Radiation-induced cancer after radiotherapy for non-Hodgkin's lymphoma of the head and neck: a retrospective study

Abstract

Background: survivors of non-Hodgkin's lymphoma (NHL) are well known to be at an increased risk of second malignancies. In this study, we evaluated the incidence and clinical features of head and neck cancer (HNC) occurring after radiotherapy (RT) for NHL.

Radiation-Induced Malignancies Making Radiotherapy a “Two-Edged Sword”: A Review of Literature

“…In 1989, a study by Cooper et al showed 110 second, independent, malignant tumors out of 928 patients with squamous cell carcinoma of head and neck [ 19 ]. Toda et al investigated 322 patients in a retrospective study who had received radiotherapy for early-stage non-Hodgkin’s lymphoma (NHL) of the head and neck and found four cases of RIM [ 20 ].…”

Radiation-Induced Malignant Peripheral Nerve Sheath Tumor of the Vagus Nerve Following Radiation Treatment of Cervical Paraganglioma

“…Latency in our case between radiation exposure and sarcoma development is just over 4 years, consistent with Cahan et al's original criteria but less than the median reported by others. 13 14 16 17 18 19 This may be attributable to the patient's relative young age and the possible presence of a genetic tumor predisposition syndrome. The final Cahan et al's criteria, that the induced neoplasm arises from tissue “normal” prior to treatment, are in this case speculative.…”

Nodal metastasis microRNA expression correlates with the primary tumour in MTC

“…Such an approach has also been suggested for the generic problem of carcinoma of unknown primary, and may also be applicable to unique scenarios involving the potential for dual pathology. For example, post oral cancer resection and neck dissection where external beam radiotherapy may increase the risk of head and neck malignancy generally; thus making the distinction between recurrence and new primary disease difficult …”