Radiation-chemical transformations of coumarins in ethanolic solutions

Samovich, S. N.; Бринкевич, С. Д.; Edimecheva, Irina; Шадыро, О. И.

doi:10.1016/j.radphyschem.2014.03.015

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…Aqueous ethanol solutions are widely used in stud ies of radioprotectant, antioxidant, and other proper ties of biologically active substances (e.g., vitamins) and their substituted synthetic analogues [1][2][3][4][5]. The activity of these compounds in processes involving free radicals is assessed by measuring the radiation chem ical yield of a certain stable radiolytic product, usually generated by gamma radiation.…”

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confidence: 99%

Gamma-radiolysis of the ethanol-water binary system in the presence of oxygen

2015

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A study of the gamma radiolysis of the aerated ethanol-water system in a wide range of compo nent concentrations has shown that the main process occurring in this system is selective radiation induced oxidation of ethanol to acetaldehyde. The byproducts accumulating in the liquid phase are 2,3 butanediol and formaldehyde. The selectivity of the process increases with an increase in the alcohol content and decreases with an increase in the radiation dose. A theoretical radiolysis model created in this study is in good quantitative agreement with experimental data. Calculated product buildup curves exhibit breaking points characterized by an abrupt change in the radiation chemical yield. Their origin is due to the complete burn out of oxygen in the closed system or its insufficiently rapid transfer to the liquid in the two phase liquid/gas system.

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confidence: 99%

Gamma-radiolysis of the ethanol-water binary system in the presence of oxygen

2015

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“…[67] Fraxetin enables to add α-hydroxyethyl radicals to the double bond of pyrone ring to afford stable products with molecular masses over those of the original molecules. [100] Fraxetin was also reported to inhibit peroxidase-catalyzed tetramethylbenzidine in a noncompetitive manner with the inhibitory constant K i of 26 µM. [68] The EtOAc fraction containing a high amount of fraxetin acted as a promising antioxidative agent in DPPH, ABTS 45.77 µg/mL, and reducing power: IC 50 426.73 µg/mL).…”

Section: In Vitro 50 µMmentioning

confidence: 99%

“…[ 67 ] Fraxetin enables to add α‐hydroxyethyl radicals to the double bond of pyrone ring to afford stable products with molecular masses over those of the original molecules. [ 100 ] Fraxetin was also reported to inhibit peroxidase‐catalyzed tetramethylbenzidine in a noncompetitive manner with the inhibitory constant K i of 26 µM. [ 68 ]…”

Section: Pharmacologymentioning

confidence: 99%

Health benefits of fraxetin: From chemistry to medicine

Ha,

Son

2024

Archiv der Pharmazie

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Fraxetin is a bioactive molecule present in various natural plants, especially Cortex Fraxini. Evidenced outcomes in phytochemical and biological analyses for this agent are now available in the literature, but an insightful review is yet unknown. The goal of the current research is to offer a panoramic illustration of natural observation, biosynthesis, synthesis, pharmacology, and pharmacokinetics for fraxetin. Esculetin and ferulic acid acted as precursors in the enzymatic biosynthetic route, whereas fraxetin could be easily synthesized from simple phenols. A great deal of interest was obtained in using this molecule for pharmacological targets. Herein, its pharmacological value included anticancer, antioxidative, anti‐inflammatory, antidiabetic, antiobesity, and antimicrobial activities, as well as the protection of the liver, neurons, heart, bone, lung, kidney, and others. Anticancer activity may involve the inhibition of proliferation, invasion, and migration, together with apoptotic induction. Health benefits from this molecule were deduced from its ability to suppress cytokines and protect the immune syndrome. Various signaling pathways, such as Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3), phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt), nuclear factor kappa B (NF‐κB)/NLRP3, Akt/AMPK, have been proposed for in vitro and in vivo mechanisms of action. Fraxetin is highly distributed to rat plasma and several organs. However, more pharmacokinetic studies to improve its bioavailability are needed since its solubility in water is still limited.

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ROS-induced lipid transformations without oxygen participation

Шадыро

Lisovskaya

2019

Chemistry and Physics of Lipids

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Radiation-chemical transformations of coumarins in ethanolic solutions

Cited by 11 publications

References 40 publications

Gamma-radiolysis of the ethanol-water binary system in the presence of oxygen

Gamma-radiolysis of the ethanol-water binary system in the presence of oxygen

Health benefits of fraxetin: From chemistry to medicine

ROS-induced lipid transformations without oxygen participation

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