Radiation-induced nondisjunction in oocytes of aged mice

Uchida, Irene A.; Freeman, Cole

doi:10.1038/265186a0

Cited by 38 publications

(12 citation statements)

References 9 publications

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“…The preponderance of hypoploid oocytes is probably due to chromosome loss during oocyte fixation. Other investigators have also observed an excess of hypoploid oocytes (Rohroorn, 1972;Hansmann, 1974;Uchida and Lee, 1974). The frequency of oocytes with 19 chromosomes is significantly higher in the middle maternal-age group.…”

Section: Chromosomal Analysis Of Oocytesmentioning

confidence: 73%

Nondisjunction in aging female mice

Martin¹,

Dill²,

Miller³

1976

Cytogenet Genome Res

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Oocytes from CBA mice varying in age from 2 to 11 months were cultured to the metaphase II stage of meiosis and the chromosomes analyzed. The oocytes from three maternal age groups were compared with respect to the mean number of oocytes obtained per mouse, the frequency of maturation to metaphase II, and the frequency of numerical chromosome abnormalities. Both the mean number of oocytes obtained per mouse and the frequency of maturation decreased markedly with maternal age. The frequency of chromosome abnormalities in the oocytes increased with maternal age from the young to the middle-aged mice but dropped off in the oldest maternal age group. No hyperploid (n + 1) oocytes were observed in the young or old group of mice, but 5.2 % hyperploidy occurred in the middle-aged group. It is suggested that the lack of hyperploid oocytes in the old CBA females might be due to a threshold effect in which oocytes that are damaged by the number of univalents present at metaphase I become atretic and do not progress to metaphase II. The frequency of diploid (2n) oocytes was 1.7 % and was not maternal-age dependent.

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Section: Chromosomal Analysis Of Oocytesmentioning

confidence: 73%

Nondisjunction in aging female mice

Martin¹,

Dill²,

Miller³

1976

Cytogenet Genome Res

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“…However, the rate of moderate preparations available for the oocyte chromosome studies was generally low (McGaughey and Chang 1969 ;Ingalls and Yamamoto 1972 ;Uchida and Freeman 1977). Compared with the methods used by the previous workers, the improved method by Kamiguchi et al (1976) was rather superior and effective for the study of these subjects.…”

Section: Resultsmentioning

confidence: 93%

Notes on cytogenetic effects of irradiation on the oocytes at meiotic stages in the chinese hamster.

Sonta

1981

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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“…The age effect on the spontaneous incidence of hyperdiploid Fi embryos is only on the borderline of significance or otherwise doubtful (23,44,45). On balance, advancing maternal age does seem to have some influence on spontaneous nondisjunction, but, at least for radiation, appears to produce no differential increase in induced nondisjunction (21,23,46). Some investigators (47) have, in fact, not been able to show any effect of irradiation on trisomy induction in oocytes, even in very old females.…”

Section: Agementioning

confidence: 99%

“…In the male, pachytene has been found slightly sensitive in M II analysis (17); and zygotene, pachytene, and diplotene in M I analysis (20). In the female, irradiation of dictyate oocytes in old mice has been claimed to increase nondisjunctional indicators (21,22). In young adult females, irradiation during dictyate, or in the interval between dictyate and diakinesis, failed to cause increases in ND indicators (23) or caused increases that were restricted to one group (24), or nonsignificant (22,25), or on the borderline of significance (26).…”

Section: Protocolsmentioning

confidence: 99%

Meiotic Nondisjunction in the Mouse: Methodology for Genetic Testing and Comparison with Other Methods

Russell¹

1979

Environmental Health Perspectives

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Since trisomies produce adverse effects relatively late in development or even postnatally, they are an important component of the array of genetic damages that might be caused by environmental agents. Whole-chromosome aneuploidy (as opposed to breakage-derived aneuploidy) might come about secondarily from crossover depression, or could follow damage to the meiotic spindle or to kinetochores. For simplicity, the event -by whichever ofthe mechanisms-is referred to as meiotic nondisjunction (ND) With respect to potential human misery caused, the trisomies that result from nondisjunction may be

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Radiation-induced nondisjunction in oocytes of aged mice

Cited by 38 publications

References 9 publications

Nondisjunction in aging female mice

Nondisjunction in aging female mice

Notes on cytogenetic effects of irradiation on the oocytes at meiotic stages in the chinese hamster.

Meiotic Nondisjunction in the Mouse: Methodology for Genetic Testing and Comparison with Other Methods

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