Polymeric Hydrogels: Characterization and Biomedical Applications

Pal, Kunal; Banthia, A. K.; Majumdar, Dipak K.

doi:10.1163/156855509x436030

Cited by 297 publications

(198 citation statements)

References 60 publications

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“…Alternatively, grafting of a hydrophobic polymer onto a hydrophilic polymer also opens a strategy to design mechanically strong polymer matrices. Hydrophilic polymer improves hydrogel swelling capacity, whereas the hydrophobic copolymer imparts required mechanical strength [2]. In copolymer systems, the swelling process can be controlled by the introduction of the appropriate amount of a second monomer with hydrophobic character.…”

Section: Introductionmentioning

confidence: 99%

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Jain

Bajpai

2012

Designed Monomers and Polymers

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Polyethylene glycol (PEG)-based semi-IPNs have been widely used as hydrogel matrices in tissue engineering applications because of their inherent hydrophilicity and biocompatibility. Today, synthetic scaffolds are being widely used in tissue engineering and allied applications because they offer the ability to precisely control the mechanical properties, morphology, and blood compatibility of the materials. In this regard, an attempt has been made to develop scaffolds membranes by judiciously combining PEG, polyvinyl alcohol, and polymethyl methacrylate. The so prepared hydrogel membranes were undertaken for structural, morphological, and thermal characterization using FTIR, scanning electron microscope (SEM), and DSC techniques, respectively. The hydrogel films were investigated for water sorption capacity under various experimental conditions such as changing chemical composition of the membrane, different pH, and temperature of the swelling media and varying simulated biological fluids. The hydrogel membranes were also studied for their catholicity and in vitro blood compatibility property by following several tests such as blood clot formation, percent haemolysis, and protein adsorption.

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Section: Introductionmentioning

confidence: 99%

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Jain

Bajpai

2012

Designed Monomers and Polymers

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“…The represents the total area under the diffraction curve between 2θ = 10 ° − 80 °. level of crystallinity is of tremendous significance in the polymer industry and can be dictated by XRD [24].…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

Synthesis of Wound-Healing Keratin Hydrogels Using Chicken Feathers Proteins and Its Properties

Priyaah

Gupta

Sharma

2017

Int J Pharm Pharm Sci

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Objective: A novel cross-linked keratin hydrogel was prepared by integrating keratin from chicken feather into an aloe-vera, Chitosan and honey based dressing formulation separately.Methods: Keratin fibres extracted from chicken feathers are eco-friendly, non-abrasive, biodegradable, insoluble in organic solvents and having good mechanical properties, hydrophobic behaviour, low density and finally cheap. Keratin based hydrogels were prepared with five types of ingredients and studied for their wound healing properties. The analysis of keratin-based hydrogel was done by Fourier Transform Infra-red Spectroscopy (FTIR) and X-ray diffraction (XRD) analysis.Results: Keratinocytes containing keratin travel from the wound border to initiate the process of healing. The characteristics of keratin-based hydrogel derived from chicken feather made it an effective wound care therapeutic product. X-ray diffraction (XRD) analysis showed the crystallinity index in between 30-50% of the hydrogen. Conclusion:The test for swelling and solubility were carried out on the hydrogen to determine the solid content and water absorbance capacity. Overall, this product is safe to use as an effective wound healing product with appropriate properties.

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“…This is the case of the anchorage ring of cornea prosthesis, for which a thin biointegrable biostable material is required [1][2][3][4][5][6][7][8][9]. In other cases a patch of a biostable material for cell carrier can be pressed on the damaged tissue to induce a paracrinic effect by a continuous growth factor delivery, this could find application in wound healing, and cornea or skin regeneration [10][11][12][13][14][15][16][17]. Pore architecture of these scaffolds must be quite particular to fit simultaneously requirements of high porosity (as large as possible), pore interconnectivity, and 3 pore size adequate for cell invasion, small thickness and mechanical resistance.…”

Section: Introductionmentioning

confidence: 99%

Macroporous thin membranes for cell transplant in regenerative medicine

et al. 2015

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ElsevierAntolinos Turpín, CM.; Morales Román, RM.; Ródenas Rochina, J.; Gómez Ribelles, JL.; Gómez-Tejedor, JA. (2015). Macroporous thin membranes for cell transplant in regenerative medicine. Biomaterials. 67:254-263. doi:10.1016/j.biomaterials.2015.07.032. Biomaterials 67 (2015 ABSTRACTThe aim of this paper is to present a method to produce macroporous thin membranes made of poly (ethyl acrylate-co-hydroxyethyl acrylate) copolymer network with varying cross-linking density for cell transplantation and prosthesis fabrication. The manufacture process is based on template techniques and anisotropic pore collapse. Pore collapse was produced by swelling the membrane in acetone and subsequently drying and changing the solvent by water to produce 100 microns thick porous membranes. These very thin membranes are porous enough to hold cells to be transplanted to the organism or to be colonized by ingrowth from neighboring tissues in the organism, and they present sufficient tearing stress to be sutured with surgical thread. The obtained pore morphology was observed by Scanning Electron Microscope, and confocal laser microscopy. Mechanical properties were characterized by stress-strain experiments in tension and tearing strength measurements. Morphology and mechanical properties were related to the different initial thickness of the scaffold and the cross-linking density of the polymer network.Seeding efficiency and proliferation of mesenchymal stem cells inside the pore structure were determined at 2 hours, 1, 7, 14 and 21 days from seeding.

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Polymeric Hydrogels: Characterization and Biomedical Applications

Cited by 297 publications

References 60 publications

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Synthesis of Wound-Healing Keratin Hydrogels Using Chicken Feathers Proteins and Its Properties

Macroporous thin membranes for cell transplant in regenerative medicine

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