 cm -1 were attributed to C-O stretching and O-H in-plane bending coupled vibrations (Kondo 1997;Pal et al 2007). As expected, the xylanase-assisted oxygen delignification did not cause significant changes to the chemical structure of the cellulose of the pulps.…”

Polymeric Hydrogels: Characterization and Biomedical Applications

“…In general, the higher the % age swelling, the higher is the amount of water imbibed and the higher is the diffusion rate of the solute, though other factors, viz., micro-architecture of the polymer chain, may also play an important role. Experimentally, % age swelling can be determined by weight difference method and is expressed by the following equation [18]:…”

“…The double cell diffusion apparatus can be either vertical or horizontal (Figs 1 and 2). At any time t, the concentration values in the two chambers can be used to calculate the diffusion coefficient, D, of the drug in the hydrogel from the following equation [18,20]:…”

Development of non-woven nanofibers of egg albumen-poly (vinyl alcohol) blends: influence of solution properties on morphology of nanofibers

“…Thus, PVA is being used in food, biomedical, cosmetic and pharmaceutical applications. [25][26][27] In addition to these properties, PVA has the ability to form nanofibers. 28,29 In this communication, we report the electrospinning of PVA-EA blends and their characterization.…”