Radiation biology

Kiefer, Jürgen; Schenk‐Meuser, Karin; Kost, Michael

doi:10.1007/978-3-642-61099-8_6

Cited by 21 publications

(3 citation statements)

References 496 publications

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“…In addition to the individual effects of radiation and microgravity, there are also synergistic effects at the level of molecules and tissues. Therefore, the total effects constitute the aggregate of effects from radiation, microgravity, and synergy, and all the individual and synergistic bio-effects require in-depth investigation (Horneck, 1992(Horneck, , 1999Horneck et al, 1996Horneck et al, , 1997Kiefer et al, 1996;Moore & Cogoli, 1996;Pross et al, 1994Pross et al, , 2000Reitz et al, 1992).…”

Section: Bio-effects Of Ionization Radiationmentioning

confidence: 99%

Radiation Measured for Chinese Satellite SJ‐10 Space Mission

et al. 2018

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s Space biological effects are mainly a result of space radiation particles with high linear energy transfer (LET); therefore, accurate measurement of high LET space radiation is vital. The radiation in low Earth orbits is composed mainly of high‐energy galactic cosmic rays (GCRs), solar energetic particles, particles of radiation belts, the South Atlantic Anomaly, and the albedo neutrons and protons scattered from the Earth's atmosphere. CR‐39 plastic nuclear track detectors sensitive to high LET are the best passive detectors to measure space radiation. The LET method that employs CR‐39 can measure all the radiation LET spectra and quantities. CR‐39 detectors can also record the incident directions and coordinates of GCR heavy ions that pass through both CR‐39 and biosamples, and the impact parameter, the distance between the particle's incident point and the seed's spore, can then be determined. The radiation characteristics and impact parameter of GCR heavy ions are especially beneficial for in‐depth research regarding space radiation biological effects. The payload returnable satellite SJ‐10 provided an excellent opportunity to investigate space radiation biological effects with CR‐39 detectors. The space bio‐effects experiment was successfully conducted on board the SJ‐10 satellite. This paper introduces space radiation in low Earth orbits and the LET method in radiation‐related research and presents the results of nuclear tracks and biosamples hitting distributions of GCR heavy ions, the radiation LET spectra, and the quantities measured for the SJ‐10 space mission. The SJ‐10 bio‐experiment indicated that radiation may produce significant bio‐effects.

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Section: Bio-effects Of Ionization Radiationmentioning

confidence: 99%

Radiation Measured for Chinese Satellite SJ‐10 Space Mission

et al. 2018

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“…Tables 5 and 6 list some health issues caused by the space and space flight environment, such as radiation diseases, bone demineralisation and the space adaptation syndrome. Since the radiation exposure likely to be experienced during a Mars mission is not fully documented (Kiefer et al, 1996), a permanent dose rate monitoring and a radiation shelter, available during solar particle events, are mandatory on both, the transfer vehicle as well as the Mars habitat. For a more detailed discussion of the radiation health issues, the reader is referred to the HUMEX study (Horneck et al, 2003a,b).…”

Section: Health Issues Caused By the Space And Spaceflight Environmentmentioning

confidence: 99%

General human health issues for Moon and Mars missions: Results from the HUMEX study

Horneck

Comet

2006

Advances in Space Research

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“…Kozubek et al [4] proposed a theoretical explanation of mutation induction by heavy ion beams in above bacteria from track structure models, and they concluded that the`Kiefer and Straaten model' and thè Kudryashov et al model' were in good agreement with the experimental results. Kiefer et al [5] also summarized the e¡ects of heavy ions on living organisms in space and on earth.…”

Section: Introductionmentioning

confidence: 99%

Lethality of high linear energy transfer cosmic radiation to Escherichia coli DNA repair-deficient mutants during the 'SL-J/FMPT' space experiment

Harada¹

1998

FEMS Microbiology Letters

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We investigated the lethal and mutagenic effects of high linear energy transfer cosmic radiation on 11 strains of Escherichia coli, including DNA repair-deficient mutants, using the Radiation Monitoring Container and Dosimeter in the space shuttlè Endeavour' as part of the`SL-J/FMPT' space experiment, the`Fuwatto '92' project. After the return to earth of the shuttle, we evaluated survival and mutations of samples in space and matched controls. The surviving fractions were determined by means of colony count on broth agar plates, and the mutation frequencies were estimated by appearance of arg revertants on minimal agar plates. The average of the total equivalent dose rate during this space flight was 0.202 mSv/day as measured by the plastic radiation detectors and the thermoluminescent dosimeters in the Radiation Monitoring Container and Dosimeter. The combined action of DNA polymerase and 3PC5P exonuclease activities was found to make the greatest contribution to the repair of cosmic radiation-induced DNA damage, 5PC3P exonuclease and recombination repair enzyme activities made a moderate contribution, whereas UV endonuclease activity was not involved in this DNA repair process. z

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Radiation biology

Cited by 21 publications

References 496 publications

Radiation Measured for Chinese Satellite SJ‐10 Space Mission

Radiation Measured for Chinese Satellite SJ‐10 Space Mission

General human health issues for Moon and Mars missions: Results from the HUMEX study

Lethality of high linear energy transfer cosmic radiation to Escherichia coli DNA repair-deficient mutants during the 'SL-J/FMPT' space experiment

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