Radiation-induced gray matter atrophy in patients with nasopharyngeal carcinoma after intensity modulated radiotherapy: a MRI magnetic resonance imaging voxel-based morphometry study

Shi, Lei; Du, Fang; Sun, Zhenliang; Zhang, Lan; Chen, Yuanyuan; Xie, Tieming; Li, Peijing; Huang, Shuang; Dong, Baiqiang; Zhang, Minming

doi:10.21037/qims.2018.10.09

Cited by 28 publications

(20 citation statements)

References 28 publications

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“…Radiotherapy induced brain atrophy has been observed across the whole brain [4][5][6][7], hippocampus [8][9][10][11], amygdala [12] and cerebellum [13]. The findings show consistently that the amount of tissue loss is dose dependent [5,13,14].…”

Section: Introductionmentioning

confidence: 84%

Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy

Gommlich

Raschke

Petr

et al. 2021

Magn Reson Mater Phy

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Objective Brain atrophy has the potential to become a biomarker for severity of radiation-induced side-effects. Particularly brain tumour patients can show great MRI signal changes over time caused by e.g. oedema, tumour progress or necrosis. The goal of this study was to investigate if such changes affect the segmentation accuracy of normal appearing brain and thus influence longitudinal volumetric measurements. Materials and methods T1-weighted MR images of 52 glioblastoma patients with unilateral tumours acquired before and three months after the end of radio(chemo)therapy were analysed. GM and WM volumes in the contralateral hemisphere were compared between segmenting the whole brain (full) and the contralateral hemisphere only (cl) with SPM and FSL. Relative GM and WM volumes were compared using paired t tests and correlated with the corresponding mean dose in GM and WM, respectively. Results Mean GM atrophy was significantly higher for full segmentation compared to cl segmentation when using SPM (mean ± std: ΔVGM,full = − 3.1% ± 3.7%, ΔVGM,cl = − 1.6% ± 2.7%; p < 0.001, d = 0.62). GM atrophy was significantly correlated with the mean GM dose with the SPM cl segmentation (r = − 0.4, p = 0.004), FSL full segmentation (r = − 0.4, p = 0.004) and FSL cl segmentation (r = -0.35, p = 0.012) but not with the SPM full segmentation (r = − 0.23, p = 0.1). Conclusions For accurate normal tissue volume measurements in brain tumour patients using SPM, abnormal tissue needs to be masked prior to segmentation, however, this is not necessary when using FSL.

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Section: Introductionmentioning

confidence: 84%

Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy

Gommlich

Raschke

Petr

et al. 2021

Magn Reson Mater Phy

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“…Neuroimaging plays an important role in uncovering cerebral morphological and functional abnormalities (25,26). Brain atrophy and GMV loss in cirrhotic patients are robust findings assessed by CT and MRI (2-6).…”

Section: Discussionmentioning

confidence: 99%

Increased serum malondialdehyde levels are associated with grey matter volume loss in patients with non-alcoholic cirrhosis

Zheng

Zhu

Feng

et al. 2019

Quant. Imaging Med. Surg

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Background: Grey matter volume (GMV) loss has been observed in patients with non-alcoholic cirrhosis, but the underlying mechanisms are unknown. Oxidative stress (OS) is a recognized feature and systemic phenomenon of cirrhosis. However, little is known about whether OS is associated with GMV loss in cirrhosis. This study aimed to assess the relationship between oxidative damage and GMV loss in patients with non-alcoholic cirrhosis. Methods: Thirty-four patients with non-alcoholic cirrhosis and 27 age-and sex-matched healthy controls were enrolled in this prospective study. All subjects underwent brain magnetic resonance imaging (MRI), and voxel-based morphometry (VBM) was performed to assess normalized global GMV. As an OS marker, serum malondialdehyde (MDA) levels were determined in all subjects. In the patient group, a correlation analysis was used to investigate the relationship between serum MDA levels and normalized global GMV. Results: Compared with healthy controls, cirrhotic patients displayed a significant decrease in normalized global GMV and a significant increase in serum MDA levels. In the patient group, serum MDA levels were negatively correlated with normalized global GMV adjusted for age, sex and Child-Pugh class. Conclusions: Increased serum MDA levels were associated with GMV loss in patients with non-alcoholic cirrhosis, suggesting that oxidative damage may be involved in GMV loss observed in cirrhotic patients.

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“…Cognitive impairment in patients with the bilateral hippocampal received RT is significantly worse than other brain regions, although the dose of radiation is the same [32].…”

Section: Factors Influencing Radiation-related Cognitive Impairmentmentioning

confidence: 94%

Research on the Mechanism of Radiation-Related Cognitive Impairment—A Review

Zuo¹,

Huang²

2019

JCT

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Radiotherapy (RT) remains a kind of front-line treatment for the control of tumor growth, especially for brain cancer. It is well known that cognitive impairment is mainly caused by cerebral RT, but the mechanisms underlying radiation-induced cognitive impairment remain unclear. There are different views on the cognitive dysfunction caused by RT in different studies. The recently research evidences about this topic are reviewed in present work. We found a few of factors including brain injury directly caused by radiation, cerebral tissue ischemia and necrosis caused by cerebrovascular injury, oxidative stress and brain injury mediated by inflammation, etc. which play a crucial role in the cognitive dysfunction caused by radiotherapy. These have all been widely recognized, and recently evidences have also shown that potential therapeutic interventions can effectively prevent cognitive impairment.

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Radiation-induced gray matter atrophy in patients with nasopharyngeal carcinoma after intensity modulated radiotherapy: a MRI magnetic resonance imaging voxel-based morphometry study

Cited by 28 publications

References 28 publications

Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy

Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy

Increased serum malondialdehyde levels are associated with grey matter volume loss in patients with non-alcoholic cirrhosis

Research on the Mechanism of Radiation-Related Cognitive Impairment—A Review

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