Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells

Luchette, Matthew; Korideck, Houari; Makrigiorgos, Mike; Tillement, Olivier; Berbeco, R.

doi:10.1016/j.nano.2014.06.004

Cited by 69 publications

(55 citation statements)

References 24 publications

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“…For 50 nm citrate-gold NP, ratio of surviving fractions at 4 Gy were 3.94 and 1.42 for 105 kVp and 6 MeV (Chithrani et al, 2010). For AGuIX NP, Luchette et al gave dose enhancements of 1.54 and 1.15 for 220 kVp and 6 MeV (Luchette et al, 2014). For Hf, the same trend was illustrated by Maggiorella (Maggiorella et al, 2012).…”

Section: Is There An Energy Dependency?mentioning

confidence: 80%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

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Section: Is There An Energy Dependency?mentioning

confidence: 80%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

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“…Nanoparticles such as gadolinium nanoparticles have the potential to improve radiotherapy 82,83 but also provide magnetic resonance imaging (MRI) contrast, which would resonate with recent IGRT developments towards MRI-guided radiotherapy 82,84,85 . The use of nanoparticles with image contrast capability could also facilitate non-invasive monitoring of the effect of radiotherapy and immunotherapy combinations on tumour progression, as shown in recent studies, with nanoparticles designed to allow tracking of cancer-specific T cells in vivo 86,87 .…”

Section: Overcoming Immunosuppressionmentioning

confidence: 99%

Using immunotherapy to boost the abscopal effect

et al. 2018

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More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression of metastatic cancer at distant sites that are not irradiated was described and called the abscopal effect (from ‘ab scopus’, that is, away from the target). The abscopal effect has been connected to mechanisms involving the immune system. However, the effect is rare because at the time of treatment, established immune-tolerance mechanisms may hamper the development of sufficiently robust abscopal responses. Today, the growing consensus is that combining radiotherapy with immunotherapy provides an opportunity to boost abscopal response rates, extending the use of radiotherapy to treatment of both local and metastatic disease. In this Opinion article, we review evidence for this growing consensus and highlight emerging limitations to boosting the abscopal effect using immunotherapy. This is followed by a perspective on current and potential cross-disciplinary approaches, including the use of smart materials to address these limitations.

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“…Interestingly, NPs were designed to serve as radiosensitization enhancers. [14][15][16] Heavy metal (with high-Z elements such as Au, Pt, Bi, Ta, Gd, and Lu 17,18 ) NPs as promising computed tomography (CT) contrast agents (CAs) could be used in radiosensitizing therapy because of their high X-ray photon capture cross-section and compton scattering effect. When X-rays interact with high-Z NPs, Auger electrons and photoelectrons are emitted, with diameters ranging from nanometers to several micrometers.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

Lou

Jiang

et al. 2017

IJN

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The inherent radioresistance and inaccuracy of localization of tumors weaken the clinical implementation effectiveness of radiotherapy. To overcome these limitations, hyaluronic acid-functionalized bismuth oxide nanoparticles (HA-Bi 2 O 3 NPs) were synthesized by one-pot hydrothermal method for target-specific computed tomography (CT) imaging and radiosensitization of tumor. After functionalization with hyaluronic acid, the Bi 2 O 3 NPs possessed favorable solubility in water and excellent biocompatibility and were uptaken specifically by cancer cells overexpressing CD44 receptors. The as-prepared HA-Bi 2 O 3 NPs exhibited high X-ray attenuation efficiency and ideal radiosensitivity via synergizing X-rays to induce cell apoptosis and arrest the cell cycle in a dose-dependent manner in vitro. Remarkably, these properties offered excellent performance in active-targeting CT imaging and enhancement of radiosensitivity for inhibition of tumor growth. These findings demonstrated that HA-Bi 2 O 3 NPs as theranostic agents exhibit great promise for CT imaging-guided radiotherapy in diagnosis and treatment of tumors.

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Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells

Cited by 69 publications

References 24 publications

Actual questions raised by nanoparticle radiosensitization

Actual questions raised by nanoparticle radiosensitization

Using immunotherapy to boost the abscopal effect

Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

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