Radiation and Other Physical Agents

Lombardini, Eric; Pacheco-Thompson, Michelle E.; Melanson, Mark A

doi:10.1016/b978-0-12-415759-0.00044-3

Cited by 5 publications

(4 citation statements)

References 112 publications

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“…fluorescens monocultures ( Table ) show that in the case of 280 nm, the k value is 0.36 ± 0.033, which is similar to the values obtained in a study by Rattanakul and Oguma (2018) for another strain of Pseudomonas (i.e., Pseudomonas aeruginosa; k = 0.42), in which it was also treated at 280 nm. Lower k values were observed at 365 nm (0.002 ± 0.0003), likely because the action spectra of UVA are less effective per physical unit (mJ/cm 2 ) compared to UVC and UVB . No previous studies have treated P.…”

Section: Resultsmentioning

confidence: 92%

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Comparison of Legionella pneumophila and Pseudomonas fluorescens Quantification Methods for Assessing UV LED Disinfection

Lara de Larrea,

MacIsaac,

Rauch

et al. 2023

ACS EST Water

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This study assesses the efficacy of ultraviolet light-emitting diodes (UV LEDs) for deactivating Legionella pneumophila (pure culture) and Pseudomonas fluorescens (pure culture and biofilms) on relevant drinking water distribution system surfaces (cast iron and stainless steel). UV LED treatment at 280 nm demonstrated superior performance compared to that at 365 nm, achieving a 4.8 log reduction value (LRV) for P. fluorescens pure cultures and, for biofilms, 4.02 LRV for stainless steel and 2.96 LRV for cast iron at 280 nm. Conversely, the results were less effective at 365 nm, with suspected photolytic reactions on cast iron. Quantification of L. pneumophila yielded varying results: 4 LRV using standard plate counts, 1.8 LRV with Legiolert, and 1 LRV with quantitative polymerase chain reaction at 280 nm, while the results were less than 1.5 LRV at 365 nm. This study provides insights into managing opportunistic pathogens and biofilms, emphasizing the need for improved quantification tools to better assess treatment efficacy.

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Section: Resultsmentioning

confidence: 92%

“…Lower k values were observed at 365 nm (0.002 ± 0.0003), likely because the action spectra of UVA are less effective per physical unit (mJ/cm 2 ) compared to UVC and UVB. 51 No previous studies have treated P. fluorescens at 365 nm.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Legionella pneumophila and Pseudomonas fluorescens Quantification Methods for Assessing UV LED Disinfection

Lara de Larrea,

MacIsaac,

Rauch

et al. 2023

ACS EST Water

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“…Despite the fact that SGs have a relatively slow turnover rate, compared with fast-cycling tissues such as intestine, they respond to radiation injury as would a tissue with a high turnover rate [18,19]. Indeed, soft tissues that are highly vascularised often show acute effects due to IR [20], despite use of a fractionated approach [21]. Cumulative exposure to IR causes extensive destruction of the saliva-producing acini [22] (Figure 2C) and reduced salivary flow rate [17].…”

Section: Head and Neck Cancer Radiotherapymentioning

confidence: 99%

Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration

Rocchi

Emmerson

2020

Trends in Molecular Medicine

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“…(Fajardo et al 2002). Vascular damage induced by ionizing radiation is considered to be related to degenerative/ apoptotic endothelial cells leading to increased vascular permeability and acute inflammatory response (Lombardini et al 2013).…”

Section: Arterial Changes With Radiation-based Treatmentmentioning

confidence: 99%

Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

et al. 2018

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Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and nature from age-related polyarteritis nodosa in rats or monkeys, and Beagle pain syndrome in dogs. In minipigs, it can be present in a single small- or medium-sized artery of an organ or a few organs and is most commonly recorded in the cardiac and extracardiac blood vessels, vagina, oviduct, rectum, epididymis, spinal cord, pancreas, urinary bladder, kidneys, and stomach. The etiology is unknown although it has been considered in minipigs as well as in rats, dogs, and monkeys to be possibly immune mediated. This background change is important with respect to its nature and distribution in the minipig in order to distinguish it from drug-induced vascular changes, which might occur in similar locations and have similar morphologic features. This review summarizes the morphology, incidence, and predilection sites of arteritis as a spontaneously occurring background change and as a drug-induced vasculopathy in the minipig, and also describes the main aspects to consider when evaluating vascular changes in Göttingen minipig toxicity studies and their human relevance.

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Radiation and Other Physical Agents

Cited by 5 publications

References 112 publications

Comparison of Legionella pneumophila and Pseudomonas fluorescens Quantification Methods for Assessing UV LED Disinfection

Comparison of Legionella pneumophila and Pseudomonas fluorescens Quantification Methods for Assessing UV LED Disinfection

Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration

Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

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