1990
DOI: 10.1007/bf01210553
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Radiation-induced cytotoxicity, DNA damage and DNA repair: Implications for cell survival theory

Abstract: The radiosensitivities and the kinetics for removal of radiation-induced DNA damage were compared for proliferative (P) and quiescent (Q) cells of the lines 66 and 67 derived from a mouse mammary adenocarcinoma. As determined from cell survival assays, the 66 and 67 Q cells were more radiosensitive than their 66 and 67 P counterparts. The rank order of their radiosensitivity was: 67 Q greater than 66 Q greater than or equal to 67 P greater than 66 P. Induction of radiation damage in the DNA of these cells, as … Show more

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Cited by 9 publications
(1 citation statement)
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“…Radiation injury of the central nervous system (CNS) has devastating and fatal clinical consequences and severely limits the dose that can be delivered in the radiotherapy of brain, head and neck, pulmonary and other tumors [19,28,30,64,65]. Hematopoetic system toxicity is a major limiting factor in the use of aggressive, combined modality therapy (chemotherapy + radiotherapy) in the treatment of malignant disease [14,22,40]. Permanent anemia and pancytopenia can be caused by the reduced capability for cellular proliferation due to the stem cells injury produced by radiation.…”
Section: Inflammation Induced By Radiationmentioning
confidence: 99%
“…Radiation injury of the central nervous system (CNS) has devastating and fatal clinical consequences and severely limits the dose that can be delivered in the radiotherapy of brain, head and neck, pulmonary and other tumors [19,28,30,64,65]. Hematopoetic system toxicity is a major limiting factor in the use of aggressive, combined modality therapy (chemotherapy + radiotherapy) in the treatment of malignant disease [14,22,40]. Permanent anemia and pancytopenia can be caused by the reduced capability for cellular proliferation due to the stem cells injury produced by radiation.…”
Section: Inflammation Induced By Radiationmentioning
confidence: 99%